Patents by Inventor Robert Siman
Robert Siman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230393133Abstract: The invention relates to methods for providing prognosis, diagnosis, and treatment of a mild traumatic brain injury (mTBI) in a computed tomography (CT)-negative subject. The invention further relates to monitoring the severity of brain damage resulting from TBI in a subject and determining the prognosis of a subject that has suffered from mTBI. This invention also relates to methods of predicting who is at risk for developing brain damage and long-term dysfunction.Type: ApplicationFiled: August 9, 2023Publication date: December 7, 2023Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventor: Robert SIMAN
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Patent number: 11761959Abstract: The invention relates to methods for providing prognosis, diagnosis, and treatment of a mild traumatic brain injury (mTBI) in a computed tomography (CT)-negative subject. The invention further relates to monitoring the severity of brain damage resulting from TBI in a subject and determining the prognosis of a subject that has suffered from mTBI. This invention also relates to methods of predicting who is at risk for developing brain damage and long-term dysfunction.Type: GrantFiled: March 14, 2014Date of Patent: September 19, 2023Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventor: Robert Siman
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Publication number: 20180217142Abstract: The invention relates to methods for providing prognosis, diagnosis, monitoring and treatment of a mild traumatic brain injury (mTBI) in a subject, including a sports-related concussion. The invention further relates to assessing the severity of brain damage resulting from mTBI in a subject, including in a subject who has not undergone a CT scan following the injury. For example, the methods of the invention can be used to determine the suitability for someone who has suffered a sports-related injury to return to play that sport. This invention also relates to methods of predicting risk for developing brain damage and long-term dysfunction in a subject having suffered mTBI.Type: ApplicationFiled: March 23, 2018Publication date: August 2, 2018Applicant: The Trustees of the University of PennsylvaniaInventor: Robert Siman
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Patent number: 9952214Abstract: The invention relates to methods for providing prognosis, diagnosis, monitoring and treatment of a mild traumatic brain injury (mTBI) in a subject, including a sports-related concussion. The invention further relates to assessing the severity of brain damage resulting from mTBI in a subject, including in a subject who has not undergone a CT scan following the injury. For example, the methods of the invention can be used to determine the suitability for someone who has suffered a sports-related injury to return to play that sport. This invention also relates to methods of predicting risk for developing brain damage and long-term dysfunction in a subject having suffered mTBI.Type: GrantFiled: November 10, 2014Date of Patent: April 24, 2018Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventor: Robert Siman
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Publication number: 20160041165Abstract: The invention relates to methods for providing prognosis, diagnosis, and treatment of a mild traumatic brain injury (mTBI) in a computed tomography (CT)-negative subject. The invention further relates to monitoring the severity of brain damage resulting from TBI in a subject and determining the prognosis of a subject that has suffered from mTBI. This invention also relates to methods of predicting who is at risk for developing brain damage and long-term dysfunction.Type: ApplicationFiled: March 14, 2014Publication date: February 11, 2016Inventor: Robert SIMAN
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Publication number: 20150056721Abstract: The invention relates to methods for providing prognosis, diagnosis, monitoring and treatment of a mild traumatic brain injury (mTBI) in a subject, including a sports-related concussion. The invention further relates to assessing the severity of brain damage resulting from mTBI in a subject, including in a subject who has not undergone a CT scan following the injury. For example, the methods of the invention can be used to determine the suitability for someone who has suffered a sports-related injury to return to play that sport. This invention also relates to methods of predicting risk for developing brain damage and long-term dysfunction in a subject having suffered mTBI.Type: ApplicationFiled: November 10, 2014Publication date: February 26, 2015Inventor: ROBERT SIMAN
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Patent number: 7256252Abstract: Methods for the biochemical and immunohistochemical detection of cell apoptosis are described. The methods utilize the detection and measurement of polypeptide fragments generated during apoptosis. Conditions associated with apoptosis may be detected by the methods of this invention. Methods are also presented for the screening of potential therapeutic compounds which inhibit or stimulate apoptosis. Kits for detection of apoptosis and diagnosis of diseases are also provided.Type: GrantFiled: December 29, 1999Date of Patent: August 14, 2007Assignee: Cephalon, Inc.Inventors: Robert Siman, Donna Bozyczko-Coyne, Sheryl L. Meyer
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Publication number: 20010012854Abstract: The present invention relates to methods for the use of specified inhibitors of multicatalytic protease (MCP) for use as inducers of programmed cell death (i.e., apoptosis) in tumor cells, and more particularly as anti-tumor agents. The present invention provides methods for inducing apoptosis in transformed cells, inhibiting proliferation of transformed cells, and inhibiting the growth of tumors using the MCP inhibitors.Type: ApplicationFiled: December 15, 1998Publication date: August 9, 2001Inventors: ROBERT SIMAN, JITESH P. JANI, RONALD H. GOLDFARB, QING PING DOU
