Patents by Inventor Robert L. Schmitt
Robert L. Schmitt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220175822Abstract: Embodiments are directed towards methods of inducing caspase activity. The methods include contacting a cell with a treatment compound represented by the following Formula (I), where the treatment compound is a random copolymer, R1 is selected from hydrogen and a hydroxyl group, R2 is selected from hydrogen and a hydroxyl group, R1 is different than R2, and a sum of x and y is from 4 to 20,000.Type: ApplicationFiled: February 27, 2020Publication date: June 9, 2022Applicant: Dow Global Technologies LLCInventors: Caroline Woelfle-Gupta, Andrew Scott, Matthew LeBaron, Daniel Wilson, Susan L. Jordan, Robert L. Schmitt, Raja Settivari
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Publication number: 20220125830Abstract: Embodiments are directed towards methods of inducing caspase activity. The methods include contacting a cell with a treatment compound formed by alkoxylation of an initiator using an oxide.Type: ApplicationFiled: February 26, 2020Publication date: April 28, 2022Applicant: Dow Global Technologies LLCInventors: Caroline Woelfle-Gupta, Andrew Scott, Matthew LeBaron, Daniel Wilson, Susan L. Jordan, Robert L. Schmitt, Raja Settivari
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Publication number: 20220054534Abstract: Embodiments are directed towards methods of inducing caspase activity. The methods include contacting a cell with a treatment compound represented by the following Formula (I): where R1 is selected from hydrogen or an alkyl group having from 1 to about 16 carbon atoms; R2 is selected from a hydroxyl group, a tosylate group, an alkoxy group of the formula OR3 where R3 is selected from an alkyl group having from 1 to about 16 carbon atoms, or an ester group of the formula OCOR4, where R4 is an alkyl group having from 1 to about 16 carbon atoms, and n is from 4 to 46,000, with the proviso that when R1 is hydrogen and R2 is a hydroxy group the treatment compound has a number average molecular weight from 10,100 to 2,000,0000 g/mol.Type: ApplicationFiled: February 26, 2020Publication date: February 24, 2022Applicant: Dow Global Technologies LLCInventors: Caroline Woelfle-Gupta, Andrew Scott, Matthew LeBaron, Daniel Wilson, Susan L. Jordan, Robert L. Schmitt, Raja Settivari
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Patent number: 11000594Abstract: A liquid composition which comprises an organic liquid diluent and at least one non-ionic cellulose ether having a viscosity of up to 2.33 mPa·s, measured as a 2 wt.-% solution in water at 20° C., is stable over an extended time period. The liquid composition is useful for preparing a solid dispersion comprising at least one active ingredient in at least one cellulose ether by spray-drying. Alternatively a solid dispersion can be produced by blending and extruding at least one active ingredient, at least one cellulose ether having a viscosity of up to 2.33 mPa·s and optionally one or more adjuvants.Type: GrantFiled: March 19, 2019Date of Patent: May 11, 2021Assignee: Dow Global Technologies LLCInventors: Meinolf Brackhagen, Nicholas S. Grasman, Mark J. Hall, Steven J. Guillaudeu, Robert L. Schmitt, Matthias Knarr
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Publication number: 20190209693Abstract: A liquid composition which comprises an organic liquid diluent and at least one non-ionic cellulose ether having a viscosity of up to 2.33 mPa·s, measured as a 2 wt.-% solution in water at 20° C., is stable over an extended time period. The liquid composition is useful for preparing a solid dispersion comprising at least one active ingredient in at least one cellulose ether by spray-drying. Alternatively a solid dispersion can be produced by blending and extruding at least one active ingredient, at least one cellulose ether having a viscosity of up to 2.33 mPa»s and optionally one or more adjuvants.Type: ApplicationFiled: March 19, 2019Publication date: July 11, 2019Inventors: Meinolf Brackhagen, Nicholas S. Grasman, Mark J. Hall, Steven J. Guillaudeu, Robert L. Schmitt, Matthias Knarr
