Patents by Inventor Robert M. Shimizu

Robert M. Shimizu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prion-specific peptoid reagents
    Publication number: 20120027677
    Abstract: The invention relates to peptoid reagents that interact preferentially with a pathogenic form of a conformational disease protein as compared to a nonpathogenic form of the conformational disease protein where the peptoid reagent comprises an amino-terminal region, a carboxy-terminal region, and at least one peptoid region between the amino-terminal region and the carboxy-terminal region where the peptoid region comprises 3 to about 30 N-substituted glycines, and optionally one or more amino acids. The invention also relates to methods of using the peptoids in detecting and isolating prions, and in the treatment and prevention of prion-related diseases.
    Type: Application
    Filed: October 7, 2010
    Publication date: February 2, 2012
    Inventors: David Peretz, Michael D. Connolly, Ronald Zuckermann, Man Gao, Gulliver Timoteo, Robert M. Shimizu
  • Prion-specific peptoid reagents
    Patent number: 7834144
    Abstract: The invention relates to peptoid reagents that interact preferentially with a pathogenic form of a conformational disease protein as compared to a nonpathogenic form of the conformational disease protein where the peptoid reagent comprises an amino-terminal region, a carboxy-terminal region, and at least one peptoid region between the amino-terminal region and the carboxy-terminal region where the peptoid region comprises 3 to about 30 N-substituted glycines, and optionally one or more amino acids. The invention also relates to methods of using the peptoids in detecting and isolating prions, and in the treatment and prevention of prion-related diseases.
    Type: Grant
    Filed: September 8, 2006
    Date of Patent: November 16, 2010
    Assignee: Novartis AG
    Inventors: David Peretz, Michael D. Connolly, Ronald Zuckermann, Man Gao, Gulliver Timoteo, Robert M. Shimizu