Patents by Inventor Robert Savel
Robert Savel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11918653Abstract: Disclosed herein are triglyceride based formulations, compositions, and methods for the treatment of otic diseases and conditions. Such triglyceride based formulations and compositions are derived from long-chain triglycerides and allow for the delivery of a variety of therapeutic agents to the outer, middle, and/or inner ear.Type: GrantFiled: December 21, 2018Date of Patent: March 5, 2024Assignee: DOMPÉ FARMACEUTICI S.P.A.Inventors: Robert Savel, Zhanpeng Zhang, Scott Coleman, Fabrice Piu, Hong Qi, Martha Pastuszka
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Publication number: 20230190642Abstract: Disclosed herein are otic formulations and compositions comprising growth factors. These otic formulations and compositions allow for the delivery of the growth factor to the outer, middle, and/or inner ear for the treatment of otic diseases and disorders.Type: ApplicationFiled: January 9, 2019Publication date: June 22, 2023Inventors: Fabrive PIU, Bonnie JACQUES, Natalia TSIVKOVSKAIA, Hong QI, Robert SAVEL, Scott COLEMAN, Zhanpeng ZHANG, Martha PASTUSZKA
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Publication number: 20220233522Abstract: Disclosed herein are otic product kits for administration of a sterilized formulation. In some embodiments, the otic product kit comprises: an aseptic container containing the sterilized formulation; a syringe; and an administration needle connectable to the syringe, wherein the sterilized formulation comprising: from about 5.5 wt % to about 6.5 wt % multiparticulate ciprofloxacin; from about 15 wt % to about 17 wt % poloxamer 407; and water. Also disclosed herein are methods of preparing and administrating the sterilized formulation. In some embodiments, the method comprising (1) transferring the sterilized otic formulation from an aseptic container to a syringe through a preparation needle; (2) replacing the preparation needle with an administration needle; and (3) injecting the sterilized otic formulation from the syringe through the administration needle into the ear of a patient.Type: ApplicationFiled: December 29, 2021Publication date: July 28, 2022Inventors: Scott H. COLEMAN, Wei-Cheng LIAW, Jerry WROBLEWSKI, Robert SAVEL
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Patent number: 11246863Abstract: Disclosed herein are otic product kits for administration of a sterilized formulation. In some embodiments, the otic product kit comprises: an aseptic container containing the sterilized formulation; a syringe; and an administration needle connectable to the syringe, wherein the sterilized formulation comprising: from about 5.5 wt % to about 6.5 wt % multiparticulate ciprofloxacin; from about 15 wt % to about 17 wt % poloxamer 407; and water. Also disclosed herein are methods of preparing and administrating the sterilized formulation. In some embodiments, the method comprising (1) transferring the sterilized otic formulation from an aseptic container to a syringe through a preparation needle; (2) replacing the preparation needle with an administration needle; and (3) injecting the sterilized otic formulation from the syringe through the administration needle into the ear of a patient.Type: GrantFiled: December 9, 2016Date of Patent: February 15, 2022Assignee: ALK-ABELLÓ, INC.Inventors: Scott H. Coleman, Wei-Cheng Liaw, Jerry Wroblewski, Robert Savel
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Publication number: 20210138069Abstract: Disclosed herein are triglyceride based formulations, compositions, and methods for the treatment of otic diseases and conditions. Such triglyceride based formulations and compositions are derived from long-chain triglycerides and allow for the delivery of a variety of therapeutic agents to the outer, middle, and/or inner ear.Type: ApplicationFiled: December 21, 2018Publication date: May 13, 2021Inventors: Robert SAVEL, Zhanpeng ZHANG, Scott COLEMAN, Fabrice PIU, Hong QI, Martha PASTUSZKA
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Publication number: 20200397907Abstract: Disclosed herein are triglyceride based formulations, compositions, and methods for the treatment of otic diseases and conditions. Such triglyceride based formulations and compositions are derived from medium chain triglycerides and allow for the delivery of a variety of therapeutic agents to the outer, middle, and/or inner ear.Type: ApplicationFiled: September 3, 2020Publication date: December 24, 2020Inventors: Robert SAVEL, Zhanpeng ZHANG, Scott COLEMAN, Fabrice PIU, Hong QI
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Patent number: 10821185Abstract: Disclosed herein are triglyceride based formulations, compositions, and methods for the treatment of otic diseases and conditions. Such triglyceride based formulations and compositions are derived from medium chain triglycerides and allow for the delivery of a variety of therapeutic agents to the outer, middle, and/or inner ear.Type: GrantFiled: June 29, 2017Date of Patent: November 3, 2020Assignee: Otonomy Inc.Inventors: Robert Savel, Zhanpeng Zhang, Scott Coleman, Fabrice Piu, Hong Qi
