Abstract: The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

Abstract: The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

Abstract: Sleep enhancement system for assistance, monitoring, informing, and improving sleep habits of a user. A utilized monitoring device gathers user's vital signs for transmission to a smart device while an environment sensor gathers information from the surroundings which is then sent to an environment transmitter. Signals from the smart device and environment transmitter are transmitted to a processor by wireless transmission such as by electromagnetic waves, radio waves, infrared, sound or by being reported by audio or visual transmission. Signals are stored for current or future commands to control the environment, smart devices, and appliances for a user. In addition to being able to control these, an input to the ABTT terminus, such as heat or cold, can be applied to encourage entry into sleep or wake from sleep, as well as release of supplements or drugs through a patch placed on the ABTT terminus or another bodily region.

Abstract: A valve has a body with multiple openings and a rotary valve member rotatable in a body cavity to control flow through the openings. A fixed closure member extends over one of the body openings, and a valve member control extends through the closure. A drain passage has a first portion in the fixed closure and a second portion in the rotary valve member. Those portions are brought into registration when the rotary member is in one position of flow control.

Abstract: A butterfly valve comprises:(a) a valve body having a generally cylindrical cavity defining a longitudinal axis, the body having first and second ports communicating with the cavity,(b) a rotary valve member in the cavity, and having a generally cylindrical exterior surface and a side opening therethrough generally normal to that axis,(c) the valve member having a butterfly closure that extends crosswise of the side opening,(d) the valve member having an open position in which the side opening is in alignment with such ports with the butterfly closure in edgewise flow passing alignment with the ports to pass fluid flow through the side opening, and the valve member having a close position in which the side opening is also in alignment with such ports but with the butterfly closure in flow blocking relation to the ports to block fluid flow through the side opening.

Abstract: A valve has a body with multiple openings and a rotary valve member rotatable in a body cavity to control flow through the openings. A fixed closure member extends over one of the body openings, and a valve member control extends through the closure. A drain passage has a first portion in the fixed closure and a second portion in the rotary valve member. Those portions are brought into registration when the rotary member is in one position of flow control.

Abstract: Liquid levels for controlled in systems that include different liquid bodies between which liquid circulates. Such bodies may typically include swimming pools and spas.

Abstract: A valve having a valve body, a valve cavity, a first opening and a second opening with a valve member rotatably positioned within the valve cavity. The valve member may have a generally cylindrical hollow configuration with an end opening in alignment with the first opening, and a side opening with the valve member positioned for rotation to bring the side opening into or out of alignment with the second opening. A seal means is supported by the valve member in slidable contact with the valve cavity with the seal means enclosing the end opening and side opening of the valve member.The valve body may also include a valve member opening in alignment with the valve member. A removable closure member is positioned over the valve member opening. On removal of the closure member, the valve member may be removed from the valve cavity by withdrawing the valve member through the valve member opening.

Abstract: A valve having a valve body, a valve cavity, a first opening and a second opening with a valve member rotatably positioned within the valve cavity. The valve member may have a generally cylindrical hollow configuration with an end opening in alignment with the first opening, and a side opening with the valve member positioned for rotation to bring the side opening into or out of alignment with the second opening. A seal means is supported by the valve member in slidable contact with the valve cavity with the seal means enclosing the end opening and side opening of the valve member.The valve body may also include a valve member opening in alignment with the valve member. A removable closure member is positioned over the valve member opening. On removal of the closure member, the valve member may be removed from the valve cavity by withdrawing the valve member through the valve member opening.