Patents by Inventor Robert Michael Hughes

Robert Michael Hughes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR THE SYNTHESIS OF PROTEIN-DRUG CONJUGATES
    Publication number: 20240024497
    Abstract: The present invention relates to methods for the synthesis of conjugates useful for the treatment of viral infections, e.g., conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir or an analog thereof) linked to an Fc domain monomer.
    Type: Application
    Filed: August 6, 2021
    Publication date: January 25, 2024
    Inventors: Allen BORCHARDT, Robert Michael HUGHES
  • METHODS FOR THE SYNTHESIS OF PROTEIN-DRUG CONJUGATES
    Publication number: 20230364251
    Abstract: The present invention relates to intermediates and methods for synthesizing protein-drug conjugates that can be used for the treatment of diseases and related conditions.
    Type: Application
    Filed: August 6, 2021
    Publication date: November 16, 2023
    Inventors: Allen BORCHARDT, Robert Michael HUGHES
  • SYNTHESIS OF ECHINOCANDIN ANTIFUNGAL AGENT
    Publication number: 20230365629
    Abstract: The present invention relates to echinocandin cyclopeptides and to methods for preparing echinocandin cyclopeptides.
    Type: Application
    Filed: December 8, 2022
    Publication date: November 16, 2023
    Inventors: David HUGHES, Martin Patrick HUGHES, Balasingam RADHAKRISHNAN, Robert Michael HUGHES, Yannick BORGUET, Steven MCINTYRE
  • Synthesis of echinocandin antifungal agent
    Patent number: 11524980
    Abstract: The present invention relates to echinocandin cyclopeptides and to methods for preparing echinocandin cyclopeptides.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: December 13, 2022
    Assignee: Cidara Therapeutics, Inc.
    Inventors: David Hughes, Martin Patrick Hughes, Robert Michael Hughes, Balasingam Radhakrishnan, Yannick Borguet, Steven McIntyre
  • Processes for the preparation of uracil derivatives
    Patent number: 11459305
    Abstract: The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: January 10, 2020
    Date of Patent: October 4, 2022
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Donald J. Gallagher, Laszlo R. Treiber, Robert Michael Hughes, Onorato Campopiano, Peng Wang, Yuxin Zhao, Shine K. Chou, Michael Allen Ouellette, Donald Nicholas Hettinger
  • POLYMORPH OF ECHINOCANDIN ANTIFUNGAL AGENT
    Publication number: 20210355165
    Abstract: The present invention relates to crystalline polymorphs of an echinocandin antifungal agent and novel methods for their preparation.
    Type: Application
    Filed: October 25, 2019
    Publication date: November 18, 2021
    Inventors: Martin Patrick HUGHES, Robert Michael HUGHES, Yannick BORGUET, Cen CHEN, Jianwei SHEN, Alan THOMPSON, Tracy WALKER, Yanfeng ZHANG
  • PROCESS OF PRODUCING CYCLOALKYLCARBOXAMIDO-INDOLE COMPOUNDS
    Publication number: 20210238158
    Abstract: The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1), useful for treating CFTR mediated diseases such as cystic fibrosis.
    Type: Application
    Filed: August 26, 2020
    Publication date: August 5, 2021
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Gerald J. Tanoury, Cristian Harrison, Benjamin Joseph Littler, Peter Jamison Rose, Robert Michael Hughes, Young Chun Jung, David Andrew Siesel, Elaine Chungmin Lee, Daniel T. Belmont, William A. Nugent
  • SYNTHESIS OF ECHINOCANDIN ANTIFUNGAL AGENT
    Publication number: 20210179667
    Abstract: The present invention relates to echinocandin cyclopeptides and to methods for preparing echinocandin cyclopeptides.
