Patents by Inventor Robert S. Hodges
Robert S. Hodges has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20030211114Abstract: A C-terminal pilin peptide vaccine for immunizing or treating a patient for infection by a Pseudomonas aeruginosa (PA) infection is disclosed. The peptide comprises the peptide identified as SEQ ID NOS. 3-6; and a carrier protein conjugated to the peptide. Also disclosed is a pilin peptide C-terminal PA pilin peptide having the amino acid sequence identified as SEQ ID NO: 3, and analogs thereof having one of residues T, K, or A at position 130, D, T, or N at position 132, Q, A, or V at position 133, E, P, N, or A at position 135, Q, M, or K at position 136, and I, T, L, or R at position 138, excluding SEQ ID NOS: 1, 2, 9, 10, and 11, and the ability to cross-react with antibodies against the corresponding C-terminal peptides from PA strains PAK and PAO.Type: ApplicationFiled: January 14, 2003Publication date: November 13, 2003Inventors: Robert S. Hodges, Randall T. Irvin, Paul J. Cachia
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Patent number: 6541007Abstract: A C-terminal pilin peptide vaccine for immunizing or treating a patient for infection by a Pseudomonas aeruginosa (PA) infection is disclosed. The peptide comprises the peptide identified as SEQ ID NOS. 3-6; and a carrier protein conjugated to the peptide. Also disclosed is a pilin peptide C-terminal PA pilin peptide having the amino acid sequence identified as SEQ ID NO:3, and analogs thereof having one of residues T, K, or A at position 130, D, T, or N at position 132, Q, A, or V at position 133, E, P, N, or A at position 135, Q, M, or K at position 136, and I, T, L, or R at position 138, excluding SEQ ID NOS: 1, 2, 9, 10, and 11, and the ability to cross-react with antibodies against the corresponding C-terminal peptides from PA strains PAK and PAO.Type: GrantFiled: June 30, 1999Date of Patent: April 1, 2003Assignee: The Governors of the University of AlbertaInventors: Robert S. Hodges, Randall T. Irvin, Paul J. Cachia
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Patent number: 6478939Abstract: A biosensor apparatus for detecting a binding event between a ligand and receptor. The apparatus includes a biosensor surface and surface-bound two-subunit heterodimer complexes composed of first and second, preferably oppositely charged peptides that together form an &agr;-helical coiled-coil heterodimer. The first peptide is attached to the biosensor surface, and the second peptide carries the ligand, accessible for binding by a ligand-binding agent. Binding of anti-ligand binding agent to the surface-bound ligand is detected by a suitable detector. A ligand-specific biosensor surface can be readily prepared from a universal template containing the first charged peptide, by addition of a selected ligand attached to the second peptide.Type: GrantFiled: May 24, 2000Date of Patent: November 12, 2002Assignees: Pence, Inc., McGill UniversityInventors: R. Bruce Lennox, Robert S. Hodges, Randall T. Irvin
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Patent number: 6461490Abstract: A biosensor apparatus for detecting a binding event between a ligand and receptor. The apparatus includes a biosensor surface and surface-bound two-subunit heterodimer complexes composed of first and second, preferably oppositely charged peptides that together form an &agr;-helical coiled-coil heterodimer. The-first peptide is attached to the biosensor surface, and the second peptide carries the ligand, accessible for binding by a ligand-binding agent. Binding of anti-ligand binding agent to the surface-bound ligand is detected by a suitable detector. A ligand-specific biosensor surface can be readily prepared from a universal template containing the first charged peptide, by addition of a selected ligand attached to the second peptide.Type: GrantFiled: July 27, 2000Date of Patent: October 8, 2002Assignees: PENCE, Inc., McGill UniversityInventors: R. Bruce Lennox, Robert S. Hodges, Randall T. Irvin
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Patent number: 6358921Abstract: The invention concerns antimicrobial cyclic peptides and peptide analogs having relatively low hemolytic activity. Peptides of the invention are effective in killing and/or inhibiting growth of a number of microorganisms, including gram-positive bacteria, gram-negative bacteria, fungi and mycoplasma. Also disclosed are methods for inhibiting or killing such microorganisms, and therapeutic preparations for such inhibiting or killing.Type: GrantFiled: October 10, 1997Date of Patent: March 19, 2002Assignee: Pence, Inc.Inventors: Leslie H. Kondejewski, Robert S. Hodges, David S. Wishart, Robert E. W. Hancock, Ronald N. McElhaney, Elmar J. Prenner, Ruthven N. A. H. Lewis
