Abstract: The application relates to biological components, methods, systems, and kits for modulating immune responses. The disclosed biological components include genetically modified cells comprising an inserted exogenous sequence in a major histocompatibility complex (MHC)-associated gene. The inserted exogenous sequence encodes a peptide and the genetically modified cells express a fusion protein comprising the peptide and at least a portion of the polypeptide encoded by the MHC-associated gene to form a modified MHC complex. The genetically modified cells may present the peptide as an antigen associated with the MHC complex and may be utilized in methods for modulating T cell activity, inducing an immune response, and inducing a tolerogenic response. As such, the disclosed biological components, methods, systems, and kits may be utilized in order to treat and/or prevent a disease or disorder in a subject in need thereof and to screen and validate clinically relevant antigens.

Abstract: A three-dimensional print head apparatus may include a securing mechanism, a hopper, a nozzle, a heating system, and a fume extraction system. The securing mechanism may be adapted to secure to a wrist joint of a robotic arm. The hopper may have a cavity and a lower aperture and may be secured to the securing mechanism. The nozzle may have an upper aperture and a lower aperture. The heating system may be positioned along the barrel.

Abstract: An optics-integrated confinement apparatus system comprises a confinement apparatus chip having a confinement apparatus formed thereon and having at least one apparatus optical element disposed and/or formed thereon.

Abstract: A serving caddy with perimetral cutout holsters is provided. The perimetral cutout holsters are cutouts of the body of the serving caddy, wherein the cutout communicates with the body's periphery defining a gap of the periphery. Each cutout holster is dimensioned and adapted to slidably receive a bottom of conical, tapering container in an unengaged state though when the serving caddy is raised relative to the container, the cutout holster and the container form and engaged state along an upper half of the container's sidewall. The serving caddy has a centrally disposed handle cutout pair that defines a cross bar or handle portion, enabling a secure grip of the serving caddy simply by singlehandedly grabbing the handle portion, whereby the serving caddy is secure the instant it is lifted off a supporting surface.

Abstract: A hitch-mountable, vehicle load carrying apparatus and method is herein disclosed. The device includes a base load-carrying platform, and a vertical support structure connected to a horizontal crossbar structure that is adjustable in height. The device further includes several transverse bars that are also adjustable for secure fitting to the equipment that is to be transported. An exemplary embodiment includes wheels connected to the load-carrying platform for convenient stowage of equipment without physical removal from the device.