Patents by Inventor Robert Lloyd Binder
Robert Lloyd Binder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11633452Abstract: A method of treating vaginal dryness by administering a vaginal care composition, which includes an effective amount of a vaginal care agent, to vaginal tissue of a user experiencing vaginal dryness. The vaginal care agent may be selected to specifically treat symptoms of vaginal dryness exhibited by the introitus and/or labia, based on the transcriptomic data of skin cells obtained therefrom. In some instances, the vaginal care composition may be applied to introitus and/or labia with a suitable implement configured for such use.Type: GrantFiled: October 27, 2020Date of Patent: April 25, 2023Assignee: THE PROCTER & GAMBLE COMPANYInventors: Travis Kyle Hodgdon, Leo Timothy Laughlin, II, Samantha Chen-Yee Wang, Robert Lloyd Binder
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Publication number: 20210038632Abstract: A method of treating vaginal atrophy is provided. The method comprises administering a vaginal care composition to vaginal tissue of a user experiencing a symptom of vaginal atrophy. The vaginal care composition may include an effective amount of a vaginal care agent selected to specifically treat symptoms of vaginal atrophy exhibited by the introitus and/or labia, based on the transcriptomic data of skin cells obtained therefrom. In some instances, the vaginal care composition may be applied to introitus and/or labia with a suitable implement configured for such use.Type: ApplicationFiled: October 27, 2020Publication date: February 11, 2021Inventors: Travis Kyle HODGDON, Leo Timothy LAUGHLIN, II, Samantha Chen-Yee WANG, Robert Lloyd BINDER
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Publication number: 20210038679Abstract: A method of treating vaginal dryness by administering a vaginal care composition, which includes an effective amount of a vaginal care agent, to vaginal tissue of a user experiencing vaginal dryness. The vaginal care agent may be selected to specifically treat symptoms of vaginal dryness exhibited by the introitus and/or labia, based on the transcriptomic data of skin cells obtained therefrom. In some instances, the vaginal care composition may be applied to introitus and/or labia with a suitable implement configured for such use.Type: ApplicationFiled: October 27, 2020Publication date: February 11, 2021Inventors: Travis Kyle HODGDON, Leo Timothy LAUGHLIN, II, Samantha Chen-Yee WANG, Robert Lloyd BINDER
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Patent number: 10563258Abstract: A method for making a skin care composition by identifying connections between cosmetic agents and genes associated with one or more skin aging conditions. The method includes accessing a plurality of instances and at least one skin aging gene expression signature, comparing the at least one skin aging gene expression signature to the plurality of the instances, assigning a connectivity score to each instance based on the comparison and incorporating the cosmetic agent into a skin care composition when the connectivity score of the instance associated with the cosmetic agent has a negative correlation.Type: GrantFiled: June 25, 2015Date of Patent: February 18, 2020Assignee: The Procter & Gamble CompanyInventors: Robert Lloyd Binder, Robert Scott Youngquist, Jun Xu, Kenton Duane Juhlin, Rosemarie Osborne, Scott Michael Hartman
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Patent number: 10468120Abstract: A method of generating a hyperpigmentation condition gene expression signature for use in identifying connections between perturbagens and genes associated with a skin pigmentation condition. The method includes providing a gene expression profile for a reference sample of human skin cells not affected with a pigmentation condition; generating a gene expression profile for a sample of human skin cells from a subject exhibiting the hyperpigmentation condition; comparing the expression profiles to determine a gene expression signature that includes a set of differentially expressed genes; assigning an identifier to each gene constituting the gene expression signature and ordering the identifiers according to the direction of differential expression to create one or more gene expression signature lists; and storing the one or more gene expression signature lists on at least one computer readable medium.Type: GrantFiled: March 27, 2013Date of Patent: November 5, 2019Assignee: The Procter & Gamble CompanyInventors: Tomohiro Hakozaki, Wenzhu Zhao, Robert Lloyd Binder, Jun Xu
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Patent number: 10418127Abstract: A method of formulating a skin-lightening composition by identifying actives with a data architecture and incorporating the actives into a skin care composition. The data architecture can be used to identify connections between perturbagens and genes associated with skin tone. A gene expression profile for a control human cell is compared to the gene expression profile a cell exposed to perturbagen to identify the genes which are differentially expressed. The differentially expressed genes are analyzed and arranged into an ordered list of identifiers, which along with other instances create a data architecture.Type: GrantFiled: March 27, 2013Date of Patent: September 17, 2019Assignee: The Procter & Gamble CompanyInventors: Tomohiro Hakozaki, Wenzhu Zhao, Robert Lloyd Binder, Jun Xu
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Patent number: 10282514Abstract: A method of constructing a data architecture for use in identifying connections between perturbagens and genes associated with skin tone. The method includes providing a gene expression profile for a control cell, generating a gene expression profile for a cell exposed to a perturbagen, identifying genes differentially expressed in response to the perturbagen, creating an ordered list of identifiers, storing the ordered list as an instance on a computer readable medium, and constructing a data architecture of stored instances.Type: GrantFiled: March 27, 2013Date of Patent: May 7, 2019Assignee: The Procter & Gamble CompanyInventors: Tomohiro Hakozaki, Wenzhu Zhao, Robert Lloyd Binder, Jun Xu
