Patents by Inventor Robert Parkhill
Robert Parkhill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10502730Abstract: A system and method provide for high through put determination of agglutination states. The system includes a rotating table and multiple plate tilting stations. The system also includes one or more optical paths positioned to image entire plate arrays in tilted and/or untitled configurations. The system preferably includes image analysis software to analyze an image of an array of test wells and determine an agglutination state of each well based on the image analysis.Type: GrantFiled: June 7, 2018Date of Patent: December 10, 2019Assignee: SANOFI PASTEUR VAXDESIGN CORPORATIONInventors: Michael Nguyen, Robert Parkhill
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Publication number: 20180292397Abstract: A system and method provide for high through put determination of agglutination states. The system includes a rotating table and multiple plate tilting stations. The system also includes one or more optical paths positioned to image entire plate arrays in tilted and/or untilted configurations. The system preferably includes image analysis software to analyze an image of an array of test wells and determine an agglutination state of each well based on the image analysis.Type: ApplicationFiled: June 7, 2018Publication date: October 11, 2018Applicant: Sanofi Pasteur VaxDesign CorporationInventors: Michael NGUYEN, Robert PARKHILL
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Patent number: 10012643Abstract: A system and method provide for high through put determination of agglutination states. The system includes a rotating table and multiple plate tilting stations. The system also includes one or more optical paths positioned to image entire plate arrays in tilted and/or untilted configurations. The system preferably includes image analysis software to analyze an image of an array of test wells and determine an agglutination state of each well based on the image analysis.Type: GrantFiled: July 28, 2015Date of Patent: July 3, 2018Assignee: SANOFI PASTEUR VAXDESIGN CORPORATIONInventors: Michael Nguyen, Robert Parkhill
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Patent number: 9625444Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.Type: GrantFiled: March 20, 2014Date of Patent: April 18, 2017Assignees: SANOFI PASTEUR VAXDESIGN CORPORATION, THE SCRIPPS RESEARCH INSTITUTE, MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH, MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITYInventors: William L Warren, Heather Fahlenkamp, Russell Higbee, Anatoly Kachurin, Conan Li, Mike Nguyen, Robert Parkhill, Guzman Sanchez-Schmitz, Darrell J. Irvine, Gwendalyn J. Randolph, Nir Hacohen, Bruce Torbett
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Publication number: 20160025727Abstract: A system and method provide for high through put determination of agglutination states. The system includes a rotating table and multiple plate tilting stations. The system also includes one or more optical paths positioned to image entire plate arrays in tilted and/or untilted configurations. The system preferably includes image analysis software to analyze an image of an array of test wells and determine an agglutination state of each well based on the image analysis.Type: ApplicationFiled: July 28, 2015Publication date: January 28, 2016Inventors: Michael Nguyen, Robert Parkhill
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Publication number: 20140273209Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.Type: ApplicationFiled: March 20, 2014Publication date: September 18, 2014Applicants: SANOFI PASTEUR VAXDESIGN CORPORATION, THE SCRIPPS RESEARCH INSTITUTE, MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY, THE WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH, MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: William L WARREN, Heather FAHLENKAMP, Russell HIGBEE, Anatoly KACHURIN, Conan LI, Mike NGUYEN, Robert PARKHILL, Guzman SANCHEZ-SCHMITZ, Darrell J. IRVINE, Gwendalyn J. RANDOLPH, Nir HACOHEN, Bruce TORBETT
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Patent number: 8722402Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.Type: GrantFiled: September 10, 2012Date of Patent: May 13, 2014Assignees: Sanofi Pasteur Vaxdesign Corporation, Mount Sinai School of Medicine, The Whitehead Institute, Massachusetts Institute of Technology, The Scripps Research InstituteInventors: William L Warren, Heather Fahlenkamp, Russell Higbee, Anatoly Kachurin, Conan Li, Mike Nguyen, Robert Parkhill, Guzman Sanchez-Schmitz, Darrell J. Irvine, Gwendalyn J. Randolph, Nir Harcohen, Bruce Torbett
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Publication number: 20130078656Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.Type: ApplicationFiled: September 10, 2012Publication date: March 28, 2013Applicants: SANOFI PASTEUR VAXDESIGN CORPORATION, THE WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH, MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE SCRIPPS RESEARCH INSTITUTEInventors: William L. WARREN, Heather FAHLENKAMP, Russell HIGBEE, Anatoly KACHURIN, Conan LI, Mike NGUYEN, Robert PARKHILL, Guzman SANCHEZ-SCHMITZ, Darrell J. IRVINE, Gwendalyn J. RANDOLPH, Nir HACOHEN, Bruce TORBETT
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Patent number: 8298823Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interactions with the immune system.Type: GrantFiled: March 24, 2010Date of Patent: October 30, 2012Assignee: Sanofi Pasteur Vaxdesign CorporationInventors: William L. Warren, Robert Parkhill, Michael N. Nguyen, Guzman Sanchez-Schmitz, Heather Fahlenkamp, Russell Higbee, Donald Drake, III, Anatoly Kachurin, David Moe
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Patent number: 8288159Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.Type: GrantFiled: March 17, 2010Date of Patent: October 16, 2012Assignee: Sanofi Pasteur Vaxdesign Corp. et al.Inventors: William L Warren, Heather Fahlenkamp, Russell Higbee, Anatoly Kachurin, Conan Li, Mike Nguyen, Robert Parkhill, Guzman Sanchez-Schmitz, Darrell J. Irvine, Gwendalyn J. Randolph, Nir Harcohen, Bruce Torbett
