Patents by Inventor Robert O. Dempcy

Robert O. Dempcy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alkyl amine compounds for fluorescent labeling
    Patent number: 9062205
    Abstract: Alkyl amine dyes, oligonucleotide probes prepared from the alkyl amine dyes, phosphoramidites and solid supports prepared from the alkyl amine dyes, and methods of labeling biological agents using the alkyl amine dyes.
    Type: Grant
    Filed: May 29, 2012
    Date of Patent: June 23, 2015
    Assignee: Blood Cell Storage, Inc.
    Inventors: Michael W. Reed, Robert O. Dempcy
  • Fluorescent pH detector system and related methods
    Patent number: 9040307
    Abstract: Fluorescent pH detector and methods for measuring pH using the fluorescent pH detector.
    Type: Grant
    Filed: May 29, 2012
    Date of Patent: May 26, 2015
    Assignee: Blood Cell Storage, Inc.
    Inventors: Michael W. Reed, Steven J. Geelhood, Robert O. Dempcy
  • FLUORESCENT COMPOUNDS, COMPOSITIONS, AND METHODS FOR USING THE COMPOUNDS AND COMPOSITIONS
    Publication number: 20130130402
    Abstract: Low pKa fluorescent compounds, compositions that include the compounds, bioconjugates made from the compounds, and methods for making and using the compounds and bioconjugates.
    Type: Application
    Filed: May 22, 2012
    Publication date: May 23, 2013
    Applicant: BLOOD CELL STORAGE, INC.
    Inventors: Michael W. Reed, Robert O. Dempcy
  • FLUORESCENT pH DETECTOR SYSTEM AND RELATED METHODS
    Publication number: 20120322161
    Abstract: Fluorescent pH detector and methods for measuring pH using the fluorescent pH detector.
    Type: Application
    Filed: May 29, 2012
    Publication date: December 20, 2012
    Applicant: BLOOD CELL STORAGE, INC.
    Inventors: Michael W. Reed, Steven J. Geelhood, Robert O. Dempcy
  • ALKYL AMINE COMPOUNDS FOR FLUORESCENT LABELING
    Publication number: 20120301880
    Abstract: Alkyl amine dyes, oligonucleotide probes prepared from the alkyl amine dyes, phosphoramidites and solid supports prepared from the alkyl amine dyes, and methods of labeling biological agents using the alkyl amine dyes.
    Type: Application
    Filed: May 29, 2012
    Publication date: November 29, 2012
    Applicant: BLOOD CELL STORAGE, INC.
    Inventors: Michael W. Reed, Robert O. Dempcy
  • Fluorescent quenching detecting reagents and methods
    Patent number: 7897736
    Abstract: Oligonucleotide probes containing two labels are provided and are useful in hybridization assays. The probes can also contain a minor groove binding group.
    Type: Grant
    Filed: January 6, 2010
    Date of Patent: March 1, 2011
    Assignee: Elitech Holding B.V.
    Inventors: Michael W. Reed, Eugeny Alexander Lukhtanov, Alexander A. Gall, Robert O. Dempcy, Nicolaas M. J. Vermeulen
  • FLUORESCENT QUENCHING DETECTING REAGENTS AND METHODS
    Publication number: 20100174058
    Abstract: Oligonucleotide probes containing two labels are provided and are useful in hybridization assays. The probes can also contain a minor groove binding group.
    Type: Application
    Filed: January 6, 2010
    Publication date: July 8, 2010
    Inventors: Michael W. Reed, Eugeny Alexander Lukhtanov, Alexander A. Gall, Robert O. Dempcy, Nicolaas M.J. Vermeulen
  • TM leveling methods
    Patent number: 7751982
    Abstract: Methods for designing an oligonucleotide sequence having a selected duplex stability are provided wherein the oligonucleotide portion comprises at least one modified base selected from universal bases, unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally having attached minor groove binders and reporter groups.
