Abstract: A system analyzes data including healthcare orders initiating treatment or services used in patient healthcare. The system includes a data processor and a message processor. The data processor identifies a potential change in use of a particular treatment by examining data, representing multiple orders generated over a particular time period, used in treating multiple patients to identify a number of orders initiating application of a particular treatment to individual patients of the multiple patients to address a particular medical condition. The data processor also determines whether the number of orders exceeds a predetermined threshold and/or whether a rate of change in the number of orders relative to a previously determined number of orders is significant. The message processor initiates generation of a message to alert a message recipient of an identified potential change in use of the particular treatment.