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Patent number: 10072293Abstract: Methods and systems for determining functional relationships between a skin-active agent and a skin condition of interest, and methods and systems for identifying cosmetic agents effective for treatment of dandruff, as well as the use of agents identified by such methods and systems for the preparation of cosmetic compositions, personal care products, or both are provided. Methods for developing in vitro models of skin disease and models for specific skin diseases are also provided.Type: GrantFiled: April 2, 2012Date of Patent: September 11, 2018Assignee: The Procter and Gamble CompanyInventors: Kevin John Mills, Robert Lloyd Binder, Robert Scott Youngquist, Jun Xu, Ping Hu, Makio Tamura
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Patent number: 10036741Abstract: Methods and systems for constructing a gene expression signature representative of a number of biological conditions, systems and methods for determining functional relationships between a skin-active agent and skin conditions of interest, and methods and systems for identifying skin-active agents with broad spectrum activity are provided.Type: GrantFiled: August 14, 2013Date of Patent: July 31, 2018Assignee: The Procter & Gamble CompanyInventors: Kevin John Mills, Jun Xu, Robert Lloyd Binder, Robert Scott Youngquist, Deborah Ruth Finlay, Charles Carson Bascom
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Patent number: 9920357Abstract: Provided are methods and systems for determining functional relationships between a cosmetic agent and a hair biology condition of interest. Also provided are methods and systems for identifying cosmetic agents that affect a hair biology condition, as well as the use of agents identified by such methods and systems for the preparation of cosmetic compositions, personal care products, or both.Type: GrantFiled: June 6, 2013Date of Patent: March 20, 2018Assignee: The Procter & Gamble CompanyInventors: Robert Scott Youngquist, Jun Xu, Robert Lloyd Binder, Ping Hu, Teresa Dicolandrea, Thomas Larry Dawson, Brian Wilson Howard
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Publication number: 20170343534Abstract: Methods and systems for constructing a gene expression signature representative of a number of biological conditions, systems and methods for determining functional relationships between a skin-active agent and skin conditions of interest, and methods and systems for identifying skin-active agents with broad spectrum activity are provided.Type: ApplicationFiled: August 14, 2013Publication date: November 30, 2017Applicant: The Procter & Gamble CompanyInventors: Kevin John MILLS, Jun XU, Robert Lloyd BINDER, Robert Scott YOUNGQUIST, Deborah Ruth FINLAY, Charles Carson BASCOM
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Patent number: 9434993Abstract: A system for identifying connections between a cosmetic agent and at least one gene associated with a skin aging condition. The system includes a computer readable medium having stored thereon a plurality of instances and a skin aging gene expression signature. Each instance comprises an ordered list of identifiers representing a plurality of differentially expressed genes generated as a result of contact between the cosmetic agent and a human fibroblast cell or a human keratinocyte cell. The computing device includes computer-readable instructions for accessing the plurality of instances and the skin aging gene expression signature stored on the computer readable medium, comparing each of the instances to the skin aging gene expression signature, and assigning a connectivity score to each of the instances based on the comparison.Type: GrantFiled: June 25, 2015Date of Patent: September 6, 2016Assignee: The Procter & Gamble CompanyInventors: Robert Lloyd Binder, Robert Scott Youngquist, Jun Xu, Kenton Duane Juhlin, Rosemarie Osborne, Scott Michael Hartman
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Publication number: 20150322527Abstract: Gene panels, microarrays and biomarker panels relating to genes and gene products associated with age-related oxidative damage to skin, and transcriptional profiling-based methods for identification and evaluation of cosmetic agents for prevention, reversal, or reduction of oxidative damage to skin. Cosmetic agents and compositions comprising the cosmetic agents, capable of inducing nrf2-mediated activation of the antioxidant response element to increase expression of Phase 2 enzymes, methods for restoring optimal redox status to skin employing the agents, and methods for identifying and evaluating cosmetic agents acting via the nrf2-mediated mechanism.Type: ApplicationFiled: July 16, 2015Publication date: November 12, 2015Inventors: Deborah Ruth FINLAY, Robert Lloyd BINDER, Michael Keith ROBINSON, Rosemarie OSBORNE
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Publication number: 20150292017Abstract: A system for identifying connections between a cosmetic agent and at least one gene associated with a skin aging condition. The system includes a computer readable medium having stored thereon a plurality of instances and a skin aging gene expression signature. Each instance comprises an ordered list of identifiers representing a plurality of differentially expressed genes generated as a result of contact between the cosmetic agent and a human fibroblast cell or a human keratinocyte cell. The computing device includes computer-readable instructions for accessing the plurality of instances and the skin aging gene expression signature stored on the computer readable medium, comparing each of the instances to the skin aging gene expression signature, and assigning a connectivity score to each of the instances based on the comparison.Type: ApplicationFiled: June 25, 2015Publication date: October 15, 2015Inventors: Robert Lloyd Binder, Robert Scott Youngquist, Jun XU, Kenton Duane JUHLIN, Rosemarie OSBORNE, Scott Michael HARTMAN
