Abstract: The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TR? mutation.

Abstract: The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TR? mutation.

Abstract: A system for analyzing a coating test on a test surface with a portable electronic device includes a hood that is at least partially open at a bottom side thereof and fixable with the portable electronic device at an opposing top side thereof. At least one lamp is fixed with an inside surface of the hood and is adapted to project light towards the open bottom side thereof. A software application is resident on a memory of the portable electronic device that directs a processor of the portable electronic device to at least a) capture an image of an original color input area (CIA) of the test surface as a reference, b) capture an image of an area of interest (AOI) of the test surface, and c) compare the AOI to the CIA to determine a percentage of the coating that has been removed in the test.

Abstract: In a dialysis system wherein blood is removed from a patient's vascular system and passed through a dialyzer system comprising an inlet arterial line, a dialyzer, and an outlet venous line, the blood being fed via the inlet arterial line to the dialyzer and returned to the patient via the outlet venous line, a material having a physical property differing from that of blood is injected at a point in the venous return line. The fluid in the dialysis system upstream from the injection point is monitored for the presence of the different physical property whereby direct recirculation from the venous return line to the arterial intake line is detected.