Abstract: Tablets, capsules, sachets, or papers having one or more aliphatic amine polymers allow for the targeted release of the polymers at a specific region of the gastrointestinal tract, especially the small intestine. These tablets, capsules, sachets, or papers are useful in a method for lowering cholesterol in a mammal in need thereof. The tablet includes a tablet core having an aliphatic amine polymer, and an enteric coating for the core. The capsule, sachet or paper includes a plurality of beads where the beads have a bead core having an aliphatic amine polymer, an enteric coating therefor and optionally a water-soluble coating.