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Patent number: 6165335Abstract: A biosensor apparatus for detecting a binding event between a ligand and receptor. The apparatus includes a biosensor surface and surface-bound two-subunit heterodimer complexes composed of first and second, preferably oppositely charged peptides that together form an .alpha.-helical coiled-coil heterodimer. The first peptide is attached to the biosensor surface, and the second peptide carries the ligand, accessible for binding by a ligand-binding agent. Binding of anti-ligand binding agent to the surface-bound ligand is detected by a suitable detector. A ligand-specific biosensor surface can be readily prepared from a universal template containing the first charged peptide, by addition of a selected ligand attached to the second peptide.Type: GrantFiled: April 24, 1997Date of Patent: December 26, 2000Assignee: Pence and McGill UniversityInventors: R. Bruce Lennox, Robert S. Hodges, Randall T. Irvin
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Patent number: 6130037Abstract: A biosensor apparatus for detecting a binding event between a ligand and receptor. The apparatus includes an electrode substrate coated with a high-dielectric hydrocarbon-chain monolayer, and having ligands attached to the exposed monolayer surface. Binding of a receptor to the monolayer-bound ligand, and the resultant perturbation of the monolayer structure, causes ion-mediated electron flow across the monolayer. In one embodiment, the monolayers have a coil-coil heterodimer embedded therein, one subunit of which is attached to the substrate, and the second of which carries the ligand at the monolayer surface.Type: GrantFiled: April 24, 1997Date of Patent: October 10, 2000Assignee: PENCE and McGill UniversityInventors: R. Bruce Lennox, Robert S. Hodges, Randall T. Irvin
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Patent number: 5955379Abstract: A biosensor apparatus for detecting a binding event between a ligand and receptor. The apparatus includes an electrode substrate coated with a high-dielectric hydrocarbon-chain monolayer, and having ligands attached to the exposed monolayer surface. Binding of a receptor to the monolayer-bound ligand, and the resultant perturbation of the monolayer structure, causes ion-mediated electron flow across the monolayer. In one embodiment, the monolayers have a coil--coil heterodimer embedded therein, one subunit of which is attached to the substrate, and the second of which carries the ligand at the monolayer surface.Type: GrantFiled: April 24, 1997Date of Patent: September 21, 1999Assignees: McGill University, PenceInventors: R. Bruce Lennox, Robert S. Hodges, Randall T. Irvin, Glen Armstrong, David R. Bundle, Pavel Kitov, Craig Railton
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Patent number: 5824483Abstract: Combinatorial libraries of different-sequence peptide members is disclosed. The libraries are comprised of stabilized, alpha-helical polypeptides having a similar tertiary structure but different amino acid residues at specific, "variable" positions in the sequence. The polypeptides are stabilized through coiled-coil interactions with other .alpha.-helical polypeptides and/or via intrahelical lactam bridges. Also disclosed are methods for using such libraries to screen for selected macromolecular ligands.Type: GrantFiled: June 16, 1995Date of Patent: October 20, 1998Assignee: Pence Inc.Inventors: Michael E. Houston, Jr., Robert S. Hodges
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Patent number: 5738996Abstract: A combinatorial library composition and method for using the library to construct oligomers effective to bind to a selected ligand is disclosed. The library composition includes at least two sets of ar oligomer libraries, each library set having selected oligomer subunit positions filled by known subunits, and other subunit positions containing permutations of subunits. In the selection method, oligomers from each library set are identified, and a new permutation library formed of subunits corresponding to the highest binding affinity oligomers in each library is screened for binding affinity to the selected ligand.Type: GrantFiled: June 15, 1994Date of Patent: April 14, 1998Assignee: Pence, Inc.Inventors: Robert S. Hodges, Randall T. Irvin, Arne Holm, Wah Y. Wong, Hasmukh B. Sheth, Devon L. Husband
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Patent number: 5641760Abstract: A method of treating Candida albicans infection is disclosed. In one embodiment, for treatment of oral or vaginal infection, the treatment is by topical application of a composition of conjugates that are each composed of a carrier structure and multiple .beta.GalNac(1-4).beta.Gal moieties attached to the structure. In another embodiment, for treatment of systemic infection, the treatment is by parenteral administration of a humanized form of a mouse monoclonal antibody produced by mouse hybridoma cell line Fm16 or cell line PK99H.Type: GrantFiled: June 17, 1994Date of Patent: June 24, 1997Assignee: Pence, Inc.Inventors: Lei Yu, Kok Kheong Lee, Hasmukh B. Sheth, Randall T. Irvin, Robert S. Hodges
