Abstract: The present disclosure relates to the endothelin receptor antagonist (ERA) zibotentan in combination with the sodium-dependent glucose cotransporter 2 (SGLT-2) inhibitor dapagliflozin for use in the treatment of certain endothelin related diseases.

Abstract: The present disclosure relates to the endothelin receptor antagonist (ERA) zibotentan in combination with the sodium-dependent glucose cotransporter 2 (SGLT-2) inhibitor dapagliflozin for use in the treatment of certain endothelin related diseases.

Abstract: The present disclosure relates to the endothelin receptor antagonist (ERA) zibotentan in combination with the sodium-dependent glucose cotransporter 2 (SGLT-2) inhibitor dapagliflozin for use in the treatment of certain endothelin related diseases.

Abstract: The disclosure includes, in some embodiments, a filter element that includes a first porous outer layer formed from a nonwoven material, a second porous outer layer formed from a nonwoven material, and at least one inner porous layer formed from a high loft nonwoven material (or other suitable material) disposed between the first porous outer layer and the second porous outer layer. The high loft nonwoven material has a three dimensional matrix formed by entangled and bonded fibers that cooperate to form a plurality of three dimensional interstices between the fibers for maintaining an open and tortuous flow path for fluid to pass through. The filter element also includes filter aid particles dispersed in the interstices of the high loft nonwoven material.

Abstract: The disclosure includes, in some embodiments, a filter element that includes a first porous outer layer formed from a nonwoven material, a second porous outer layer formed from a nonwoven material, and at least one inner porous layer formed from a high loft nonwoven material (or other suitable material) disposed between the first porous outer layer and the second porous outer layer. The high loft nonwoven material has a three dimensional matrix formed by entangled and bonded fibers that cooperate to form a plurality of three dimensional interstices between the fibers for maintaining an open and tortuous flow path for fluid to pass through. The filter element also includes filter aid particles dispersed in the interstices of the high loft nonwoven material.

Abstract: The disclosure includes, in some embodiments, a filter element that includes a first porous outer layer formed from a nonwoven material, a second porous outer layer formed from a nonwoven material, and at least one inner porous layer formed from a high loft nonwoven material (or other suitable material) disposed between the first porous outer layer and the second porous outer layer. The high loft nonwoven material has a three dimensional matrix formed by entangled and bonded fibers that cooperate to form a plurality of three dimensional interstices between the fibers for maintaining an open and tortuous flow path for fluid to pass through. The filter element also includes filter aid particles dispersed in the interstices of the high loft nonwoven material.

Abstract: The disclosure includes, in some embodiments, a filter element that includes a first porous outer layer formed from a nonwoven material, a second porous outer layer formed from a nonwoven material, and at least one inner porous layer formed from a high loft nonwoven material (or other suitable material) disposed between the first porous outer layer and the second porous outer layer. The high loft nonwoven material has a three dimensional matrix formed by entangled and bonded fibers that cooperate to form a plurality of three dimensional interstices between the fibers for maintaining an open and tortuous flow path for fluid to pass through. The filter element also includes filter aid particles dispersed in the interstices of the high loft nonwoven material.

Abstract: An absorbent polymer composition, which can be in the form of a foam, that includes a polymeric material, absorbent particles and thermally expandable (or expanded) microspheres.

Abstract: A conformable adhesive article for use as a sterile medical dressing is described. The article includes a breathable polymeric matrix, a plurality of phases, and an adhesive composition positioned on the polymeric matrix. The plurality of phases preferably provide reinforcement and stiffness to the article. The article permits transport of moisture across the breathable polymeric matrix, preferably at an Inverted water moisture vapor transmission rate of at least 300 g/m2/24 hours.

Abstract: A laminated composite suitable for use in medical products such as tapes and wraps. The composite includes, for example, a first nonwoven fiber layer, an elastic layer, a melt blown adhesive fiber layer, and a second nonwoven fiber layer. A scrim layer serves as a deadstop, or stretch limit, to prevent over stretching. The non-woven fiber layer(s) and/or the scrim layer form suitable loops for a hook and loop fastening system. The scrim layer in some embodiments is employed to make the composite finger tearable. The melt blown adhesive layer, nonwoven web layer and elastic layer form a breathable, porous elastic composite. Methods of manufacturing the composite are also disclosed.