Abstract: This disclosure describes, in part, techniques for providing captions with audio content. For instance, an electronic device may receive first data representing audio content and second data representing captions that are available for the audio content. The electronic device may then select portions of the captions for display while outputting the audio content. In some instances, the electronic device selects the portions using timestamps represented by the second data. For instance, the electronic device may select a portion of the captions such that the portion of the captions begins at a first pause within the audio content and/or ends at a second pause within the audio content. In some instances, the electronic device may also display graphical elements that indicate the current location within the captions.

Abstract: The present invention provides Ligand-Drug Conjugates comprising a PEG Unit in a parallel orientation to the Drug Unit. The invention provides inter alia. Ligand-Drug Conjugates (LDCs), methods of preparing and using them, and intermediates thereof. The Ligand-Drug Conjugates are stable in circulation, yet capable of inflicting cell death on targeted cells or inhibiting proliferation of targeted cells once its drug cargo is released in the vicinity or within targeted cells. In principle embodiments, an LDC of the present invention is represented by the structure of Formula I.

Abstract: Described herein is a panel construction, a process for preparing the same and a method of using the same as an automotive part.

Abstract: Systems and methods for resiliency testing are disclosed. In one embodiment, a method for building rules based on application execution information may include (1) an agent deploying to a software application; (2) the agent receiving an application behavior rule; (3) the agent monitoring execution of the software application; (4) the agent detecting a breach of the application behavior rule during software application; (5) the agent retrieving application execution information from the software application; and (6) the agent outputting the application execution information.

Abstract: The present invention provides Ligand-Drug Conjugates, Drug-Linkers, Linkers, and Ligand-Linker Conjugates comprising a self-stabilizing linker assembly component.

Abstract: Hydrophilic Linkers, Drug-Linker compounds, Drug-Ligand Conjugate compounds and Ligand-Linkers and methods of making and using the same are provided.

Abstract: The present invention provides Ligand-Drug Conjugates comprising a PEG Unit in a parallel orientation to the Drug Unit. The invention provides inter alia, Ligand-Drug Conjugates (LDCs), methods of preparing and using them, and intermediates thereof. The Ligand-Drug Conjugates are stable in circulation, yet capable of inflicting cell death on targeted cells or inhibiting proliferation of targeted cells once its drug cargo is released in the vicinity or within targeted cells. In principle embodiments, an LDC of the present invention is represented by the structure of Formula I.

Abstract: A child car seat is disclosed. The car seat has a seat form for accommodating a child. A belt for retaining a child is disposed within the child car seat. A first buckle is operable between a first open position and a second other fastened position, for when fastened fastening the belt to retain a child and for when open facilitating installation and removal of a child from the child car seat. The child car seat also has an integrated interface port for removably retaining a first electronic circuit having communication circuitry for communicating with an automobile. The interface port has electrical conductors for electrically coupling with the electrical circuitry within the first electronic circuit.

Abstract: An exterior elevated assembly with a walking surface is described which has features for facilitating inspection of the interior support frame of the assembly. The assembly includes a support frame for the walking surface, which defines an interior space and a soffit covering an underside of the support frame. The soffit provided with an opening. A vent panel is provided for covering the opening and a vent panel retention mechanism is provided for reversibly holding the vent panel in place over the opening. Methods and kits for installing a vent panel in a soffit of an exterior elevated assembly with a walking surface are also described.

Abstract: Hydrophilic Linkers, Drug-Linker compounds, Drug-Ligand Conjugate compounds and Ligand-Linkers and methods of making and using the same are provided.

Abstract: The present disclosure relates to a pultrusion process for preparing a reinforced thermoset polyurethane composite, and specifically relates to a pultrusion process for simultaneous optimization of fiber sizing continuously along with the pultrusion process without any interruption by contacting the fibers with a sizing composition.

Abstract: A laminate nanomold includes a layer of perfluoropolyether defining a cavity that has a predetermined shape and a support layer coupled with the layer of perfluoropolyether. The laminate can also include a tie-layer coupling the layer of perfluoropolyether with the support layer. The tie-layer can also include a photocurable component and a thermal curable component. The cavity can have a broadest dimension of less than 500 nanometers.

