Patents by Inventor Robert Nordmeyer
Robert Nordmeyer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8283181Abstract: This invention provides improved components (e.g. array “pins”, print head, substrate platen, print head platen, and the like) for microarray printing devices as well as microarray printing devices incorporating such components. In one embodiment, this invention provides a microarray print head comprising a plurality of glass or quartz spotting capillaries disposed in a support that maintains a fixed spacing between the spotting capillaries and that permits the spotting capillaries to move in a direction parallel to the long axis of the capillaries.Type: GrantFiled: July 9, 2008Date of Patent: October 9, 2012Assignee: The Regents of the University of CaliforniaInventors: Daniel Pinkel, Donna G. Albertson, Greg Hamilton, Nils W. Brown, Robert Nordmeyer
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Publication number: 20120043208Abstract: A multi-channel gel electrophoresis apparatus for efficiently collecting molecules isolated by gel electrophoresis so they can be further analyzed, identified, or used as reagents or medications. The apparatus using a novel “tagless” strategy that combines multi-dimensional separation of endogenous complexes with mass spectrometric monitoring of their composition. In this procedure, putative protein complexes are identified based on the co-migration of collections of polypeptides through multiple orthogonal separation steps. A majority of E. coli proteins are shown to remain in stable complexes during fractionation of a crude extract through three chromatographic steps.Type: ApplicationFiled: July 5, 2011Publication date: February 23, 2012Applicant: The Regents of the University of CaliforniaInventors: Jian Jin, Mark D. Biggin, Robert A. Nordmeyer, Ming Dong, Earl W. Cornell, Megan Choi, Halina Ewa Witkowski, Bong-Gyoon Han, Robert M. Glaeser
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Publication number: 20090029876Abstract: This invention provides improved components (e.g. array “pins”, print head, substrate platen, print head platen, and the like) for microarray printing devices as well as microarray printing devices incorporating such components. In one embodiment, this invention provides a microarray print head comprising a plurality of glass or quartz spotting capillaries disposed in a support that maintains a fixed spacing between the spotting capillaries and that permits the spotting capillaries to move in a direction parallel to the long axis of the capillaries.Type: ApplicationFiled: July 9, 2008Publication date: January 29, 2009Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Daniel Pinkel, Donna G. Albertson, Greg Hamilton, Nils W. Brown, Robert Nordmeyer
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Publication number: 20080181834Abstract: A method is provided for performing array microcrystallizations to determine suitable crystallization conditions for a molecule, the method comprising: forming an array of microcrystallizations, each microcrystallization comprising a drop comprising a mother liquor solution whose composition varies within the array and a molecule to be crystallized, the drop having a volume of less than 1 microliter; storing the array of microcrystallizations under conditions suitable for molecule crystals to form in the drops in the array; and detecting molecule crystal formation in the drops by taking images of the drops.Type: ApplicationFiled: December 21, 2007Publication date: July 31, 2008Inventors: Bernard D. Santarsiero, Derek T. Yegian, Robert A. Nordmeyer, Earl W. Cornell, Joseph M. Jaklevic, Peter G. Schultz, Raymond C. Stevens
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Patent number: 7402286Abstract: This invention provides improved components (e.g. array “pins”, print head, substrate platen, print head platen, and the like) for microarray printing devices as well as microarray printing devices incorporating such components. In one embodiment, this invention provides a microarray print head comprising a plurality of glass or quartz spotting capillaries disposed in a support that maintains a fixed spacing between the spotting capillaries and that permits the spotting capillaries to move in a direction parallel to the long axis of the capillaries.Type: GrantFiled: December 15, 2004Date of Patent: July 22, 2008Assignee: The Regents of the University of CaliforniaInventors: Daniel Pinkel, Donna G. Albertson, Greg Hamilton, Nils W. Brown, Robert Nordmeyer
