Abstract: Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.

Abstract: The disclosure is directed at a system and method of automated object launching, for replicating ball trajectories, for example with a baseball. The system receives an input from a user that includes trajectory information and then launches an object based on that trajectory. The system includes subsystems that control the orientation of the object to be launched and the position of the system itself. The system also includes a results tracking database to provide analytics and the like for the user.

Abstract: The invention relates the use of Human Epidermal Growth Factor Receptor 2 (HER2) gene copy number and HER2 mRNA levels as biomarkers to identify cancers which will respond to treatment with a specific binding member comprising a HER2 antigen binding site engineered into a structural loop region of a constant domain, e.g. CH3 domain, of the specific binding member, and specific binding members which compete with such a binding member for binding to HER2.

Abstract: A rapid deployment assembly 10 which may be placed upon a selectively movable assembly 18, such as by way of example and without limitation, a pickup type truck, or other selectively movable assembly and which allows for rapid ingress and egress into and out of the assembly 18 and such ingress and egress is achieved by the selectively deployment of various members 12, 14, 16 which selectively form steps and which may later cooperatively form a tailgate assembly.

Abstract: Provided is a composition comprising fatty acid bis-amide, inorganic particulate such as pumice, cellulosic particulate, thermoplastic and maleic anhydride grafted polyolefin. The combination of an ethylene bis-amide and a minor amount of pumice produces cellulosic-thermoplastic composite that has superior extrusion properties over conventional metal stearate/ethylene bis-stearamide (EBS) compositions such as improved flex strength and resistance to water absorption.

Abstract: Fuels, especially hydrocarbon fuels, and lubricants, especially lubricating oils, contain dithiocarbamyl ?-hydroxy fatty acid esters, a class of anti-corrosion, anti-wear, anti-fatigue, and extreme pressure additives that are derived from epoxidized fatty acid esters. The additives exhibit synergistic anti-wear activity in combination with phosphorus containing additives.

Abstract: Fuels, especially hydrocarbon fuels, and lubricants, especially lubricating oils, contain a class of anti-corrosion, anti-fatigue, and anti-wear additives that are derived epoxidized esters of fatty acids. Epoxidized 2-ethylhexyl tallate is particularly effective.

Abstract: Fuels, especially hydrocarbon fuels, and lubricants, especially lubricating oils, contain a class of anti-corrosion, anti-wear, anti-fatigue, and extreme pressure additives that are derived from 1,3-dithiolane-2-thiones.

Abstract: Disclosed herein is a composition comprising: (A) a lubricant or a hydrocarbon fuel; (B) at least one hydroxy carboxylic acid ester or hydroxy polycarboxylic acid ester having the generic formula defined herein; and (C) at least one phosphorus-containing additive.

Abstract: A method for preventing and/or treating infection includes transitioning the temperature in a suspected area of infection based on an assessment of the existence and/or likelihood of infection in a localized area. Also, an apparatus for transitioning the temperature in a suspected area of infection, which includes a heat transfer element for transferring thermal energy to or from the suspected area of infection, and a thermal energy source for supplying thermal energy to the heat transfer element. The apparatus may also include one or more positioning elements and one or more temperature detecting elements. Activation of the apparatus may be manual or automated, and may rely on a feedback loop, or interaction with one or more external devices.

Abstract: A composition is disclosed that comprises: (A) a lubricant, and (B) at least one compound selected from the group consisting of alcohols of the formulae: wherein Y is N, O, or S; R1, R2, R3, and R4 are independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkenyl, alkaryl, aryl, alkoxy, and alkyl ester; R5 is selected from the group consisting of hydrogen, alkyl, alkoxy, a carboxy alkyl group of the structure: (CH2)pCO2R9 where: p is from 1 to 18, and R9 is hydrocarbyl; R7 is selected from the group consisting of hydrogen, CH2OR11, alkyl, and alkenyl, wherein: said alkyl and alkenyl groups are optionally substituted with OH, oxirane, or X; R11 is selected from the group consisting of alkyl of from 1 to 36 carbon atoms, alkaryl of from 6 to about 50 carbon atoms, and aryl, and may contain ether or ester functionalities; X is of the structure: or R5 and R7 are fused together to form a ring of 3-10, preferably 5 or 6, carbon atoms, which may be further substituted wit

Abstract: A transaction printer includes the MICR encoding of indicia at a precise location called the amount field. In order to accomplish this, an optical sensor is provided in a check processing machine at a point-of-sale to detect the edge of the check and stage it at a known location from the thermal, MICR print head. A clutch mechanism is used to engage the print head with a platen and to engage a read head with the check, so that indicia can be sequentially imprinted and read within the check processing machine in a single, sequential operation that moves the check from a home position to a MICR print position, and subsequently to a MICR read position.

Abstract: This insecticidal cable has a pair or pairs of exposed electrical conductive wire for use in a fly control apparatus. An electronic control unit provides pulsed high voltage between the parallel exposed conductive wires. Insects which contact either one or both of the pair of conductive wires are killed by destruction of the insect nervous system. The cable both supports the conductive wires and holds them with the correct separation. The apparatus is used to destroy flies in stables, poultry houses, and other structures.

Abstract: A process and apparatus for loosening adhesive from a drum and abrading labels, paint, and adhesive from the drum with high speed brushes. The drums are heated with an open flame to loosen the adhesive before the labels, paint, and adhesive are abraded from the drums with the brushes. A "soft-touch" pneumatic controller is connected to the brushes to maintain optimum contact of the brushes with the drum and to prevent premature wearing of the brushes. The drum is moved horizontally relative to the brushes during the brushing process to prevent stripes of paint being left on the drum by the brushes.