Abstract: A creatinine clearance monitoring and fluid level management system for use in the treatment of patients. The system establishes and adjusts the dosing of intravenous fluids based upon periodic creatinine clearance calculations based upon a system specified frequency. Warning or alert messages or signals are produced if creatinine clearance levels indicate the need for the administration of additional fluids based upon a creatinine clearance result below an established normal threshold. Furthermore, the system generates a warning to trigger a more serious intervention in the event a patient's creatinine clearance rate falls below a lower established threshold or the system determines that an inordinate amount of fluids have been administered without the anticipated response. The creatinine clearance monitoring and fluid level management system is particularly useful for patients in a hospital or in-patient environment, and particularly those post-operative patients or those in intensive care.