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Publication number: 20070228049Abstract: A method and apparatus for the transportation, remote and unattended mounting, and visual alignment and monitoring of protein crystals for synchrotron generated x-ray diffraction analysis. The protein samples are maintained at liquid nitrogen temperatures at all times: during shipment, before mounting, mounting, alignment, data acquisition and following removal. The samples must additionally be stably aligned to within a few microns at a point in space. The ability to accurately perform these tasks remotely and automatically leads to a significant increase in sample throughput and reliability for high-volume protein characterization efforts. Since the protein samples are placed in a shipping-compatible layered stack of sample cassettes each holding many samples, a large number of samples can be shipped in a single cryogenic shipping container.Type: ApplicationFiled: June 7, 2007Publication date: October 4, 2007Inventors: Robert Nordmeyer, Gyorgy Snell, Earl Cornell, William Kolbe, Derek Yegian, Thomas Earnest, Joseph Jaklevic, Carl Cork, Bernard Santarsiero, Raymond Stevens
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Patent number: 7274769Abstract: A method and apparatus for the transportation, remote and unattended mounting, and visual alignment and monitoring of protein crystals for synchrotron generated x-ray diffraction analysis. The protein samples are maintained at liquid nitrogen temperatures at all times: during shipment, before mounting, mounting, alignment, data acquisition and following removal. The samples must additionally be stably aligned to within a few microns at a point in space. The ability to accurately perform these tasks remotely and automatically leads to a significant increase in sample throughput and reliability for high-volume protein characterization efforts. Since the protein samples are placed in a shipping-compatible layered stack of sample cassettes each holding many samples, a large number of samples can be shipped in a single cryogenic shipping container.Type: GrantFiled: February 22, 2005Date of Patent: September 25, 2007Assignee: The Regents of the University of CaliforniaInventors: Robert A. Nordmeyer, Gyorgy P. Snell, Earl W. Cornell, William F. Kolbe, Derek T. Yegian, Thomas N. Earnest, Joseph M. Jaklevich, Carl W. Cork, Bernard D. Santarsiero, Raymond C. Stevens
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Patent number: 7015041Abstract: A method is provided for performing array microcrystallizations to determine suitable crystallization conditions for a molecule, the method comprising: forming an array of microcrystallizations, each microcrystallization comprising a drop comprising a mother liquor solution whose composition varies within the array and a molecule to be crystallized, the drop having a volume of less than 1 microliter; storing the array of microcrystallizations under conditions suitable for molecule crystals to form in the drops in the array; and detecting molecule crystal formation in the drops by taking images of the drops.Type: GrantFiled: December 31, 2002Date of Patent: March 21, 2006Assignee: The Regents of the University of CaliforniaInventors: Bernard D. Santarsiero, Raymond C. Stevens, Peter G. Schultz, Joseph M. Jaklevic, Derek T. Yegian, Earl W. Cornell, Robert A. Nordmeyer
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Patent number: 7001438Abstract: A method is provided for forming crystallization experiments for a molecule, the method comprising forming a plurality of crystallization experiments that comprise a molecule to be crystallized and a composition that varies among the plurality of crystallization experiments, the crystallization experiments having a volume less than 1 microliter, the volumes of the plurality of crystallization experiments varying among the experiments by less than 25 nL.Type: GrantFiled: April 8, 2002Date of Patent: February 21, 2006Assignee: The Regents of the University of CaliforniaInventors: Bernard D. Santarsiero, Raymond C. Stevens, Peter G. Schultz, Joseph M. Jaklevic, Derek T. Yegian, Earl W. Cornell, Robert A. Nordmeyer
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Patent number: 6951575Abstract: A method is provided for performing array microcrystallizations to determine suitable crystallization conditions for a molecule, the method comprising: forming an array of microcrystallizations, each microcrystallization comprising a drop comprising a mother liquor solution whose composition varies within the array and a molecule to be crystallized, the drop having a volume of less than 1 microliter; storing the array of microcrystallizations under conditions suitable for molecule crystals to form in the drops in the array; and detecting molecule crystal formation in the drops by taking images of the drops.Type: GrantFiled: December 18, 2002Date of Patent: October 4, 2005Assignee: The Regents of the University of CaliforniaInventors: Bernard D. Santarsiero, Raymond C. Stevens, Peter G. Schultz, Joseph M. Jaklevic, Derek T. Yegian, Earl W. Cornell, Robert A. Nordmeyer
