Abstract: Disclosed are compounds and methods for treating tauopathy.

Abstract: Methods and apparatus to control movement of a component are disclosed herein. An example apparatus includes a housing defining a bore and a piston disposed inside the bore. The piston is to be coupled to a movable component disposed outside of the bore. The example apparatus further includes a fluid flowline in fluid communication with a first chamber of the bore and a second chamber of the bore. The first chamber is on a first side of the piston, and the second chamber on a second side of the piston. The example apparatus also includes a valve to control fluid flow through the fluid flowline. The valve is to be in a first state to enable the piston to dampen movement of the component, and the valve is to be in a second state to enable the piston to hold the component substantially stationary.

Abstract: A transmission device, comprising an offset gearbox assembly coupling rotatable input and output shafts extending in respective input and output axial directions. An output gear is mounted in the offset gearbox assembly and is rotatable in a drive direction about an output gear axis to rotate the output shaft coupled therewith. An idler gear coupled to the output gear is rotatable about an idler gear axis in association with the output gear. An input gear assembly is coupled to the idler gear, is rotatable about an input gear axis in association with the idler gear, and is coupled to the input shaft such that rotation of the input shaft causes rotation of the output gear in the drive direction. The input gear assembly has the input shaft coupled therewith such that the input axial direction is nonparallel to the output axial direction. An associated method is also provided.

Abstract: A transmission device, comprising an offset gearbox assembly coupling rotatable input and output shafts extending in respective input and output axial directions. An output gear is mounted in the offset gearbox assembly and is rotatable in a drive direction about an output gear axis to rotate the output shaft coupled therewith. An idler gear coupled to the output gear is rotatable about an idler gear axis in association with the output gear. An input gear assembly is coupled to the idler gear, is rotatable about an input gear axis in association with the idler gear, and is coupled to the input shaft such that rotation of the input shaft causes rotation of the output gear in the drive direction. The input gear assembly has the input shaft coupled therewith such that the input axial direction is nonparallel to the output axial direction. An associated method is also provided.

Abstract: Provided are half system torque brakes, aircraft utilizing these brakes, and methods of installing these brakes. A half system torque brake includes an input cam assembly slidably disposed on a compression shaft between first and second output cam assemblies. The second output cam assembly is disposed between the input cam assembly and a rotor-stator assembly. When a torque differential between the input cam assembly and either one of the output cam assemblies exceeds its threshold, the same rotor-stator assembly is engaged and prevents further rotation of any cam assembly. Specifically, when the torque differential corresponding to the first output cam assembly exceeds its threshold, this assembly advances away from the input cam assembly and pulls the compression shaft in the same direction, which in turn engages the rotor-stator assembly by advancing the pressure plate to the second output cam assembly. The second output cam engages the rotor-stator assembly directly.

Abstract: Methods and apparatus to control movement of a component are disclosed herein. An example apparatus includes a housing defining a bore and a piston disposed inside the bore. The piston is to be coupled to a movable component disposed outside of the bore. The example apparatus further includes a fluid flowline in fluid communication with a first chamber of the bore and a second chamber of the bore. The first chamber is on a first side of the piston, and the second chamber on a second side of the piston. The example apparatus also includes a valve to control fluid flow through the fluid flowline. The valve is to be in a first state to enable the piston to dampen movement of the component, and the valve is to be in a second state to enable the piston to hold the component substantially stationary.

Abstract: Provided are half system torque brakes, aircraft utilizing these brakes, and methods of installing these brakes. A half system torque brake includes an input cam assembly slidably disposed on a compression shaft between first and second output cam assemblies. The second output cam assembly is disposed between the input cam assembly and a rotor-stator assembly. When a torque differential between the input cam assembly and either one of the output cam assemblies exceeds its threshold, the same rotor-stator assembly is engaged and prevents further rotation of any cam assembly. Specifically, when the torque differential corresponding to the first output cam assembly exceeds its threshold, this assembly advances away from the input cam assembly and pulls the compression shaft in the same direction, which in turn engages the rotor-stator assembly by advancing the pressure plate to the second output cam assembly. The second output cam engages the rotor-stator assembly directly.

Abstract: A system for optimizing performance of an aircraft may include a flight control computer for computing an optimum flap setting based on aircraft data. The system may further include a flap control system having a flap control device. The system may additionally include a flap actuation system coupled to the flap control system for positioning the trailing edge device at the optimum flap setting.