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Patent number: 10272156Abstract: A liquid composition which comprises an organic liquid diluent and at least one non-ionic cellulose ether having a viscosity of up to 2.33 mPa·s, measured as a 2 wt.-% solution in water at 20° C., is stable over an extended time period. The liquid composition is useful for preparing a solid dispersion comprising at least one active ingredient in at least one cellulose ether by spray-drying. Alternatively a solid dispersion can be produced by blending and extruding at least one active ingredient, at least one cellulose ether having a viscosity of up to 2.33 mPa·s and optionally one or more adjuvants.Type: GrantFiled: October 13, 2016Date of Patent: April 30, 2019Assignee: DOW GLOBAL TECHNOLOGIES LLCInventors: Meinolf Brackhagen, Nicholas S. Grasman, Mark J. Hall, Steven J. Guillaudeu, Robert L. Schmitt, Matthias Knarr
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Publication number: 20180362737Abstract: A composition comprising a) an esterified cellulose ether comprising aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, R being a divalent hydrocarbon group, wherein I) the degree of neutralization of the groups —C(O)—R—COOH is not more than 0.4 and II) the total degree of ester substitution is from 0.03 to 0.70, and b) a cellulose ether having a viscosity of from 1.2 to 200 mPa s, measured as a 2 weight-% aqueous solution at 20° C., gels at increased temperature and displays reduced syneresis when further increasing the temperature of the gel.Type: ApplicationFiled: November 15, 2016Publication date: December 20, 2018Applicant: Dow Global Technologies LLCInventors: Oliver PETERMANN, Robert L. SCHMITT
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Patent number: 9890221Abstract: Esterified cellulose ethers comprising groups of formula —C(O)—CHR?—CHR?—COOA, wherein, R? and R? are hydrogen or (—S)m(—R1)n-R2, wherein R1 is a hydrocarbon group having 1 to 4 carbon atoms, R2 is an optionally substituted 5- or 6-membered cyclic group, m and n each independently are 0 or 1, and A is hydrogen or a cation, with the proviso that in each group CHR?—CHR? one of R? and R? is hydrogen and the other one is (—S)m(—R1)n-R2, are useful as excipients for maintaining the concentration of poorly water-soluble drugs in aqueous liquids at supersaturation levels.Type: GrantFiled: May 7, 2014Date of Patent: February 13, 2018Assignees: Dow Global Technologies LLC, University of MinnesotaInventors: Ligeng Yin, Marc A. Hillmyer, Steven J. Guillaudeu, Robert L. Schmitt
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Patent number: 9782356Abstract: A polymeric capsule shell of high quality is prepared from an aqueous composition which comprises (A) at least one esterified cellulose ether comprising aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, R being a divalent aliphatic or aromatic hydrocarbon group, wherein at least a part of the groups —C(O)—R—COOH are neutralized with an ammonium salt of carbonic acid, formic acid or acetic acid, and (B) from 0 to 7 weight percent of a non-polymeric plasticizer, based on the weight of the esterified cellulose ether, wherein the weight of said at least one esterified cellulose ether is at least 80 percent of the total polymer weight in the aqueous composition.Type: GrantFiled: April 28, 2015Date of Patent: October 10, 2017Assignee: Dow Global Technologies LLCInventors: Jin Zhao, Roland Adden, Brian Koblinski, Robert L. Schmitt
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Publication number: 20170181976Abstract: A polymeric capsule shell of high quality is prepared from an aqueous composition which comprises (A) at least one esterified cellulose ether comprising aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, R being a divalent aliphatic or aromatic hydrocarbon group, wherein at least a part of the groups —C(O)—R—COOH are neutralized with an ammonium salt of carbonic acid, formic acid or acetic acid, and (B) from 0 to 7 weight percent of a non-polymeric plasticizer, based on the weight of the esterified cellulose ether, wherein the weight of said at least one esterified cellulose ether is at least 80 percent of the total polymer weight in the aqueous composition.Type: ApplicationFiled: April 28, 2015Publication date: June 29, 2017Applicant: Dow Global Technologies LLCInventors: Jin Zhao, Roland Adden, Brian Koblinski, Robert L. Schmitt