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Patent number: 6932845Abstract: A method is provided for performing crystallization experiments for a molecule, the method comprising performing a plurality of crystallization experiments where the crystallization experiments have volumes of less than 1 microliter, the crystallization experiments comprising a molecule to be crystallized and a composition that varies among the plurality of crystallization experiments detecting crystal formation in the crystallization experiments.Type: GrantFiled: April 8, 2002Date of Patent: August 23, 2005Assignee: The Regents of the University of CaliforniaInventors: Bernard D. Santarsiero, Raymond C. Stevens, Peter G. Schultz, Joseph M. Jaklevic, Derek T. Yegian, Earl W. Cornell, Robert A. Nordmeyer
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Publication number: 20050169808Abstract: This invention provides improved components (e.g. array “pins”, print head, substrate platen, print head platen, and the like) for microarray printing devices as well as microarray printing devices incorporating such components. In one embodiment, this invention provides a microarray print head comprising a plurality of glass or quartz spotting capillaries disposed in a support that maintains a fixed spacing between the spotting capillaries and that permits the spotting capillaries to move in a direction parallel to the long axis of the capillaries.Type: ApplicationFiled: December 15, 2004Publication date: August 4, 2005Inventors: Daniel Pinkel, Donna Albertson, Greg Hamilton, Nils Brown, Robert Nordmeyer
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Publication number: 20050163280Abstract: A method and apparatus for the transportation, remote and unattended mounting, and visual alignment and monitoring of protein crystals for synchrotron generated x-ray diffraction analysis. The protein samples are maintained at liquid nitrogen temperatures at all times: during shipment, before mounting, mounting, alignment, data acquisition and following removal. The samples must additionally be stably aligned to within a few microns at a point in space. The ability to accurately perform these tasks remotely and automatically leads to a significant increase in sample throughput and reliability for high-volume protein characterization efforts. Since the protein samples are placed in a shipping-compatible layered stack of sample cassettes each holding many samples, a large number of samples can be shipped in a single cryogenic shipping container.Type: ApplicationFiled: February 22, 2005Publication date: July 28, 2005Inventors: Robert Nordmeyer, Gyorgy Snell, Earl Cornell, William Kolbe, Derek Yegian, Thomas Earnest, Joseph Jaklevic, Carl Cork, Bernard Santarsiero, Raymond Stevens
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Patent number: 6918698Abstract: A method and apparatus for the transportation, remote and unattended mounting, and visual alignment and monitoring of protein crystals for synchrotron generated x-ray diffraction analysis. The protein samples are maintained at liquid nitrogen temperatures at all times: during shipment, before mounting, mounting, alignment, data acquisition and following removal. The samples must additionally be stably aligned to within a few microns at a point in space. The ability to accurately perform these tasks remotely and automatically leads to a significant increase in sample throughput and reliability for high-volume protein characterization efforts. Since the protein samples are placed in a shipping-compatible layered stack of sample cassettes each holding many samples, a large number of samples can be shipped in a single cryogenic shipping container.Type: GrantFiled: December 12, 2002Date of Patent: July 19, 2005Assignee: The Regents of the University of CaliforniaInventors: Robert A. Nordmeyer, Gyorgy P. Snell, Earl W. Cornell, William Kolbe, Derek Yegian, Thomas N. Earnest, Joseph M. Jaklevic, Carl W. Cork, Bernard D. Santarsiero, Raymond C. Stevens
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Patent number: 6911056Abstract: A method is provided for characterizing a crystal structure of a molecule, the method comprising performing a plurality of crystallization experiments where the crystallization experiments have volumes of less than 1 microliter, the crystallization experiments comprising a molecule to be crystallized and a composition that varies among the plurality of crystallization experiments and diffracting a crystal formed in one of the crystallization experiments.Type: GrantFiled: April 8, 2002Date of Patent: June 28, 2005Assignee: The Regents of the University of CaliforniaInventors: Bernard D. Santarsiero, Raymond C. Stevens, Peter G. Schultz, Joseph M. Jaklevic, Derek T. Yegian, Earl W. Cornell, Robert A. Nordmeyer