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Patent number: 5612036Abstract: Treatment and diagnosis of P. aeruginosa infection or colonization is achieved in accordance with this invention by the discovery of a polypeptide which is smaller than the naturally occurring P. aeruginosa pillin protein. The pure polypeptide comprises at least one amino acid residue sequence containing about twelve amino acid residues and up to about twenty amino acid residues that define a sequence capable of immunologically mimicking an antigenic determinant cite of P. aeruginosa pilin. This amino acid residue sequence can repeat as a unit one or more times in the same polypeptide molecule. More than one of such repeating units and more than one repeating unit of the same type can be present in a single polypeptide molecule. The polypeptides act an antigens or immunogens and antibodies may be raised to the immunogens and a vaccine prepared suitable for the prevention of P. aeruginosa infection.Type: GrantFiled: August 25, 1995Date of Patent: March 18, 1997Assignee: The Governors of the University of AlbertaInventors: Robert S. Hodges, William Paranchych, Kok K. Lee, Sastry A. Parimi, Randall T. Irvin, Peter C. Doig
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Patent number: 5494672Abstract: A peptide having a sequence corresponding to a C-terminal portion of the Pseudomonas aeruginosa pilin protein is disclosed. The peptide is cross-reactive with surface peptides present in certain bacterial and fungal microorganisms, and is effective in inhibiting binding of such organisms to target epithelial cells. The peptide may also be employed in a vaccine composition, for producing immunity against such cross-reactive microorganisms. Also disclosed are methods of preparing peptides which are cross-reactive with the P. aeruginosa pilin peptide, and chimeric monoclonal antibodies immunoreactive with the pilin peptide.Type: GrantFiled: January 4, 1991Date of Patent: February 27, 1996Assignee: S.P.I. Synthetic Peptides IncorporatedInventors: Robert S. Hodges, William Paranchych, Randall T. Irvin, Kok K. Lee, Sastry A. Parimi, Dick E. Zoutman, Peter C. Doig, Wah Y. Wong
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Patent number: 5468484Abstract: The invention described includes methods and compositions useful in preventing infection by Pseudomonas aeruginosa and related organisms. Diclosed is a peptide having the sequence corresponding to an antigenic site in the protein exoenzyme S which is antigenically similar to a C-terminal portion of the Pseudomonas aeruginosa pilin protein. The peptide is cross-reactive with surface peptides present in certain bacterial and fungal microorganisms, and is effective in inhibiting binding of such organisms to target epithelial cells. The peptide may also be employed in a vaccine composition, for producing immunity against Pseudomonas aeruginosa as well as against such cross-reactive microorganisms.Type: GrantFiled: June 28, 1993Date of Patent: November 21, 1995Assignee: S.P.I. Synthetic Peptides IncorporatedInventors: Robert S. Hodges, Randall T. Irvin, William Paranchych, Pamela A. Sokol, Donald E. Woods
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Patent number: 5445818Abstract: Treatment and diagnosis of P. aeruginosa infection or colonization is achieved in accordance with this invention by the discovery of a polypeptide which is smaller than the naturally occurring P. aeruginosa pillin protein. The pure polypeptide comprises at least one amino acid residue sequence containing about twelve amino acid residues and up to about twenty amino acid residues that define a sequence capable of immunologically mimicking an antigenic determinant cite of P. aeruginosa pilin. This amino acid residue sequence can repeat as a unit one or more times in the same polypeptide molecule. More than one of such repeating units and more than one repeating unit of the same type can be present in a single polypeptide molecule. The polypeptides act an antigens or immunogens and antibodies may be raised to the immunogens and a vaccine prepared suitable for the prevention of P. aeruginosa infection.Type: GrantFiled: August 10, 1992Date of Patent: August 29, 1995Assignee: The Governors of the University of AlbertaInventors: Robert S. Hodges, William Paranchych, Kok K. Lee, Sastry A. Parimi, Randall T. Irvin, Peter C. Doig
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Patent number: 5223604Abstract: A peptide having a sequence corresponding to an antigenic site in the protein exoenzyme S which is antigenically similar to a C-terminal portion of the Pseusdomonas aeruginosa pilin protein is disclosed. The peptide is cross-reactive with surface peptides present in certain bacterial and fungal microorganisms, and is effective in inhibiting binding of such organisms to target epithelial cells. The peptide may also be employed in a vaccine composition, for producing immunity against such cross-reactive microorganisms.Type: GrantFiled: June 25, 1991Date of Patent: June 29, 1993Assignee: S.P.I. Synthetic Peptides IncorporatedInventors: Robert S. Hodges, Randall T. Irvin, William Paranchych, Pamela A. Sokol, Donald E. Woods