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Publication number: 20170028069Abstract: A liquid composition which comprises an organic liquid diluent and at least one non-ionic cellulose ether having a viscosity of up to 2.33 mPa·s, measured as a 2 wt.-% solution in water at 20° C., is stable over an extended time period. The liquid composition is useful for preparing a solid dispersion comprising at least one active ingredient in at least one cellulose ether by spray-drying. Alternatively a solid dispersion can be produced by blending and extruding at least one active ingredient, at least one cellulose ether having a viscosity of up to 2.33 mPa·s and optionally one or more adjuvants.Type: ApplicationFiled: October 13, 2016Publication date: February 2, 2017Inventors: Meinolf Brackhagen, Nicholas S. Grasman, Mark J. Hall, Steven J. Guillaudeu, Robert L. Schmitt, Matthias Knarr
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Patent number: 9486532Abstract: Esterified cellulose ethers which comprise (i) aliphatic monovalent acyl groups or (ii) groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, or (iii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, which have a viscosity of up to 2.33 mPa·s, measured as a 2.0 wt % solution of the esterified cellulose ether in 0.43 wt % aqueous NaOH at 20° C., and which have a viscosity of up to 13 mPao·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C. are useful for preparing solid dispersions comprising drugs.Type: GrantFiled: February 28, 2014Date of Patent: November 8, 2016Inventors: Meinolf Brackhagen, Steven J. Guillaudeu, Nicholas S. Grasman, Oliver Petermann, Robert L. Schmitt, Matthias Sprehe
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Publication number: 20160289344Abstract: Esterified cellulose ethers comprising groups of formula —C(O)—CHR?—CHR?—COOA, wherein, R? and R? are hydrogen or (—S)m (—R1)n-R2, wherein R1 is a hydrocarbon group having 1 to 4 carbon atoms, R2 is an optionally substituted 5- or 6-membered cyclic group, m and n each independently are 0 or 1, and A is hydrogen or a cation, with the proviso that in each group CHR?—CHR? one of R? and R? is hydrogen and the other one is (—S)m (—R1)n-R?, are useful as excipients for maintaining the concentration of poorly water-soluble drugs in aqueous liquids at supersaturation levels.Type: ApplicationFiled: May 7, 2014Publication date: October 6, 2016Inventors: Ligeng Yin, Marc A. Hillmyer, Steven J. Guillaudeu, Robert L. Schmitt
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Patent number: 9320799Abstract: An esterified cellulose ether comprises (i) aliphatic monovalent acyl groups or (ii) groups of the formula —C(O)—R—COOA wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation or (iii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein the cellulose ether has anhydroglucose units joined by 1-4 linkages and has methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl as substituents such that the esterified cellulose ether has an MS (hydroxyalkyl) of 0.05 to 1.00, and hydroxyl groups of anhydroglucose units are substituted with methyl groups such that [s23/s26?0.2*MS(hydroxyalkyl)] is 0.Type: GrantFiled: October 24, 2012Date of Patent: April 26, 2016Inventors: Robert L. Schmitt, Robert L. Sammler, Meinolf Brackhagen, Oliver Petermann, Roland Adden, Nicholas S. Grasman, Steven J. Guillaudeu
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Publication number: 20150374831Abstract: Esterified cellulose ethers which comprise (i) aliphatic monovalent acyl groups or (ii) groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, or (iii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, which have a viscosity of up to 2.33 mPa·s, measured as a 2.0 wt % solution of the esterified cellulose ether in 0.43 wt % aqueous NaOH at 20° C., and which have a viscosity of up to 13 mPao·s, measured as a 10 wt % solution of the esterified cellulose ether in acetone at 20° C. are useful for preparing solid dispersions comprising drugs.Type: ApplicationFiled: February 28, 2014Publication date: December 31, 2015Applicant: DOW GLOBAL TECHNOLOGIES LLCInventors: Meinolf Brackhagen, Steven J. Guillaudeu, Nicholas S. Grasman, Oliver Petermann, Robert L. Schmitt, Matthias Sprehe
