Patents by Inventor Robert S. Kowalski

Robert S. Kowalski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240158807
    Abstract: Circular RNA and methods and constructs for engineering circular RNA are disclosed. In some embodiments, the circular RNA includes the following elements arranged in the following sequence: a) a 3? Group I self-splicing intron fragment, b) an internal ribosome entry site (IRES), c) a protein coding region or noncoding region, and d) a 5? Group I self-splicing intron fragment.
    Type: Application
    Filed: December 18, 2023
    Publication date: May 16, 2024
    Inventors: Daniel G. Anderson, Robert Alexander Wesselhoeft, Piotr S. Kowalski
  • Patent number: 11981909
    Abstract: Disclosed are methods and constructs for engineering circular RNA Disclosed is a vector for making circular RNA, said vector comprising the following elements operably connected to each other and arranged in the following sequence: a) a 5? homology arm, b) a 3? group I intron fragment containing a 3? splice site dinucleotide, c) an optional 5? spacer sequence, d) a protein coding or noncoding region, e) an optional 3? spacer sequence, f) a 5? Group I intron fragment containing a 5? splice site dinucleotide, and g) a 3? homology arm. This vector allows production of a circular RNA that is translatable or biologically active inside eukaryotic cells. In one embodiment, the vector can comprise the 5? spacer sequence, but not the 3? spacer sequence. In yet another embodiment, the vector can also comprise the 3? spacer sequence, but not the 5? spacer sequence.
    Type: Grant
    Filed: June 5, 2019
    Date of Patent: May 14, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Daniel G. Anderson, Robert Alexander Wesselhoeft, Piotr S. Kowalski
  • Patent number: 7192289
    Abstract: A module system for power distribution includes sealed modules for providing control or access to the power, wherein the module system allows interconnection to a modular circuit breaker panel for monitoring power consumption and optimizing use for a given circuit.
    Type: Grant
    Filed: March 10, 2004
    Date of Patent: March 20, 2007
    Inventor: Robert S. Kowalski