Patents by Inventor Robert M. Blake

Robert M. Blake has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240148858
    Abstract: There are provided herein, inter alia, complexes, compositions and methods for a vaccine for COVID-19. The cell-penetrating complexes provided herein may include a nucleic acid non-covalently bound to a cationic amphipathic polymer, the cationic amphipathic polymer including a pH-sensitive immolation domain. The cell-penetrating complexes provided herein are, inter alia, useful in vaccines, wherein the vaccine includes a ribonucleic acid including a sequence encoding a viral protein, a nucleic acid adjuvant and a cationic amphipathic polymer provided herein including embodiments thereof.
    Type: Application
    Filed: July 26, 2021
    Publication date: May 9, 2024
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ronald Levy, Ole Audun Werner Haabeth, Adrienne Sallets, Timothy R. Blake, Paul Wender, Robert M. Waymouth, Debra Czerwinski, Idit Sagiv-Barfi, Julian Johannes Lohmeyer
  • Patent number: 11931416
    Abstract: There are provided herein, inter alia, cationic amphipathic polymers, complexes, and compositions comprising same, and methods for their use including for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acids, into a cell. The complexes, compositions and methods may facilitate delivery and targeted release of the therapeutic, diagnostic and imaging agents to particular cell types and tissues.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: March 19, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Tim R. Blake, Paul Wender, Robert M. Waymouth, Ronald Levy, Ole Audun Werner Haabeth, Rebecca McClellan, Adrienne Sallets
  • Patent number: 5533036
    Abstract: In a memory system comprising a plurality of memory units each of which possesses unit-level error correction capabilities and each of which are tied to a system level error correction function, memory reliability is enhanced by providing means for disabling the unit-level error correction capability, for example, in response to the occurrence of an uncorrectable error in one of the memory units. This counter-intuitive approach which disables an error correction function nonetheless enhances overall memory system reliability since it enables the employment of the complement/recomplement algorithm which depends upon the presence of reproducible errors for proper operation. Thus, chip level error correction systems, which are increasingly desirable at high packaging densities, are employed in a way which does not interfere with system level error correction methods.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 2, 1996
    Assignee: International Business Machines Corporation
    Inventors: Robert M. Blake, Douglas C. Bossen, Chin-Long Chen, John A. Fifield, Howard L. Kalter
  • Patent number: 5297091
    Abstract: In a memory system, which includes a dynamic random access memory (DRAM) that has to be precharged before the contents thereof can be selectively read out into a static register, there is provided means for reading the memory contents of the memory cells of a part or the whole of a row of memory cells of the DRAM into the static register while concurrently precharging the DRAM for a subsequent read-out command. This reduces the overall cycle time of the memory array since read-out of the static register can occur during precharge.
    Type: Grant
    Filed: October 31, 1991
    Date of Patent: March 22, 1994
    Assignee: International Business Machines Corporation
    Inventors: Robert M. Blake, William P. Hovis, David J. Perlman
  • Patent number: 5228046
    Abstract: In a memory system comprising a plurality of memory units each of which possesses unit-level error correction capabilities and each of which are tied to a system level error correction function, memory reliability is enhanced by providing a mechanism for disabling the unit-level error correction capability, for example, in response to the occurrence of an uncorrectable error in one of the memory units. This counter-intuitive approach which disables an error correction function nonetheless enhances overall memory system reliability since it enables the employment of the complement/recomplement algorithm which depends upon the presence of reproducible errors for proper operation. Thus, chip level error correction systems, which are increasingly desirable at high packaging densities, are employed in a way which does not interfere with system level error correction methods.
    Type: Grant
    Filed: November 12, 1991
    Date of Patent: July 13, 1993
    Assignee: International Business Machines
    Inventors: Robert M. Blake, Douglas C. Bossen, Chin-Long Chen, John A. Fifield, Howard L. Kalter
  • Patent number: 5058115
    Abstract: In a memory system comprising a plurality of memory units each of which possesses unit-level error correction capabilities and each of which are tied to a system level error correction function, memory reliability is enhanced by providing means for fixing the output of one of the memory units at a fixed value in response to the occurrence of an uncorrectable error in one of the memory units. This counter-intuitive approach to the generation of forced hard errors nonetheless enhances overall memory system reliability since it enables the employment of the complement/recomplement algorithm which depends upon the presence of reproducible errors for proper operation. Thus, clip level error correction systems, which are increasingly desirable at high packaging densities, are employed in a way which does not interfere with system level error correction methods.
    Type: Grant
    Filed: March 10, 1989
    Date of Patent: October 15, 1991
    Assignee: International Business Machines Corp.
    Inventors: Robert M. Blake, Douglas C. Bossen, Chin-Long Chen, John A. Fifield, Howard L. Kalter, Tin-Chee Lo