Abstract: A composition, comprising: a plurality of mechanically-activated microcapsules; a mechanically-activated microcapsule defining a shell and an exterior surface; and the mechanically-activated microcapsule comprising one or more adhesion groups disposed Non the exterior surface of the mechanically-activated microcapsule, the one or more adhesion groups being configured to effect a covalent interaction, a non-covalent interaction, or both between the one or more adhesion groups and a matrix material, the covalent interaction, the non-covalent interaction, or both adhering the mechanically-activated microcapsule to the matrix material. Also provided are related methods and related articles.

Abstract: A door assembly for selectively interlocking opposing doors each pivotably mounted at a hinge side thereof to a door frame so as to both open and close in the same direction includes a door handle assembly mounted to one door at a latch side thereof opposite the hinge side and carrying a first plurality of magnets, and another door handle assembly mounted to the other door at a latch side thereof opposite the hinge side and carrying a second plurality of magnets. The door handle assemblies are arranged relative to each other with the first and second pluralities of magnets aligned such each aligned pair of the first and second pluralities of magnets have opposite magnetic polarities, and the aligned first and second pluralities of magnets magnetically couple to each other as the door handle assemblies are brought into contact with each other.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: Feedstocks are provided for use in the additive manufacturing of three-dimensional objects via extrusion-based techniques, such as Fused Filament Fabrication (“FFF”) or Fused Deposition Modeling (“FDM”). Generally, the feedstocks may be in the form of substantially continuous filaments and/or in the form of rods of specified length, with diameters in excess of 3.5 mm.

Abstract: The invention relates to methods for the treatment or prevention of anaemia of inflammation comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of an inhibitor of the Ca2+-activated potassium channel (Gardos channel), an inhibitor of interaction of one or more chemokines with Duffy antigen receptor for chemokines (DARC), and a compound that inhibits activation of adhesion molecules expressed on erythrocytes.

Abstract: A light guide has an elongated body that includes an entrance face at which light is admitted into the light guide and an exit face at which the light emanates from the light guide. The light guide has an inboard side wall and an outboard side wall extending between the entrance face and the exit face. The entrance face, the exit face, the inboard side wall and the outboard side wall enclose a medium containing a colorant by which the medium meets a color criterion while minimizing light absorption at a wavelength of the light.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the compounds of Formula (I) for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: The present invention pertains to a lighting device for an automobile comprising a housing, a plurality of light sources arranged inside the housing and an optical element arranged in front of the plurality of light source. The optical element includes an input surface, an output surface and a transparent portion that is disposed between the input surface and the output surface. In addition, the optical element includes at least one part of the transparent portion having a blocking portion that is created using a laser treatment. The blocking portion is configured to block at least a part of the plurality of light beams from passing through the optical element.

Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: A monitoring system that is configured to monitor a property is disclosed. The monitoring system includes a sensor that is configured to generate sensor data that reflects an environmental condition of the property and an electrical monitoring device coupled to an electrical cord that provides power to an electrical device located at the property. The electrical monitoring device is configured to generate electrical data that reflects electricity that flows through the electrical cord. The monitoring system includes a monitor control unit that is configured to: receive, from the sensor, the sensor data; receive, from the electrical monitoring device, the electrical data; and analyze the sensor data and the electrical data. The monitor control unit is configured to: based on analyzing the sensor data and the electrical data, determine a status of the electrical device; and based on the status of the electrical device, perform a monitoring system action.

Abstract: A circuit for direct current (DC) offset estimation comprises a quantile value circuit and a signal processor. The quantile value circuit determines a plurality of quantile values of an input signal and includes a plurality of quantile filters. Each quantile filter includes a comparator, a level shifter, a monotonic transfer function component, and a latched integrator. The comparator compares the input signal and a quantile value. The level shifter shifts the output of the comparator. The monotonic transfer function component determines the magnitude of the shifted signal and provide a transfer function signal. The latched integrator suppresses transient characteristics of the transfer function signal and provide the quantile value. The signal processor is configured to calculate a weighted average of the quantile values to yield a DC offset estimate.

Abstract: In an example, a method is performed by a computing system that is one of a group of computing systems involved in facilitating a manufacturing of an aircraft. The method comprises generating a plurality of manufacturing task work statements (MTWSs), each MTWS being associated with a task involved in the manufacturing and comprising smart contract data and computer code. The method also comprises receiving system state information indicating (i) a schedule according to which the aircraft is to be manufactured, (ii) resources available for use in executing the MTWSs, and (iii) one or more aircraft certification requirements with which the tasks involved in the manufacturing of the aircraft are to comply. The method also comprises executing the MTWSs based on the system state information and storing, in a blockchain-based distributed ledger accessible by the group of computing systems, an end state result of the execution of each MTWS.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: A semantic similarity fingerprint is generated for an image by inferring a plurality of SKUs each at an associated first weight based upon analysis of the image using the machine learning models. The associated first weights for each of the classifications based upon each machine learning model is the semantic similarity fingerprint. The semantic similarity fingerprint may be compared to previously generated semantic similarity fingerprints. If a match is found with a semantic similarity fingerprint that has previously been identified as a particular.

Abstract: Embodiments of the present invention relate to mechanically-activated microcapsules (MAMCs) for controlled drug-delivery, wherein the MAMCs release one or more active ingredients in response to mechanical stimuli in a subject's body. The MAMCs provide a platform for stimulating biological regeneration, biological repair, modifying disease, and/or controlling disease in mechanically-loaded musculoskeletal tissues.

Abstract: Semiconductor packages and package assemblies having active dies and external die mounts on a silicon wafer, and methods of fabricating such semiconductor packages and package assemblies, are described. In an example, a semiconductor package assembly includes a semiconductor package having an active die attached to a silicon wafer by a first solder bump. A second solder bump is on the silicon wafer laterally outward from the active die to provide a mount for an external die. An epoxy layer may surround the active die and cover the silicon wafer. A hole may extend through the epoxy layer above the second solder bump to expose the second solder bump through the hole. Accordingly, an external memory die can be connected directly to the second solder bump on the silicon wafer through the hole.

Abstract: Systems, methods, and techniques for detecting the recording activity of a sensor are described. A monitoring system includes a sensor that is configured to generate sensor data, as well as a failsafe circuit that is configured to monitor an electronic signal of the sensor and determine that the sensor is recording. The system can further include a control unit that receives indication from the failsafe circuit that the sensor is recording and, based on determining that the control unit did not request the sensor to record or that the control unit is not aware that the sensor is recording, the system outputs a signal, e.g. to an indicator light, indicating that the sensor is recording.

Abstract: A circuit for direct current (DC) offset estimation comprises a quantile value circuit and a signal processor. The quantile value circuit determines a plurality of quantile values of an input signal and includes a plurality of quantile filters. Each quantile filter includes a comparator, a level shifter, a monotonic transfer function component, and a latched integrator. The comparator compares the input signal and a quantile value. The level shifter shifts the output of the comparator. The monotonic transfer function component determines the magnitude of the shifted signal and provide a transfer function signal. The latched integrator suppresses transient characteristics of the transfer function signal and provide the quantile value. The signal processor is configured to calculate a weighted average of the quantile values to yield a DC offset estimate.

Abstract: A pet feeder tray having an elevated platform. The platform having multiple apertures for removable receiving bowls. The pet feeder tray having four legs at corners for elevating the platform to the desired height. Bowls adapted to receive the feed of a pet can be removably received within the apertures.