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Patent number: 6630006Abstract: A method is provided for performing array microcrystallizations to determine suitable crystallization conditions for a molecule, the method comprising: forming an array of microcrystallizations, each microcrystallization comprising a drop comprising a mother liquor solution whose composition varies within the array and a molecule to be crystallized, the drop having a volume of less than 1 microliter; storing the array of microcrystallizations under conditions suitable for molecule crystals to form in the drops in the array; and detecting molecule crystal formation in the drops by taking images of the drops.Type: GrantFiled: May 7, 2001Date of Patent: October 7, 2003Assignee: The Regents of the University of CaliforniaInventors: Bernard D. Santarsiero, Raymond C. Stevens, Peter G. Schultz, Joseph M. Jaklevic, Derek T. Yegian, Earl W. Cornell, Robert A. Nordmeyer
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Publication number: 20030152194Abstract: A method and apparatus for the transportation, remote and unattended mounting, and visual alignment and monitoring of protein crystals for synchrotron generated x-ray diffraction analysis. The protein samples are maintained at liquid nitrogen temperatures at all times: during shipment, before mounting, mounting, alignment, data acquisition and following removal. The samples must additionally be stably aligned to within a few microns at a point in space. The ability to accurately perform these tasks remotely and automatically leads to a significant increase in sample throughput and reliability for high-volume protein characterization efforts. Since the protein samples are placed in a shipping-compatible layered stack of sample cassettes each holding many samples, a large number of samples can be shipped in a single cryogenic shipping container.Type: ApplicationFiled: December 12, 2002Publication date: August 14, 2003Applicant: The Regents of the University of CaliforniaInventors: Robert A. Nordmeyer, Gyorgy P. Snell, Earl W. Cornell, William Kolbe, Derek Yegian, Thomas N. Earnest, Joseph M. Jaklevic, Carl W. Cork, Bernard D. Santarsiero, Raymond C. Stevens
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Publication number: 20030119048Abstract: A method is provided for performing array microcrystallizations to determine suitable crystallization conditions for a molecule, the method comprising: forming an array of microcrystallizations, each microcrystallization comprising a drop comprising a mother liquor solution whose composition varies within the array and a molecule to be crystallized, the drop having a volume of less than 1 microliter; storing the array of microcrystallizations under conditions suitable for molecule crystals to form in the drops in the array; and detecting molecule crystal formation in the drops by taking images of the drops.Type: ApplicationFiled: December 31, 2002Publication date: June 26, 2003Inventors: Bernard D. Santarsiero, Raymond C. Stevens, Peter G. Schultz, Joseph M. Jaklevic, Derek T. Yegian, Earl W. Cornell, Robert A. Nordmeyer
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Publication number: 20030113804Abstract: A method is provided for performing array microcrystallizations to determine suitable crystallization conditions for a molecule, the method comprising: forming an array of microcrystallizations, each microcrystallization comprising a drop comprising a mother liquor solution whose composition varies within the array and a molecule to be crystallized, the drop having a volume of less than 1 microliter; storing the array of microcrystallizations under conditions suitable for molecule crystals to form in the drops in the array; and detecting molecule crystal formation in the drops by taking images of the drops.Type: ApplicationFiled: December 31, 2002Publication date: June 19, 2003Inventors: Bernard D. Santarsiero, Raymond C. Stevens, Peter G. Schultz, Joseph M. Jaklevic, Derek T. Yegian, Earl W. Cornell, Robert A. Nordmeyer
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Publication number: 20030109065Abstract: A method is provided for performing array microcrystallizations to determine suitable crystallization conditions for a molecule, the method comprising: forming an array of microcrystallizations, each microcrystallization comprising a drop comprising a mother liquor solution whose composition varies within the array and a molecule to be crystallized, the drop having a volume of less than 1 microliter; storing the array of microcrystallizations under conditions suitable for molecule crystals to form in the drops in the array; and detecting molecule crystal formation in the drops by taking images of the drops.Type: ApplicationFiled: December 18, 2002Publication date: June 12, 2003Inventors: Bernard D. Santarsiero, Raymond C. Stevens, Peter G. Schultz, Joseph M. Jaklevic, Derek T. Yegian, Earl W. Cornell, Robert A. Nordmeyer