    Type: Grant
    Filed: September 26, 2003
    Date of Patent: July 6, 2010
    Assignee: Elitech Holding B.V.
    Inventors: Robert O. Dempcy, Alexander A. Gall, Sergey G. Lokhov, Irina A. Afonina, Igor V. Kutyavin, Nicolaas M. J. Vermeulen
  • Single nucleotide polymorphism analysis of highly polymorphic target sequences
    Patent number: 7718374
    Abstract: Methods and probes are provided for the analysis of target sequences having two or more polymorphisms wherein one of the polymorphisms is to be distinguished and another polymorphism is to be masked.
    Type: Grant
    Filed: January 28, 2008
    Date of Patent: May 18, 2010
    Assignee: Elitech Holding B.V.
    Inventors: Yevgeniy Belousov, Robert O. Dempcy, Sergey G. Lokhov, Alexei Vorobiev
  • Systems and methods for predicting oligonucleotide melting temperature (TS)
    Patent number: 7715989
    Abstract: Software systems and methods for predicting the melting temperature (Tm) and other characteristics of oligonucleotides, including modified oligonucleotides. Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor groove binders and reporter groups.
    Type: Grant
    Filed: June 18, 2002
    Date of Patent: May 11, 2010
    Assignee: Elitech Holding B.V.
    Inventors: Robert O. Dempcy, Alexander A. Gall, Sergey G. Lokhov, Irina A. Afonina, Michael J. Singer, Karen M. Singer, legal representative, Igor V. Kutyavin, Nicolaas M. J. Vermeulen
  • Fluorescent quenching detection reagents and methods
    Patent number: 7662942
    Abstract: Oligonucleotide probes containing two labels are provided and are useful in hybridization assays. The probes can also contain a minor groove binding group.
    Type: Grant
    Filed: January 23, 2006
    Date of Patent: February 16, 2010
    Assignee: Elitech Holdings, B.V.
    Inventors: Michael W. Reed, Eugeny Alexander Lukhtanov, Alexander A. Gall, Robert O. Dempcy, Nicolaas M. J. Vermeulen
  • SINGLE NUCLEOTIDE POLYMORPHISM ANALYSIS OF HIGHLY POLYMORPHIC TARGET SEQUENCES
    Publication number: 20090087922
    Abstract: Methods and probes are provided for the analysis of target sequences having two or more polymorphisms wherein one of the polymorphisms is to be distinguished and another polymorphism is to be masked.
    Type: Application
    Filed: January 28, 2008
    Publication date: April 2, 2009
    Applicant: Epoch Biosciences, Inc.
    Inventors: Yevgeniy Belousov, Robert O. Dempcy, Sergey G. Lokhov, Alexei Vorobiev
  • Real-time linear detection probes: sensitive 5'-minor groove binder-containing probes for PCR analysis
    Patent number: 7485442
    Abstract: Oligonucleotide probes/conjugates are provided along with method for their use in assays to monitor amplification wherein the signal produced does not rely on 5? nuclease digestion.
    Type: Grant
    Filed: June 19, 2006
    Date of Patent: February 3, 2009
    Assignee: Epoch Biosciences, Inc.
    Inventors: Irina A. Afonina, Yevgeniy S. Belousov, Robert O. Dempcy, Igor V. Kutyavin, Sergey G. Lokhov, Eugeny A. Lukhtanov
  • Tleveling compositions
    Patent number: 7368549
    Abstract: Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor groove binders and reporter groups.
    Type: Grant
    Filed: April 19, 2005
    Date of Patent: May 6, 2008
    Assignee: Epoch Biosciences, Inc.
    Inventors: Robert O. Dempcy, Alexander A Gall, Sergey G. Lokhov, Irina A. Afonina, Michael J. Singer, Igor V. Kutyavin, Nicolaas M. J. Vermeulen
  • Single nucleotide polymorphism analysis of highly polymorphic target sequences
    Patent number: 7348146
    Abstract: Methods and probes are provided for the analysis of target sequences having two or more polymorphisms wherein one of the polymorphisms is to be distinguished and another polymorphism is to be masked.