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Patent number: 6057143Abstract: The present invention is directed to mammalian enzymatically active calpain produced in insect cells by recombinant means. Recombinant vectors and baculoviruses containing cDNA encoding the 80 kDa subunit, 30 kDa subunit, and both subunits are described. Methods for producing recombinant enzymatically active mammalian calpain are also described.Type: GrantFiled: July 17, 1997Date of Patent: May 2, 2000Assignee: Cephalon, Inc.Inventors: Sheryl L. Meyer, Richard W. Scott, Robert Siman
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Patent number: 6048703Abstract: Methods for the biochemical and immunohistochemical detection of cell apoptosis are described. The methods utilize the detection and measurement of polypeptide fragments generated during apoptosis. Conditions associated with apoptosis may be detected by the methods of this invention. Methods are also presented for the screening of potential therapeutic compounds which inhibit or stimulate apoptosis. Kits for detection of apoptosis and diagnosis of diseases are also provided.Type: GrantFiled: November 12, 1997Date of Patent: April 11, 2000Assignee: Cephalon, Inc.Inventors: Robert Siman, Donna Bozyczko-Coyne, Sheryl L. Meyer, Ratan Venkatraman Bhat
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Patent number: 5990083Abstract: Disclosed herein are inhibitors of the multicatalytic protease enzyme which are represented by the general formula: ##STR1## Constituent members and preferred constituent members are disclosed herein. Methodologies for making and using the disclosed compounds are also set forth herein.Type: GrantFiled: March 13, 1997Date of Patent: November 23, 1999Assignee: Cephalon, Inc.Inventors: Mohamed Iqbal, James L. Diebold, Robert Siman, Sankar Chatterjee, James C. Kauer
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Patent number: 5871712Abstract: The invention provides methods for detecting calpain activation by measuring levels of calpain-generated spectrin BDPs using antibodies that specifically bind to these spectrin BDPs, but not intact spectrin, or spectrin BDPs generated by other proteases. Also included in the invention are kits for diagnosing diseases associated with increased levels of calpain activation, and methods for screening for effective therapeutics for these diseases.Type: GrantFiled: January 26, 1996Date of Patent: February 16, 1999Assignee: Cephalon, Inc.Inventor: Robert Siman
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Patent number: 5869336Abstract: The present invention is directed to mammalian enzymatically active calpain produced in insect cells by recombinant means. Recombinant vectors and baculoviruses containing cDNA encoding the 80 kDa subunit, 30 kDa subunit, and both subunits are described. Methods for producing recombinant enzymatically active mammalian calpain are also described.Type: GrantFiled: July 17, 1997Date of Patent: February 9, 1999Assignee: Cephalon, Inc.Inventors: Sheryl L. Meyer, Richard W. Scott, Robert Siman
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Patent number: 5830870Abstract: Disclosed herein are inhibitors of the multicatalytic protease enzyme which are represented by the general formula: ##STR1## Constituent members and preferred constituent members are disclosed herein. Methodologies for making and using the disclosed compounds are also set forth herein.Type: GrantFiled: December 4, 1996Date of Patent: November 3, 1998Assignee: Cephalon, Inc.Inventors: Mohamed Iqbal, James L. Diebold, Robert Siman, Sankar Chatterjee, James C. Kauer
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Patent number: 5777194Abstract: Disclosed is non-human mouse homozygous for a targeted amyloid precursor protein-encoding gene comprising: (1) a human A.beta. peptide-encoding sequence in place of the native A.beta. peptide-encoding sequence; and (2) Swedish FAD mutations.Type: GrantFiled: April 23, 1996Date of Patent: July 7, 1998Assignee: Cephalon, Inc.Inventors: Richard W. Scott, Andrew G. Reaume, Stephen P. Trusko, Robert Siman
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Patent number: 5614649Abstract: Disclosed herein are inhibitors of the multicatalytic protease enzyme which are represented by the general formula: ##STR1## Constituent members and preferred constituent members are disclosed herein. Methodologies for making and using the disclosed compounds are also set forth herein.Type: GrantFiled: November 3, 1995Date of Patent: March 25, 1997Assignee: Cephalon, Inc.Inventors: Mohamed Iqbal, James L. Diebold, Robert Siman, Sankar Chatterjee, James C. Kauer
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Patent number: 5550262Abstract: Disclosed herein are inbibitors of the multicatalytic protease enzyme which are represented by the general formula: ##STR1## Constituent members and preferred constituent members are disclosed herein. Methodologies for making and using the disclosed compounds are also set forth herein.Type: GrantFiled: November 14, 1994Date of Patent: August 27, 1996Assignee: Cephalon, Inc.Inventors: Mohamed Iqbal, James L. Diebold, Robert Siman, Sankar Chatterjee, James C. Kauer
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Patent number: 5536639Abstract: The invention provides methods for detecting calpain activation by measuring levels of calpain-generated spectrin BDPs using antibodies that specifically bind to these spectrin BDPs, but not intact spectrin, or spectrin BDPs generated by other proteases. Also included in the invention are kits for diagnosing diseases associated with increased levels of calpain activation, and methods for screening for effective therapeutics for these diseases.Type: GrantFiled: March 25, 1994Date of Patent: July 16, 1996Assignee: Cephalon, Inc.Inventors: Robert Siman, Donna Bozyczko-Coyne