    Type: Application
    Filed: June 14, 2019
    Publication date: June 17, 2021
    Inventors: David HUGHES, Martin Patrick HUGHES, Robert Michael HUGHES, Balasingam RADHAKRISHNAN, Yannick BORGUET, Steven MCINTYRE
  • Processes for preparing ATR inhibitors
    Patent number: 10822331
    Abstract: The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: November 3, 2020
    Assignee: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Jean-Damien Charrier, John Studley, Francoise Yvonne Theodora Marie Pierard, Steven John Durrant, Benjamin Joseph Littler, Robert Michael Hughes, David Andrew Siesel, Paul Angell, Armando Urbina, Yi Shi
  • PROCESSES FOR THE PREPARATION OF URACIL DERIVATIVES
    Publication number: 20200255387
    Abstract: The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: January 10, 2020
    Publication date: August 13, 2020
    Inventors: Donald J. GALLAGHER, Laszlo R. TREIBER, Robert Michael HUGHES, Onorato CAMPOPIANO, Peng WANG, Yuxin ZHAO, Shine K. CHOU, Michael Allen OUELLETTE, Donald Nicholas HETTINGER
  • Processes for the preparation of uracil derivatives
    Patent number: 10494347
    Abstract: The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: December 3, 2019
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Donald J. Gallagher, Laszlo R. Treiber, Robert Michael Hughes, Onorato Campopiano, Peng Wang, Yuxin Zhao, Shine K. Chou, Michael Allen Ouellette, Donald Nicholas Hettinger
  • Processes for preparing ATR inhibitors
    Patent number: 10435397
    Abstract: The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: October 8, 2019
    Assignee: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Jean-Damien Charrier, John Studley, Francoise Yvonne Theodora Marie Pierard, Steven John Durrant, Benjamin Joseph Littler, Robert Michael Hughes, David Andrew Siesel, Paul Angell, Armando Urbina, Yi Shi
  • PROCESSES FOR THE PREPARATION OF URACIL DERIVATIVES
    Publication number: 20190218191
    Abstract: The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: June 27, 2018
    Publication date: July 18, 2019
    Inventors: Donald J. Gallagher, Laszlo R. Treiber, Robert Michael Hughes, Onorato Campopiano, Peng Wang, Yuxin Zhao, Shine K. Chou, Michael Allen Ouellette, Donald Nicholas Hettinger
  • PROCESS OF PRODUCING CYCLOALKYLCARBOXAMIDO-INDOLE COMPOUNDS
    Publication number: 20190210991
    Abstract: The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)—N—(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1), useful for treating CFTR mediated diseases such as cystic fibrosis.
    Type: Application
    Filed: August 9, 2018
    Publication date: July 11, 2019
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Gerald J. Tanoury, Cristian Harrison, Benjamin Joseph Littler, Peter Jamison Rose, Robert Michael Hughes, Young Chun Jung, David Andrew Siesel, Elaine Chungmin Lee, Daniel T. Belmont, William A. Nugent
  • PROCESSES FOR PREPARING ATR INHIBITORS
    Publication number: 20190202818
    Abstract: The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I or II: wherein the variables are as defined herein.
    Type: Application
    Filed: December 27, 2018
    Publication date: July 4, 2019
    Inventors: Jean-Damien Charrier, John Studley, Francoise Yvonne Theodora Marie Pierard, Steven John Durrant, Benjamin Joseph Littler, Robert Michael Hughes, David Andrew Siesel, Paul Angell, Armando Urbina, Yi Shi
  • Processes for preparing ATR inhibitors
    Patent number: 10208027
    Abstract: The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I or II: wherein the variables are as defined herein.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: February 19, 2019
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jean-Damien Charrier, John Studley, Francoise Yvonne Theodora Marie Pierard, Steven John Durrant, Benjamin Joseph Littler, Robert Michael Hughes, David Andrew Siesel, Paul Angell, Armando Urbina, Yi Shi
  • PROCESSES FOR THE PREPARATION OF URACIL DERIVATIVES
    Publication number: 20180346428
    Abstract: The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: December 6, 2017
    Publication date: December 6, 2018
    Inventors: Donald J. Gallagher, Laszio R. Treiber, Robert Michael Hughes, Onorato Campopiano, Peng Wang, Yuxin Zhao, Shine K. Chou, Michael Allen Ouellette, Donald Nicholas Hettinger
  • Process of producing cycloalkylcarboxamido-indole compounds
    Patent number: 10071979
    Abstract: The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1), useful for treating CFTR mediated diseases such as cystic fibrosis.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: September 11, 2018
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Gerald J. Tanoury, Cristian Harrison, Benjamin Joseph Littler, Peter Jamison Rose, Robert Michael Hughes, Young Chun Jung, David Andrew Siesel, Elaine Chungmin Lee, Daniel T. Belmont, William A. Nugent
  • PROCESSES FOR PREPARING ATR INHIBITORS
    Publication number: 20180244662
    Abstract: The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I or II: wherein the variables are as defined herein.
    Type: Application
    Filed: December 20, 2017
    Publication date: August 30, 2018
    Inventors: Jean-Damien Charrier, John Studley, Francoise Yvonne Theodora Marie Pierard, Steven John Durrant, Benjamin Joseph Littler, Robert Michael Hughes, David Andrew Siesel, Paul Angell, Armando Urbina, Yi Shi
  • Processes for the preparation of uracil derivatives
    Patent number: 9868706
    Abstract: The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: January 16, 2018
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Donald J. Gallagher, Laszlo R. Treiber, Robert Michael Hughes, Onorato Campopiano, Peng Wang, Yuxin Zhao, Shine K. Chou, Michael Allen Ouellette, Donald Nicholas Hettinger