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Publication number: 20150292018Abstract: A method for making a skin care composition by identifying connections between cosmetic agents and genes associated with one or more skin aging conditions. The method includes accessing a plurality of instances and at least one skin aging gene expression signature, comparing the at least one skin aging gene expression signature to the plurality of the instances, assigning a connectivity score to each instance based on the comparison and incorporating the cosmetic agent into a skin care composition when the connectivity score of the instance associated with the cosmetic agent has a negative correlation.Type: ApplicationFiled: June 25, 2015Publication date: October 15, 2015Inventors: Robert Lloyd BINDER, Robert Scott YOUNGQUIST, Jun XU, Kenton Duane JUHLIN, Rosemarie OSBORNE, Scott Michael HARTMAN
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Patent number: 8986664Abstract: The invention provides a method for improving hair biology, e.g., hair growth. The method comprises administering to a subject a monoamine oxidase inhibitor and a vasodilator, a zinc salt of a carboxylic acid, a xanthine compound, pyrithione or a salt thereof, saponin, tritapene, crataegolic acid, celastrol, asiatic acid, an inhibitor of 5-alpha-reductase, 1,4-methyl-4-azasteroid, an androgen receptor antagonist, azelaic acid or a derivate thereof, cyclosporin, triiodothyronine, diazoxide, retinoic acid, a prostaglandin analog, aminexil, carnitine tartrate, apigenin, procapil, or adenosine, in an amount effective to achieve a desired effect. The invention further provides a method of reducing or delaying the appearance of an age-related skin imperfection. The method comprises administering to the subject a composition comprising an MAO inhibitor. A kit for improving hair growth also is provided.Type: GrantFiled: October 13, 2011Date of Patent: March 24, 2015Assignee: The Procter & Gamble CompanyInventors: Teresa DiColandrea, Robert Scott Youngquist, Sancai Xie, Robert Lloyd Binder, Gary Richard Fuentes, Deborah Lade
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Publication number: 20130331342Abstract: Provided are methods and systems for determining functional relationships between a cosmetic agent and a hair biology condition of interest. Also provided are methods and systems for identifying cosmetic agents that affect a hair biology condition, as well as the use of agents identified by such methods and systems for the preparation of cosmetic compositions, personal care products, or both.Type: ApplicationFiled: June 6, 2013Publication date: December 12, 2013Inventors: Robert Scott Youngquist, Jun Xu, Robert Lloyd Binder, Ping Hu, Teresa Dicolandrea, Thomas Larry Dawson, Brian Wilson Howard
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Publication number: 20130261024Abstract: A system for identifying connections between perturbagens and genes associated with a skin hyperpigmentation condition. The system includes a computer readable medium having a plurality of instances stored thereon, and a skin hyperpigmentation-relevant gene expression signature. Each instance includes an instance list of rank-ordered identifiers of differentially expressed genes, and the hyperpigmentation-relevant gene expression signature includes a gene expression signature list of identifiers representing differentially expressed genes associated with a hyperpigmentation condition or differentially expressed genes associated with a benchmark skin-lightening agent.Type: ApplicationFiled: March 27, 2013Publication date: October 3, 2013Applicant: The Procter & Gamble CompanyInventors: Tomohiro HAKOZAKI, Wenzhu ZHAO, Robert Lloyd BINDER, Jun XU
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Publication number: 20130259816Abstract: A method of formulating a skin-lightening composition by identifying actives with a data architecture and incorporating the actives into a skin care composition. The data architecture can be used to identify connections between perturbagens and genes associated with skin tone. A gene expression profile for a control human cell is compared to the gene expression profile a cell exposed to perturbagen to identify the genes which are differentially expressed. The differentially expressed genes are analyzed and arranged into an ordered list of identifiers, which along with other instances create a data architecture.Type: ApplicationFiled: March 27, 2013Publication date: October 3, 2013Applicant: The Procter & Gamble CompanyInventors: Tomohiro HAKOZAKI, Wenzhu ZHAO, Robert Lloyd BINDER, Jun XU
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Publication number: 20130261006Abstract: A method of generating a hyperpigmentation condition gene expression signature for use in identifying connections between perturbagens and genes associated with a skin pigmentation condition. The method includes providing a gene expression profile for a reference sample of human skin cells not affected with a pigmentation condition; generating a gene expression profile for a sample of human skin cells from a subject exhibiting the hyperpigmentation condition; comparing the expression profiles to determine a gene expression signature that includes a set of differentially expressed genes; assigning an identifier to each gene constituting the gene expression signature and ordering the identifiers according to the direction of differential expression to create one or more gene expression signature lists; and storing the one or more gene expression signature lists on at least one computer readable medium.Type: ApplicationFiled: March 27, 2013Publication date: October 3, 2013Applicant: The Procter & Gamble CompanyInventors: Tomohiro HAKOZAKI, Wenzhu ZHAO, Robert Lloyd BINDER, Jun XU