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Publication number: 20190000839Abstract: Disclosed herein are otic product kits for administration of a sterilized formulation. In some embodiments, the otic product kit comprises: an aseptic container containing the sterilized formulation; a syring; and an administration needle connectable to the syringe, wherein the sterilized formulation comprising: from about 5.5 wt % to about 6.5 wt % multiparticulate ciprofloxacin; from about 15 wt % to about 17 wt % poloxamer 407; and water. Also disclosed herein are methods of preparing and administrating the sterilized formulation. In some embodiments, the method comprising (1) transferring the sterilized otic formulation from an aseptic container to a syringe through a preparation needle; (2) replacing the preparation needle with an administration needle; and (3) injecting the sterilized otic formulation from the syringe through the administration needle into the ear of a patient.Type: ApplicationFiled: December 9, 2016Publication date: January 3, 2019Applicant: OTONOMY, INC.Inventors: Scott H. COLEMAN, Wei-Cheng LIAW, Jerry WROBLEWSKI, Robert SAVEL
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Publication number: 20180000950Abstract: Disclosed herein are triglyceride based formulations, compositions, and methods for the treatment of otic diseases and conditions. Such triglyceride based formulations and compositions are derived from medium chain triglycerides and allow for the delivery of a variety of therapeutic agents to the outer, middle, and/or inner ear.Type: ApplicationFiled: June 29, 2017Publication date: January 4, 2018Inventors: Robert Savel, Zhanpeng Zhang, Scott Coleman, Fabrice Piu, Hong Qi
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Patent number: 9757484Abstract: Disclosed herein are methods of making sterilized ciprofloxacin compositions. In some embodiments, the method includes the steps of: (a) forming an aqueous suspension comprising ciprofloxacin particles; (b) heating the aqueous suspension comprising ciprofloxacin particles at a temperature range of from about 100° C. to about 120° C.; and (c) allowing the aqueous suspension comprising ciprofloxacin particles to cool down. Also described herein are otic formulations containing ciprofloxacin formed by the disclosed methods, and therapeutic use of such otic formulation for providing sustained release of ciprofloxacin into the ear for treating various otic disorders and conditions.Type: GrantFiled: October 30, 2015Date of Patent: September 12, 2017Assignee: OTONOMY, INC.Inventors: Scott H. Coleman, Wei-Cheng Liaw, Jerry Wroblewski, Robert Savel
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Publication number: 20160279274Abstract: Disclosed herein are methods of making sterilized ciprofloxacin compositions. In some embodiments, the method includes the steps of: (a) forming an aqueous suspension comprising ciprofloxacin particles; (b) heating the aqueous suspension comprising ciprofloxacin particles at a temperature range of from about 100° C. to about 120° C.; and (c) allowing the aqueous suspension comprising ciprofloxacin particles to cool down. Also described herein are otic formulations containing ciprofloxacin formed by the disclosed methods, and therapeutic use of such otic formulation for providing sustained release of ciprofloxacin into the ear for treating various otic disorders and conditions.Type: ApplicationFiled: October 30, 2015Publication date: September 29, 2016Inventors: Scott H. Coleman, Wei-Cheng Liaw, Jerry Wroblewski, Robert Savel
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Publication number: 20160000948Abstract: Disclosed herein are methods of making sterilized ciprofloxacin compositions. In some embodiments, the method includes the steps of: (a) forming an aqueous suspension comprising ciprofloxacin particles; (b) heating the aqueous suspension comprising ciprofloxacin particles at a temperature range of from about 100° C. to about 120° C.; and (c) allowing the aqueous suspension comprising ciprofloxacin particles to cool down. Also described herein are otic formulations containing ciprofloxacin formed by the disclosed methods, and therapeutic use of such otic formulation for providing sustained release of ciprofloxacin into the ear for treating various otic disorders and conditions.Type: ApplicationFiled: July 1, 2015Publication date: January 7, 2016Inventors: Scott H. Coleman, Wei-Cheng Liaw, Jerry Wroblewski, Robert Savel
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Patent number: 9220796Abstract: Disclosed herein are methods of making sterilized ciprofloxacin compositions. In some embodiments, the method includes the steps of: (a) forming an aqueous suspension comprising ciprofloxacin particles; (b) heating the aqueous suspension comprising ciprofloxacin particles at a temperature range of from about 100° C. to about 120° C.; and (c) allowing the aqueous suspension comprising ciprofloxacin particles to cool down. Also described herein are otic formulations containing ciprofloxacin formed by the disclosed methods, and therapeutic use of such otic formulation for providing sustained release of ciprofloxacin into the ear for treating various otic disorders and conditions.Type: GrantFiled: July 1, 2015Date of Patent: December 29, 2015Assignee: OTONOMY, INC.Inventors: Scott H. Coleman, Wei-Cheng Liaw, Jerry Wroblewski, Robert Savel