Abstract: Compounds and compositions are disclosed in which a NAMPT Drug Unit is conjugated to a targeting Ligand Unit through quaternization by a Linker Unit from which a NAMPT inhibitor compound or derivative thereof is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as those of cancer or an autoimmune disease, using the compounds and compositions of the invention are also disclosed.

Abstract: A soffit vent for providing access to an interior space above a soffit via an opening in the soffit. The soffit vent includes a panel for covering the opening; and a panel retention mechanism for reversibly holding the panel in place over the opening. A method for installing the soffit vent is also included, as well as a kit for installing and/or retrofitting a soffit vent on a soffit.

Abstract: The invention is based in part on the observation that a CHO cell oxidizing enzyme, particularly QSOX1, can survive a seemingly rigorous antibody purification process to reduce subsequent conjugation efficiency of the antibody to a drug. Whether the oxidizing enzyme survives the purification procedure depends on which purification techniques are employed which can vary from one antibody to another. With knowledge that contamination with a CHO cell oxidizing enzyme is a potential problem for subsequent conjugation, a suitable purification scheme can be devised for any antibody that eliminates or at least reduces CHO oxidizing enzyme(s) to an acceptable level.

Abstract: The invention is based in part on the observation that a CHO cell oxidizing enzyme, particularly QSOX1, can survive a seemingly rigorous antibody purification process to reduce subsequent conjugation efficiency of the antibody to a drug. Whether the oxidizing enzyme survives the purification procedure depends on which purification techniques are employed which can vary from one antibody to another. With knowledge that contamination with a CHO cell oxidizing enzyme is a potential problem for subsequent conjugation, a suitable purification scheme can be devised for any antibody that eliminates or at least reduces CHO oxidizing enzyme(s) to an acceptable level.

Abstract: Methods and apparatus for characterizing composite materials for manufacturing quality assurance (QA), periodic inspection during the useful life, or for forensic analysis/material testing. System are provided that relate eddy-current sensor responses to the fiber layup of a composite structure, the presence of impact damage on a composite structure with or without a metal liner, volumetric stress within the composite, fiber tow density, and other NDE inspection requirements. Also provided are systems that determine electromagnetic material properties and material dimensions of composite materials from capacitive sensor inspection measurements. These properties are related to the presence of buried defects in non-conductive composite materials, moisture ingress, aging of the material due to service or environmental/thermal exposure, or changes in manufacturing quality.

Abstract: Systems and methods for gamified engineering education are disclosed. Embodiments are directed to an interactive learning exercise designed to allow participants to interact with a complex system, make observations, apply various performance engineering tactics and tools, and optimize the complex system based upon findings. At a high level, the system is a simulated casino floor with multiple pre-defined components, stations, roles, and tasks. The objective of the game is to settle as many player wagers as possible in a set amount of time by “tuning” various aspects of the casino operations. Aspects of the system—the components, stations, roles, tasks, etc.—have analogs in engineering problems. The knowledge gained, including the understanding of how different elements and aspects work with each other, may be applied by the participants to solve future engineering problems.

Abstract: A workstation with at least one computer processor receives a plurality of testing tools for testing a program. The workstation receives from a server a testing dashboard. The testing dashboard includes core code that retrieves an external configuration file for one of the plurality of tools and injects the external configuration file into the one of the plurality of tools at runtime. The testing dashboard also includes a testing script that specifies an order of execution of the plurality of tools. The workstation executes the core code to retrieve the external configuration file for the one of the plurality of tools. The workstation executes the testing script to execute the plurality of tools. The workstation presents the results of the execution of the testing script.

Abstract: A workstation with at least one computer processor receives a plurality of testing tools for testing a program. The workstation receives from a server a testing dashboard. The testing dashboard includes core code that retrieves an external configuration file for one of the plurality of tools and injects the external configuration file into the one of the plurality of tools at runtime. The testing dashboard also includes a testing script that specifies an order of execution of the plurality of tools. The workstation executes the core code to retrieve the external configuration file for the one of the plurality of tools. The workstation executes the testing script to execute the plurality of tools. The workstation presents the results of the execution of the testing script.