Patents by Inventor Robert M. Winslow

Robert M. Winslow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
    Patent number: 9241979
    Abstract: The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such compositions. Such compositions according to the present invention have better stability to auto oxidation and superior oxygen carrying characteristics.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: January 26, 2016
    Inventors: Robert M. Winslow, Kim D. Vandegriff
  • MalPEG-Hb conjugate-containing compositions for delivering carbon monoxide (CO) to cells
    Patent number: 9138463
    Abstract: The present invention relates to compositions for delivering carbon monoxide (CO) to cells using heme proteins as carriers. In one embodiment, the present invention relates to the use of MalPEG surface modified hemoglobin to deliver CO to cells.
    Type: Grant
    Filed: October 19, 2011
    Date of Patent: September 22, 2015
    Inventors: Robert M. Winslow, Nancy Jo Winslow, Kim Vandegriff, Ashok Malavalli
  • MalPEG Hb conjugate-containing compositions for delivering nitric oxide (NO) to cells
    Patent number: 9138464
    Abstract: The present invention relates to compositions for delivering nitric oxide (NO) to cells using heme proteins as carriers. In one embodiment, the present invention relates to the use of MalPEG surface modified hemoglobin to deliver NO to cells.
    Type: Grant
    Filed: October 19, 2011
    Date of Patent: September 22, 2015
    Inventors: Robert M. Winslow, Kim D. Vandergriff, Nancy Jo Winslow
  • COMPOSITIONS FOR OXYGEN TRANSPORT COMPRISING A HIGH OXYGEN AFFINITY MODIFIED HEMOGLOBIN
    Publication number: 20130288949
    Abstract: The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such compositions. Such compositions according to the present invention have better stability to auto oxidation and superior oxygen carrying characteristics.
    Type: Application
    Filed: June 21, 2013
    Publication date: October 31, 2013
    Inventors: Robert M. Winslow, Kim D. Vandegriff
  • Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
    Patent number: 8377868
    Abstract: The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such compositions. Such compositions according to the present invention have better stability to auto oxidation and superior oxygen carrying characteristics.
    Type: Grant
    Filed: July 11, 2011
    Date of Patent: February 19, 2013
    Assignee: Sangart, Inc.
    Inventors: Robert M. Winslow, Kim D. Vandegriff
  • Method to enhance hemodynamic stability using oxygen carrying compositions
    Patent number: 8278275
    Abstract: The present invention relates to methods for enhancing the hemodynamic stability of an individual undergoing surgery by administering a composition comprising a hemoglobin-based oxygen carrier. In one embodiment, the present invention relates to the use of polyalkylene oxide modified hemoglobins with reduced cooperativity and a high oxygen affinity to enhance oxygen offloading as a preventative measure to avoid hemodynamic stability-related complications during surgery.
    Type: Grant
    Filed: November 23, 2009
    Date of Patent: October 2, 2012
    Assignee: Sangart, Inc.
    Inventors: Robert M. Winslow, Kim D. Vandegriff
  • MalPEG-Hb Conjugate-Containing Compositions for Delivering Carbon Monoxide (CO) to Cells
    Publication number: 20120094912
    Abstract: The present invention relates to compositions for delivering carbon monoxide (CO) to cells using heme proteins as carriers. In one embodiment, the present invention relates to the use of MalPEG surface modified hemoglobin to deliver CO to cells.
    Type: Application
    Filed: October 19, 2011
    Publication date: April 19, 2012
    Applicant: Sangart, Inc.
    Inventors: Robert M. WINSLOW, Kim Vandegriff, Nancy Jo Winslow, Ashok Malavalli
  • MalPEG-Hb Conjugate-Containing Compositions for Delivering Nitric Oxide (NO) to Cells
    Publication number: 20120094936
    Abstract: The present invention relates to compositions for delivering nitric oxide (NO) to cells using heme proteins as carriers. In one embodiment, the present invention relates to the use of MalPEG surface modified hemoglobin to deliver NO to cells.
    Type: Application
    Filed: October 19, 2011
    Publication date: April 19, 2012
    Applicant: Sangart, Inc.
    Inventors: Robert M. Winslow, Nancy Jo Winslow, Kim D. Vandegriff
  • COMPOSITIONS FOR OXYGEN TRANSPORT COMPRISING A HIGH OXYGEN AFFINITY MODIFIED HEMOGLOBIN
    Publication number: 20120004396
    Abstract: The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such compositions. Such compositions according to the present invention have better stability to auto oxidation and superior oxygen carrying characteristics.
    Type: Application
    Filed: July 11, 2011
    Publication date: January 5, 2012
    Applicant: Sangart, Inc.
    Inventors: Robert M. WINSLOW, Kim D. Vandegriff
  • Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
    Patent number: 7989414
    Abstract: The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such compositions. Such compositions according to the present invention have better stability to autooxidation and superior oxygen carrying characteristics.
    Type: Grant
    Filed: November 25, 2009
    Date of Patent: August 2, 2011
    Assignee: Sangart, Inc.
    Inventors: Robert M. Winslow, Kim D. Vandegriff
  • METHODS FOR MAKING HIGH OXYGEN AFFINITY MODIFIED HEMOGLOBIN FOR OXYGEN TRANSPORT
    Publication number: 20100105606
    Abstract: The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such compositions. Such compositions according to the present invention have better stability to autooxidation and superior oxygen carrying characteristics.