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Publication number: 20110171689Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.Type: ApplicationFiled: March 17, 2010Publication date: July 14, 2011Applicant: VAXDESIGN CORPORATIONInventors: William L. Warren, Heather Fahlenkamp, Russell Higbee, Anatoly Kachurin, Conan Li, Mike Nguyen, Robert Parkhill, Guzman Sanchez-Schmitz, Darrell J. Irvine, Gwendalyn J. Randolph, Nir Hacohen, Bruce Torbett
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Patent number: 7855074Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.Type: GrantFiled: April 28, 2005Date of Patent: December 21, 2010Assignee: VaxDesign Corp.Inventors: William L. Warren, Heather Fahlenkamp, Russell Higbee, Anatoly Kachurin, Conan Li, Mike Nguyen, Robert Parkhill, Guzman Sanchez-Schmitz, Darrell J. Irvine, Gwendalyn J. Randolph, Nir Hacohen, Bruce Torbett
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Patent number: 7785883Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interactions with the immune system.Type: GrantFiled: March 15, 2006Date of Patent: August 31, 2010Assignee: Vax Design Corp.Inventors: William L. Warren, Robert Parkhill, Michael N. Nguyen, Guzman Sanchez-Schmitz, Heather Fahlenkamp, Russell Higbee, Donald Drake, III, Anatoly Kachurin, David Moe
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Publication number: 20100178676Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interactions with the immune system.Type: ApplicationFiled: March 24, 2010Publication date: July 15, 2010Applicant: VAXDESIGN CORP.Inventors: William L. WARREN, Robert PARKHILL, Michael N. NGUYEN, Guzman SANCHEZ-SCHMITZ, Heather FAHLENKAMP, Russell HIGBEE, Donald DRAKE, III, Anatoly KACHURIN, David MOE
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Publication number: 20100105135Abstract: Dendritic cells (DCs) for research and clinical applications are typically derived from purified blood monocytes that are cultured in a cocktail of cytokines for a week or more. Because it has been suggested that these cytokine-derived DCs may be deficient in some important immunological functions and might not accurately represent antigen-presenting cell (APC) populations found under physiologic conditions, there is a need for methods that allow the generation of DCs in a more physiologically relevant manner. The present invention comprises a simple and reliable technique for generating large numbers of highly purified DCs, based on a single migration of blood monocytes through endothelial cells that are cultured in, for example, a Transwell® device.Type: ApplicationFiled: October 30, 2009Publication date: April 29, 2010Applicant: VaxDesign Corp.Inventors: Donald DRAKE, III, David MOE, Conan LI, Heather FAHLENKAMP, Guzman SANCHEZ-SCHMITZ, Russell HIGBEE, Robert PARKHILL, William L. WARREN
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Publication number: 20080111282Abstract: The present invention is a method of freeform fabrication of three-dimensional (3D) objects by depositing polymer colloidal particle based building materials in a predetermined pattern, preferably for biological and/or medical applications. The process of the present invention includes formulating a polymer colloidal dispersion for use as a building material; delivering the dispersion material to a solid freeform fabrication system, and depositing the extruded filaments in a predetermined pattern to form a three-dimensional (3D) object.Type: ApplicationFiled: November 10, 2006Publication date: May 15, 2008Inventors: Baojun Xie, Jim Smay, William Warren, Robert Parkhill
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Publication number: 20070178076Abstract: Dendritic cells (DCs) for research and clinical applications are typically derived from purified blood monocytes that are cultured in a cocktail of cytokines for a week or more. Because it has been suggested that these cytokine-derived DCs may be deficient in some important immunological functions and might not accurately represent antigen-presenting cell (APC) populations found under physiologic conditions, there is a need for methods that allow the generation of DCs in a more physiologically relevant manner. The present invention comprises a simple and reliable technique for generating large numbers of highly purified DCs, based on a single migration of blood monocytes through endothelial cells that are cultured in, for example, a Transwell® device.Type: ApplicationFiled: December 21, 2006Publication date: August 2, 2007Inventors: Donald Drake, David Moe, Conan Li, Heather Fahlenkamp, Guzman Sanchez-Schmitz, Russell Higbee, Robert Parkhill, William Warren
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Publication number: 20070141552Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interactions with the immune system.Type: ApplicationFiled: November 8, 2006Publication date: June 21, 2007Inventors: William Warren, Robert Parkhill, Michael Nguyen, Guzman Sanchez-Schmitz, Heather Fahlenkamp, Russell Higbee, Donald Drake, Anatoly Kachurin, David Moe
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Publication number: 20060270029Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interactions with the immune system.Type: ApplicationFiled: March 15, 2006Publication date: November 30, 2006Inventors: William Warren, Robert Parkhill, Michael Nguyen, Guzman Sanchez-Schmitz, Heather Fahlenkamp, Russell Higbee, Donald Drake, Anatoly Kachurin, David Moe
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Publication number: 20050282148Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.Type: ApplicationFiled: April 28, 2005Publication date: December 22, 2005Inventors: William Warren, Heather Fahlenkamp, Russell Higbee, Anatoly Kachurin, Conan Li, Mike Nguyen, Robert Parkhill, Guzman Sanchez-Schmitz, Darrell Irvine, Gwendalyn Randolph, Nir Hacohen, Bruce Torbett