Abstract: The present invention relates to the development of and use of genetically modified human differentiated cells coupled with xenotransplantation into animal models to identify injury and disease-specific RNA and/or protein biomarkers. Specifically, the present invention encompasses two complementary methods for biomarker discovery that enable the direct and selective labelling, isolation, and analysis of human-specific RNA and/or proteins from xenotransplantation (or chimeric) animal models. Both methods involve the treatment of animal models with an RNA analog and/or amino acid analog that enables the specific isolation and quantification of human RNAs and/or proteins for the identification of novel human biomarkers for a large array of human injuries and diseases.

Abstract: A rotary metering valve arrangement comprises a rotary metering valve arranged to control the supply of fuel to a Pressure Raising and Shut-Off Valve (PRSOV), the metering valve comprising a valve plate provided with first and second latching ports and an angularly movable valve element provided with a recess registrable, in use, with the first and second latching ports to control communication therebetween, the PRSOV comprising a valve member slidable within a bore provided with third and fourth latching ports the valve member being provided with a recess registrable, in use, with the third and fourth latching ports to control communication therebetween, the second and third latching ports communicating with one another.

Abstract: A rotary metering valve arrangement comprises a rotary metering valve arranged to control the supply of fuel to a Pressure Raising and Shut-Off Valve (PRSOV), the metering valve comprising a valve plate provided with first and second latching ports and an angularly movable valve element provided with a recess registrable, in use, with the first and second latching ports to control communication therebetween, the PRSOV comprising a valve member slidable within a bore provided with third and fourth latching ports the valve member being provided with a recess registrable, in use, with the third and fourth latching ports to control communication therebetween, the second and third latching ports communicating with one another.