    Type: Application
    Filed: November 25, 2009
    Publication date: April 29, 2010
    Applicant: Sangart, Inc.
    Inventors: Robert M. WINSLOW, Kim D. Vandegriff
  • METHOD TO ENHANCE HEMODYNAMIC STABILITY USING OXYGEN CARRYING COMPOSITIONS
    Publication number: 20100087361
    Abstract: The present invention relates to methods for enhancing the hemodynamic stability of an individual undergoing surgery by administering a composition comprising a hemoglobin-based oxygen carrier. In one embodiment, the present invention relates to the use of polyalkylene oxide modified hemoglobins with reduced cooperativity and a high oxygen affinity to enhance oxygen offloading as a preventative measure to avoid hemodynamic stability-related complications during surgery.
    Type: Application
    Filed: November 23, 2009
    Publication date: April 8, 2010
    Inventors: Robert M. WINSLOW, Kim D. Vandegriff
  • Method for making a high oxygen affinity modified hemoglobin for oxygen transport
    Patent number: 7625862
    Abstract: The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such compositions. Such compositions according to the present invention have better stability to autooxidation and superior oxygen carrying characteristics.
    Type: Grant
    Filed: March 13, 2007
    Date of Patent: December 1, 2009
    Assignee: Sangart, Inc.
    Inventors: Robert M. Winslow, Kim D. Vandegriff
  • Method to enhance hemodynamic stability using oxygen carrying compositions
    Patent number: 7622439
    Abstract: The present invention relates to methods for enhancing the hemodynamic stability of an individual undergoing surgery by administering a composition comprising a hemoglobin-based oxygen carrier. In one embodiment, the present invention relates to the use of polyalkylene oxide modified hemoglobins with reduced cooperativity and a high oxygen affinity to enhance oxygen offloading as a preventative measure to avoid hemodynamic stability-related complications during surgery.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: November 24, 2009
    Assignee: Sangart, Inc.
    Inventors: Robert M. Winslow, Kim D. Vandegriff
  • MalPEG-Hb conjugate- containing compositions for delivering carbon monoxide (CO) to cells
    Publication number: 20090082257
    Abstract: The present invention relates to compositions for delivering carbon monoxide (CO) to cells using heme proteins as carriers. In one embodiment, the present invention relates to the use of MalPEG surface modified hemoglobin to deliver CO to cells.
    Type: Application
    Filed: September 18, 2008
    Publication date: March 26, 2009
    Applicant: Sangart, Inc.
    Inventor: Robert M. Winslow
  • METHOD TO ENHANCE HEMODYNAMIC STABILITY USING OXYGEN CARRYING COMPOSITIONS
    Publication number: 20090075866
    Abstract: The present invention relates to methods for enhancing the hemodynamic stability of an individual undergoing surgery by administering a composition comprising a hemoglobin-based oxygen carrier. In one embodiment, the present invention relates to the use of polyalkylene oxide modified hemoglobins with reduced cooperativity and a high oxygen affinity to enhance oxygen offloading as a preventative measure to avoid hemodynamic stability-related complications during surgery.
    Type: Application
    Filed: October 29, 2008
    Publication date: March 19, 2009
    Inventors: Robert M. WINSLOW, Kim D. VANDEGRIFF
  • Methods and Compositions for Simultaneously Isolating Hemoglobin from Red Blood Cells and Inactivating Viruses
    Publication number: 20080138790
    Abstract: The present invention relates to methods arid compositions for isolating hemoglobin from red blood cells. Such methods and compositions also facilitate viral inactivation in a manner that allows recovery of biologically active hemoglobin. More particularly, this method relates to the use of solvents and detergents that are capable of facilitating red blood cell lysis to release hemoglobin (and solubilizing red blood cell membranes), while simultaneously inactivating viruses.
    Type: Application
    Filed: April 12, 2005
    Publication date: June 12, 2008
    Inventors: Robert M. Winslow, Kim D. Vandegriff, Ashok Malavalli
  • Methods and compositions for oxygen transport comprising modified hemoglobin in plasma
    Patent number: 7271145
    Abstract: The present invention relates to blood products, and more particularly to compositions comprising a modified hemoglobin in plasma.
    Type: Grant
    Filed: January 10, 2003
    Date of Patent: September 18, 2007
    Assignee: Sangart, Inc.
    Inventors: Robert M. Winslow, Kim D. Vandegriff
  • Methods and compositions for optimization of oxygen transport by cell-free systems
    Patent number: 7101846
    Abstract: Compositions, and methods of use thereof, for use as blood substitute products comprise aqueous mixtures of oxygen-carrying and non-oxygen carrying plasma expanders and methods for the use thereof. The oxygen-carrying component may consist of any hemoglobin-based oxygen carrier, while the non-oxygen carrying plasma expander my consist of any suitable diluent.
    Type: Grant
    Filed: August 11, 2004
    Date of Patent: September 5, 2006
    Assignee: The Regents of the University of California
    Inventor: Robert M. Winslow
  • Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
    Patent number: 6974795
    Abstract: The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such compositions. Such compositions according to the present invention have better stability to autooxidation and superior oxygen carrying characteristics.
    Type: Grant
    Filed: August 24, 2004
    Date of Patent: December 13, 2005
    Assignee: Sangart, Inc.
    Inventors: Robert M. Winslow, Kim D. Vandegriff