Abstract: The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).

Abstract: The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).

Abstract: The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).

Abstract: The disclosure features methods for treating solid tumor malignancies and lymphomas by administering LNP encapsulated mRNAs encoding human OX40L, IL-23 and IL-36? polypeptides alone or in combination with checkpoint blockade. The disclosure also features compositions for use in the methods.

Abstract: The disclosure features methods for treating ovarian cancer, as well as other cancers such as solid tumors, lymphomas and epithelial origin cancers, by administering mRNA encoding an OX40L polypeptide. The disclosure also features compositions for use in the methods. The disclosure also features combination therapies, such as use of mRNA encoding an OX40L polypeptide in combination with a checkpoint inhibitor, such as an anti-PD-L1 antibody.

Abstract: The disclosure features methods for treating solid tumor malignancies and lymphomas by administering LNP encapsulated mRNAs encoding human OX40L, IL-23 and IL-36y polypeptides alone or in combination with checkpoint blockade. The disclosure also features compositions for use in the methods.

Abstract: UGV bridging system includes a first end of a first elongated span of a hinged bridge structure disposed on a deployment support bracket which is secured to a UGV. A second elongated span is hingedly supported at a second end of the first elongated span opposed from the first end. A tension element applies a tension force to the first elongated span at a location intermediate the first and second ends. The tension force secures the first elongated span in a stowed position adjacent the deployment support bracket. A retention element associated with the deployment support bracket prevents the second elongated span from rotating about the hinge axis in response to a spring bias force. Deployment involves pivoting the first elongated span and concurrently releasing the second elongated span from the retention element in response to the extending.

Abstract: UGV bridging system includes a first end of a first elongated span of a hinged bridge structure disposed on a deployment support bracket which is secured to a UGV. A second elongated span is hingedly supported at a second end of the first elongated span opposed from the first end. A tension element applies a tension force to the first elongated span at a location intermediate the first and second ends. The tension force secures the first elongated span in a stowed position adjacent the deployment support bracket. A retention element associated with the deployment support bracket prevents the second elongated span from rotating about the hinge axis in response to a spring bias force. Deployment involves pivoting the first elongated span and concurrently releasing the second elongated span from the retention element in response to the extending.

Abstract: Systems are provided for positioning passive reflectors, such a lens/mirror assemblies, and other types of reflectors that need to be pointed in a particular direction. The systems can effectuate control of both the elevation and azimuth angles of the reflector. The systems can be configured so that a mount can rotate so as to vary the azimuth angle of the reflector by 360° or more without a need to reverse the direction of rotation of the reflector, and without the use of slip rings, RF rotary joints, or electrical cable wraps.

Abstract: Systems are provided for positioning passive reflectors, such a lens/mirror assemblies, and other types of reflectors that need to be pointed in a particular direction. The systems can effectuate control of both the elevation and azimuth angles of the reflector. The systems can be configured so that a mount can rotate so as to vary the azimuth angle of the reflector by 360° or more without a need to reverse the direction of rotation of the reflector, and without the use of slip rings, RF rotary joints, or electrical cable wraps.

Abstract: Systems are provided for positioning passive reflectors, such a lens/mirror assemblies, and other types of reflectors that need to be pointed in a particular direction. The systems can effectuate control of both the elevation and azimuth angles of the reflector. The systems can be configured so that a mount can rotate so as to vary the azimuth angle of the reflector by 360° or more without a need to reverse the direction of rotation of the reflector, and without the use of slip rings, RF rotary joints, or electrical cable wraps.

Abstract: Systems are provided for positioning passive reflectors, such a lens/mirror assemblies, and other types of reflectors that need to be pointed in a particular direction. The systems can effectuate control of both the elevation and azimuth angles of the reflector. The systems can be configured so that a mount can rotate so as to vary the azimuth angle of the reflector by 360° or more without a need to reverse the direction of rotation of the reflector, and without the use of slip rings, RF rotary joints, or electrical cable wraps.

Abstract: A low-profile antenna system includes a main reflector (102) formed as a shaped main reflector surface that is approximately, but not precisely, parabolic. The main reflector (102) has a main reflector edge configuration (103) that is asymmetric. A feed system (104) for the main reflector includes a subreflector (106) formed as a shaped subreflector surface that is approximately, but not precisely, elliptical. The subreflector has a subreflector edge configuration (107) that is also asymmetric. An RF feed horn (108) associated with the feed system 104 has an aperture profile which also has an asymmetric shape.

Abstract: A generator/sensor may include a pair of arcuate swing arms having respective opposing ends pivotally carried by a base so that the arcuate swing arms are transverse to one another and define a movable crossing point therebetween. A body may be carried by the arcuate swing arms at the crossing point therebetween. At least one electrical generator may be driven by relative movement between the body and the base, such as to generate electrical power or to sense movement, for example. The body may be a pendulum mass or sail responsive to fluid flow.

Abstract: An antenna system includes a base, a turntable rotatably mounted on the base, and an elevation assembly carried on the turntable. An antenna is carried by the elevation assembly. The turntable has an antenna relief opening therein to permit the elevation assembly to position a lower portion of the antenna therein. The antenna system may further include an RF absorbing shroud carried by the turntable and that has an antenna receiving recess to receive the antenna therein. The antenna receiving recess may have lower portions extending into the antenna relief opening of the turntable.

Abstract: A generator/sensor may include a pair of arcuate swing arms having respective opposing ends pivotally carried by a base so that the arcuate swing arms are transverse to one another and define a movable crossing point therebetween. A body may be carried by the arcuate swing arms at the crossing point therebetween. At least one electrical generator may be driven by relative movement between the body and the base, such as to generate electrical power or to sense movement, for example. The body may be a pendulum mass or sail responsive to fluid flow.

Abstract: An inline stacker receives a shingled stream of printed sheet products from a printing press, or finishing equipment, at line speed. A sheet counter at an infeed conveyor section controls the operation of the inline stacker. The infeed conveyor can pivot to a divert position where it feeds the stream to a bi-directional conveyor. A following gap generator section of the stacker has two conveyors with opposed movable ends that are physically separated in the conveying direction by a small gap. The infeed conveyor and gap generator conveyor sections carry the stream at a substantially constant speed, which can be the line speed. To produce a gap in the shingled stream that defines a bundle size, the movable conveyor ends defining the gap between the conveyor gap generator sections move downstream in unison at the speed of the upstream conveyor. At the same time, the speed of the downstream conveyor is briefly increased. The movable ends and the increased conveyor speed then return to their initial status.