Abstract: Apelin receptor modulators can improve physical performance, slow progression of age-related frailty, and can reduce age-related muscle weakness in human patients. This disclosure provides methods for treating muscle conditions using a particular class of apelin receptor modulators (e.g., agonists). The muscle condition can be an age-related muscle condition. Also provided is a method for maintaining and/or increasing muscle mass, muscle function, and/or muscle strength in an elderly subject by administration of the apelin receptor modulator. In some embodiments, the apelin receptor modulator (e.g., agonist) is BGE-105, or a pharmaceutically acceptable salt thereof.

Abstract: Disclosed is (1) a method of manufacturing a binder product, (2) an apparatus for use in operations for manufacturing binder products, (3) an improved binder which utilizes a rigid and arcuate spine board, and (4) an improved binder product with lid boards which are of a size in the range of industry standard sizes, but which are capable of fully enclosing tabbed document archiving office products.