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Publication number: 20150320869Abstract: A liquid composition which comprises an organic liquid diluent and at least one hydroxypropyl methylcellulose having 28 to 30 weight percent of methoxyl groups, 7 to 12 weight percent of hydroxypropoxyl groups and a sum of methoxyl groups and hydroxypropoxyl groups of from 38.5 to 42 weight percent is stable over an extended time period. The liquid composition is useful for preparing a solid dispersion comprising at least one active ingredient in at least one hydroxypropyl methylcellulose by spray-drying. Alternatively a solid dispersion can be produced by blending and extruding at least one active ingredient, at least one hydroxypropyl methylcellulose described above and optionally one or more adjuvants.Type: ApplicationFiled: July 21, 2015Publication date: November 12, 2015Inventors: Meinolf Brackhagen, Robert L. Schmitt, Matthias Knarr
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Publication number: 20150218197Abstract: Two or more esters of a cellulose ether, each having the same ether and ester substituents but different weight average molecular weights are prepared in a process which comprises the steps of esterifying a cellulose ether with (i) an aliphatic monocarboxylic acid anhydride or (ii) a dicarboxylic acid anhydride or (iii) a combination of an aliphatic monocarboxylic acid anhydride and a dicarboxylic acid anhydride in the presence of an aliphatic carboxylic acid as a reaction diluent in two or more separate reactions, wherein in each reaction a different molar ratio [aliphatic carboxylic acid/anhydroglucose units of cellulose ether] is used to produce esters of the cellulose ether of different weight average molecular weights.Type: ApplicationFiled: August 15, 2013Publication date: August 6, 2015Inventors: Oliver Petermann, Matthias Sprehe, Robert L. Schmitt, Andrew C. Arthur, Warren K. Miller, David K. Lyon
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Publication number: 20150209436Abstract: A liquid composition which comprises an organic liquid diluent and at least one non-ionic cellulose ether having a viscosity of up to 2.33 mPa·s, measured as a 2 wt.-% solution in water at 20° C., is stable over an extended time period. The liquid composition is useful for preparing a solid dispersion comprising at least one active ingredient in at least one cellulose ether by spray-drying. Alternatively a solid dispersion can be produced by blending and extruding at least one active ingredient, at least one cellulose ether having a viscosity of up to 2.33 mPa·s and optionally one or more adjuvants.Type: ApplicationFiled: July 12, 2013Publication date: July 30, 2015Inventors: Meinolf Brackhagen, Nicholas S. Grasman, Mark J. Hall, Steven J. Guillaudeu, Robert L. Schmitt, Matthias Knarr
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Patent number: 9084417Abstract: A composition including an ethylene blocking agent complex formed from the product of an ethylene blocking agent and a host, and at least one water-soluble polymer, wherein the ethylene blocking agent complex and the at least one water-soluble polymer are intermingled is disclosed.Type: GrantFiled: December 9, 2013Date of Patent: July 21, 2015Assignee: Dow AgroSciences LLCInventors: Gretchen Baier, Mark D. Newsham, Irina V. Graf, Robert L. Schmitt, Lamy J. Chopin, III, Jacquelyn A. deGroot, Jeffrey J. Wooster, Tarlochan Singh Dhadialla
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Publication number: 20150072858Abstract: The present disclosure is directed to cellulose ether compositions for film-forming coating applications. A coating composition is provided which contains an aqueous solution of either a very low viscosity cellulose ether or a low-hydroxypropyl cellulose ether, the coating composition having low color. The low viscosity of the cellulose ether component enables the coating composition to contain a high concentration of cellulose ether. Provision of these high concentration cellulose ether coating solutions improves production efficiency by reducing the time required to coat a substrate.Type: ApplicationFiled: November 13, 2014Publication date: March 12, 2015Inventors: True L. Rogers, Debora L. Holbrook, Karen A. Coppens, Robert L. Schmitt