Abstract: A system for optimizing performance of an aircraft may include a flight control computer for computing an optimum flap setting based on aircraft data. The system may further include a flap control system having a flap control device. The system may additionally include a flap actuation system coupled to the flap control system for positioning the trailing edge device at the optimum flap setting.

Abstract: Methods and apparatus to control movement of a component are disclosed herein. An example apparatus includes a housing defining a bore and a piston disposed inside the bore. The piston is to be coupled to a movable component disposed outside of the bore. The example apparatus further includes a fluid flowline in fluid communication with a first chamber of the bore and a second chamber of the bore. The first chamber is on a first side of the piston, and the second chamber on a second side of the piston. The example apparatus also includes a valve to control fluid flow through the fluid flowline. The valve is to be in a first state to enable the piston to dampen movement of the component, and the valve is to be in a second state to enable the piston to hold the component substantially stationary.

Abstract: A flexible disk drive is disclosed that is optimized for automated manufacture. The critical elements of the disk drive are divided into two functional groups, one of which includes the elements for loading and unloading the disk cartridge and the other of which includes the elements for reading and writing on the flexible disk within the cartridge, with the elements of each group being precisely registered with respect to one another on separate frame members. The frame members are coarsely registered with respect to one another and snapped together, after separate assembly of at least most of the elements on the separate frame members has been completed, and fine position registration of the flexible disk to the spindle is thereafter achieved during each loading operation of a flexible disk into the assembly disk drive by collet centering and clamping the disk to the spindle.

Abstract: Two stage colleting is disclosed for a flexible disk drive. Precise registration of a floppy disk within a disk cartridge with respect to the spindle and recording head of a disk drive is achieved by first positioning the cartridge with respect to the collet, and then aligning the collet with respect to the spindle axis as the collet is moved toward the spindle. This two stage colleting is made possible by use of a collet shaft having two different diameters with the larger diameter being adjacent to the collet during positioning of the cartridge with respect to the collet and with the smaller diameter being adjacent to the collet to allow movement of the collet in a direction normal to the spindle axis during alignment of the collet with respect to the spindle axis.

Abstract: A torsional actuator is disclosed for loading and unloading a flexible disk drive. The actuator includes a torsion beam having a biasing arm and a plurality of actuating arms extending therefrom with the free ends of the actuating arms being separately engageable with different ones of the collet, pressure pad and recording head arm of the flexible disk drive. The arms of the actuator are configured to enable selective and sequential movement of the collet, pressure pad and/or recording head arm in one direction toward a disk within the drive to establish a loaded, or operational, position and in the opposite direction away from a disk within the drive to establish an unloaded, or disk accessing, position with such positioning being determined by a force applying cam engageable with the actuator.

Abstract: An electrochemical cell incorporating cathode materials comprising at least one metal oxide, at least one metal, or mixture of metals or metal oxides incorporated in the matrix of a host metal oxide. The cathode materials of this invention are constructed by the chemical addition, reaction, or otherwise intimate contact of various metal oxides and/or metal elements during thermal treatment in mixed states. The materials thereby produced contain metals and oxides of the groups IB, IIB, IIIB, IVB, VB, VIB, VIIB, and VIII, which includes the noble metals and/or their oxide compounds.The incorporation of the metal oxides, metals or mixtures thereof substantially increases the discharge capacity and the overall performance of the cathode materials.

Abstract: An electrochemical cell incorporating cathode materials comprising at least one metal oxide, at least one metal, or mixture of metals or metal oxides incorporated in the matrix of a host metal oxide. The cathode materials of this invention are constructed by the chemical addition, reaction, or otherwise intimate contact of various metal oxides and/or metal elements during thermal treatment in mixed states. The materials thereby produced contain metals and oxides of the groups IB, IIB, IIIB, IVB, VB, VIB, VIIB, and VIII, which includes the noble metals and/or their oxide compounds.The incorporation of the metal oxides, metals or mixtures thereof substantially increases the discharge capacity and the overall performance of the cathode materials.

Abstract: 1. In a time switch device, electronic means comprising a power supply circuit, a timer circuit, and an output relay circuit, said timer circit cooperating with said power supply circuit to produce an electrical impulse of predetermined periodicity, said output relay circuit being adapted to dispatch said electrical impulse to initiate operation of a stepping means, said stepping means being adapted to control a timed load function, and said stepping means being further adapted to reset said electronic means after each interval of time so that said electrical impulse may be automatically repeated.