Abstract: The present disclosure relates to immunogenic compositions comprising at least one Yersinia pestis (Y. pestis) antigen, an aluminum salt adjuvant, and an oligonucleotide comprising an unmethylated cytidine-phospho-guanosine (CpG) motif. The immunogenic compositions are suitable for stimulating an immune response against Y. pestis in a subject in need thereof. The present disclosure also relates to kits and methods using the immunogenic compositions, or two separate compositions which together comprise the antigen, the aluminum salt adjuvant, and the oligonucleotide.

Abstract: The present disclosure relates to compounds that act as agonists of, or otherwise modulate the activity of, GPR131 and to their use in the treatment of various diseases. In particular embodiments, the structure of the compounds is given by Formula I: wherein the variables are as described herein. Related compositions, formulations and methods for the preparation of compounds of formula I are also described.

Abstract: Chemical compounds which act as agonists of, or otherwise modulate the activity of, GPR131 are disclosed. Related compositions, formulations and methods of use are also described.

Abstract: Chemical compounds which act as agonists of, or otherwise modulate the activity of, GPR131 are disclosed. Related compositions, formulations and methods of use are also described.

Abstract: The present disclosure relates to compounds that act as agonists of, or otherwise modulate the activity of, GPR131 and to their use in the treatment of various diseases. In particular embodiments, the structure of the compounds is given by Formula I: wherein the variables are as described herein. Related compositions, formulations and methods for the preparation of compounds of formula I are also described.

Abstract: A convertible wheeled chair is easily changed by an attendant into a gurney of the same height as a patient bed. During the process of transferring a patient from an upright position to a reclining position, convertible wheeled chair shifts the center of gravity of the patient rearwardly, and therefore does not give the patient a sensation of sliding from the chair.

Abstract: A convertible wheeled chair is easily changed by an attendant into a gurney of the same height as a patient bed. During the process of transferring a patient from an upright position to a reclining position, convertible wheeled chair shifts the center of gravity of the patient rearwardly, and therefore does not give the patient a sensation of sliding from the chair.

Abstract: A pressure control apparatus for use in a bed including a pressurized air source, an inflatable air sack, and an independently inflatable cell located adjacent the inflatable air sack. A controller is operable to regulate the pressure in the air sack and to independently alternately pressurize and vent the inflatable cell at a selected frequency.