    Type: Grant
    Filed: September 29, 2004
    Date of Patent: March 25, 2008
    Assignee: Epoch Biosciences, Inc.
    Inventors: Yevgeniy Belousov, Robert O. Dempcy, Sergey G. Lokhov, Alexei Vorobiev
  • Hybridization-triggered fluorescent detection of nucleic acids
    Patent number: 7297495
    Abstract: Compositions and methods for fluorescent detection of nucleic acids are provided. The compositions can be detected by fluorescence when hybridized to a nucleic acid containing a target sequence, but are non-fluorescent in the non-hybridized state. Alternatively, the fluorescence properties of the compositions change in a detectable manner upon hybridization to a nucleic acid containing a target sequence. Methods for synthesis and methods of use of the compositions are also provided.
    Type: Grant
    Filed: October 3, 2005
    Date of Patent: November 20, 2007
    Assignee: Epoch Biosciences, Inc.
    Inventors: Robert O. Dempcy, Irina Aleksandrovna Afonina, Nicolaas M. J. Vermeulen
  • Real-time linear detection probes: sensitive 5?-minor groove binder-containing probes for PCR analysis
    Patent number: 7205105
    Abstract: Oligonucleotide probes/conjugates are provided along with method for their use in assays to monitor amplification wherein the signal produced does not rely on 5? nuclease digestion.
    Type: Grant
    Filed: June 6, 2002
    Date of Patent: April 17, 2007
    Assignee: Epoch Biosciences, Inc.
    Inventors: Irina A. Afonina, Yevgeniy S. Belousov, Robert O. Dempcy, Igor V. Kutyavin, Sergey G. Lokhov, Eugeny A. Lukhtanov
  • Modified oligonucleotides for mismatch discrimination
    Patent number: 7045610
    Abstract: Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor groove binders and reporter groups.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: May 16, 2006
    Assignee: Epoch Biosciences, Inc.
    Inventors: Robert O. Dempcy, Alexander A. Gall, Sergey G. Lokhov, Irina A. Afonina, Michael J. Singer, Igor V. Kutyavin, Nicolaas M. J. Vermeulen
  • Non-aggregating non-quenching oligomer comprising nucelotide analogs, method of synthesis and use thereof
    Patent number: 6972328
    Abstract: The invention provides compositions and methods for improved hybridization analysis utilizing DNA, RNA, PNA and chimeric oligomers in which one or more purine bases are substituted by a pyrazolo[5,4-d]pyrimidine or by a 7-deazapurine purine analogue. Reduced self-aggregation and reduced fluorescence quenching are obtained when the oligomers are used in various methods involving hybridization. Methods of synthesis, as well as novel synthetic precursors, are also provided.
    Type: Grant
    Filed: November 4, 2003
    Date of Patent: December 6, 2005
    Assignee: Epoch Biosciences, Inc.
    Inventors: Alexander A. Gall, Igor V. Kutyavin, Nicolaas M. J. Vermeulen, Robert O. Dempcy
  • Process for the synthesis of pyrazolopyrimidines
    Patent number: 6962991
    Abstract: The present invention provides a nucleoside comprising a pyrazolopyrimidine base and a process for producing the same. In particular, the processes of the present invention comprises using a halogenated pyrazolopyrimidine base and removing the halogen after the base is coupled to a sugar moiety. The presence of the halogen on the nucleoside base allows facile and economical production of a large quantity of nucleosides.
    Type: Grant
    Filed: September 12, 2001
    Date of Patent: November 8, 2005
    Assignee: Epoch Biosciences, Inc.
    Inventors: Robert O. Dempcy, A. David Adams, Michael W. Reed, Yevgeniy S. Belousov