Patents by Inventor Robert Suto

Robert Suto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pin1-Modulating compounds and methods of use thereof
    Publication number: 20060106077
    Abstract: The invention is directed to modulators, e.g., inhibitors, of Pin1 and Pin1-related proteins and the use of such modulators for treatment of Pin1 associated states, e.g., for the treatment of cancer.
    Type: Application
    Filed: July 19, 2004
    Publication date: May 18, 2006
    Applicant: PINTEX PHARMACEUTICALS, INC.
    Inventors: Robert Suto, Timothy McKee, Thomas Tibbitts, Janusz Sowadski
  • Determination of a phosphorylation site in PPIase domain of Pin1 and uses therefor
    Publication number: 20060074222
    Abstract: This invention relates to methods of determining the prognosis of a subject with a Pin1 associated disorder by evaluating the levels of phosphorylated Pin1 in a biological sample. The invention also provides Pin1 polypeptides phosphorylated position 16, position 71, or both. The invention further relates to a crystal structure of a pPin1(71) polypeptide and a pPin1(16)(71) polypeptide. The invention also provides constitutively active mutants of Pin1 and modulators that are specific for the molecules. The invention further provides methods for determining if a subject is at risk of developing a Pin1 associated state by determining if a the subject has a mutation in Pin1 that renders the polypeptide constitutively active.
    Type: Application
    Filed: July 15, 2005
    Publication date: April 6, 2006
    Applicants: VERNALIS PLC, BETH ISRAEL DEACONESS MEDICAL CENTER
    Inventors: Kun Lu, Janusz Sowadski, Robert Suto, Timothy McKee, Amy Kimzey, Futoshi Suizu
  • Pin1-modulating compounds and methods of use thereof
    Publication number: 20050049267
    Abstract: The invention is directed to modulators, e.g., inhibitors, of Pin1 and Pin1-related proteins and the use of such modulators for treatment of Pin1 associated states, e.g., for the treatment of cancer.
    Type: Application
    Filed: March 3, 2003
    Publication date: March 3, 2005
    Applicant: Pintex Pharmaceuticals, Inc.
    Inventors: Robert Suto, Timothy McKee, Thomas Tibbitts, Janusz Sowadski