Abstract: This invention provides compounds of formula I that are useful in the treatment or inhibition of LXR mediated diseases.

Abstract: Driveline lash and clunk are controlled in a powertrain system having multiple torque-generative and torque control devices using a multivariable feedback control approach to provide active driveline damping. Control parameters used by a state estimator are different, depending on whether the driveline lash is taken up or is currently slack. When the estimated driveline axle torque is not substantially zero, the nominal parameters for transmission mode or gear are used in the state estimator. When the estimated axle torque is substantially zero, the parameters are switched to neutral parameters, the lash estimator indicates neutral lash state, and angle of lash is tracked until it accumulates an expected amount of lash in the driveline. During a lash transition time, active damping controls the driveline component speeds so that the effect of lash take-up is minimized. After lash take-up occurs, desired axle torque is used by the system.

Abstract: A hybrid powertrain system includes a transmission device operative to transfer power between an input member, a torque machine and an output member, the output member coupled to a driveline coupled to a wheel to transfer tractive torque therebetween. A method for controlling the hybrid powertrain system includes monitoring an operator torque request, determining an operating range state of the transmission device, determining a net output torque to the output member based upon the operator torque request, determining a lash state of the driveline, and determining a command for transferring output torque to the output member based upon the operating range state of the transmission device, the net output torque, and the lash state of the driveline.

Abstract: A multivariable feedback control approach to actively dampen magnitude of jerks in a powertrain system using multiple torque-control devices is offered. To manage jerks, a desired axle torque is restricted when a torque reversal occurs. When the vehicle operator or the system executes a command that requires change in direction of torque, the desired axle torque is limited to a low level until the lash estimate has changed accordingly. During this transition time, active damping controls driveline component speeds so that the effect of lash take-up is minimized. After lash take-up occurs, the desired axle torque proceeds without restriction. The invention includes determining a desired axle torque, an output speed of the transmission, and an output speed of a driven wheel of the driveline. One of the devices is controlled based upon a time-rate change in the desired axle torque.

Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R, R?, A, A?, X, Y, and Y are as defined in the specification, or a pharmaceutically acceptable salt thereof.

Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R, R′, A, A′, X, Y, and Y are as defined in the specification, or a pharmaceutically acceptable salt thereof.

Abstract: This invention is directed to oxoazaheterocycyl compounds which inhibit Factor Xa, to oxoazaheterocycyl compounds which inhibit both Factor Xa and Factor IIa, to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these compounds, to a method of directly inhibiting Factor Xa and to a method of simultaneously directly inhibiting Factor Xa and Factor IIa..

Abstract: This invention provides estrogen receptor modulators of formula I, having the structure 1

Abstract: A propulsion system designed for hybrid vehicles utilizing a first torque path from a coupled motor generator system and internal combustion engine through and automatically shifted manual transmission having a secondary torque path from a secondary torque source to the wheels. The system incorporates the high-efficiency of a manual transmission with the smoothness of the most advanced automatic transmissions by utilizing a second torque path to maintain driver requested torque during shifts and braking requests.

Abstract: A propulsion system for use in a hybrid vehicle, wherein a first propulsion system provides a driving force to a first pair of wheels and a second propulsion system provides a driving force to a second pair of wheels. A system controller actuates the propulsion systems determines the necessary commands to be provided to the first and second propulsion systems so as to provide the vehicle with the most efficient driving and/or stopping force.

Abstract: A propulsion system designed for hybrid vehicle's utilizing a first torque path from a coupled motor generator system and internal combustion engine through and automatically shifted manual transmission having a secondary torque path from a secondary torque source to the wheels. The system incorporates the high-efficiency of a manual transmission with the smoothness of the most advanced automatic transmissions by utilizing a second torque path to maintain driver requested torque during shifts. The system is also capable of performing shifts without opening the clutch by utilizing active synchronization of the input shaft RPM combined with the force control of the shifting actuator. This results in fast and smooth shifts that disengage and reengage without unpleasant torque pulsations.

Abstract: A vehicular visual safety device having a pair of substantially parallel mirrors secured within the interior of the vehicle in fixed relationship with the driver. The rear-most mirror is positioned so as to capture an image lateral and forward of the device's position below the level of the front view window and front portion of the vehicle on the side of the vehicle opposite to the driver's position. The forward-most mirror is laterally offset towards the driver relative to the rear-most mirror and is positioned so as to capture an image of the rear-most mirror. Specifically, the vehicular visual safety device includes a mirror assembly having a planar reflecting forward-most mirror and a convex object rear-most mirror each having an upper edge that lies in respective vertical planes that are substantially parallel with each other. A frame assembly is provided to adjustably secure the mirror pair within the vehicle.

Abstract: This invention relates to a class of novel amino bi- and tri-carbocyclic alkane compounds having bis-aryl substitution which exhibit squalene synthase inhibition properties. The bi- and tri-carbocyclic alkane ring contains an amino group and the ring is further linked or bridged to two mono- and/or bicyclic rings. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.

Abstract: This invention relates to polycyclic compounds containing two mono- and/or bicyclic rings and a basic tertiary amino group capable of forming an ammonium ion at biological pH and which reduces levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.

Abstract: This invention relates to a class of novel amino bi- and tri-carbocyclic alkane compounds having bis-aryl substitution which exhibit squalene synthase inhibition properties. The bi- and tri-carbocyclic alkane ring contains an amino group and the ring is further linked or bridged to two mono- and/or bicyclic rings. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.

Abstract: This invention relates to polycyclic compounds containing two mono- and/or bicyclic rings and a basic tertiary amino group capable of forming an ammonium ion at biological pH and which reduces levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.The compounds of this invention are described by the formula ##STR1## where Ar I is phenylene or naphthylene, Ar II is phenyl or naphthyl and A is 1-azabicyclo[2.2.2]octan-3-yl.

Abstract: An electro-mechanical controller for a transmission selector in a synchronized countershaft transmission, includes a selector shaft which is driven linearly and rotatably by a power actuator mechanism to provide gear selection within the countershaft transmission. A selector rod is coupled with the selector shaft through a connection that provides compliance and damping therebetween. The selector rod has a finger mechanism which is selectively connectible with synchronizers in the transmission to provide the desired gear selection. The selector shaft and selector rod are controlled in both linear and rotatable motion by translating mechanisms in the actuator mechanism to thereby control the selector rod in the gear selection positions and in a neutral condition.

Abstract: An electro-mechanical controller for a transmission selector in a synchronized countershaft transmission, includes a selector shaft which is driven linearly and rotatably by a power actuator mechanism to provide gear selection within the countershaft transmission. A selector rod is coupled with the selector shaft through a connection that provides compliance and damping therebetween. The selector rod has a finger mechanism which is selectively connectible with synchronizers in the transmission to provide the desired gear selection. The selector shaft and selector rod are controlled in both linear and rotatable motion by translating mechanisms in the actuator mechanism to thereby control the selector rod in the gear selection positions and in a neutral condition.

Abstract: Disclosed are novel benzothiopyranyl derivatives as 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula: ##STR1## their corresponding dihydroxy acids, and pharmaceutically acceptable salts thereof.