Abstract: A new computer mouse is disclosed to prevent strain injuries to the hand and wrist and prevent or alleviate the symptoms associated with Carpel Tunnel Syndrome (CTS) for those who are repetitive users of computer mouse devices. The mouse is designed to leave the carpal tunnel of a user of the mouse substantially open, thus precluding tunnel narrowing and the symptoms resulting therefrom. The mouse is also designed to maximize comfort of the user, alleviate wrist bend associated with use of the mouse, and is adaptable to different size hands.

Abstract: A new ergonomic accoutrement adapted to be attached to a computer mouse was developed to prevent strain injuries to the hand and wrist and prevent or alleviate the symptoms associated with Carpel Tunnel Syndrome (CTS) for those who are repetitive users of computer mouse devices. The accoutrement is designed to leave the carpal tunnel of the user of a computer mouse substantially open, thus precluding tunnel narrowing and the symptoms resulting therefrom. The accoutrement is also designed to maximize comfort of the user, alleviate wrist bend associated with use of the mouse, and be adaptable to different size hands.

Abstract: A door guard for hotel/motel doors comprises two articles, one article to be attached to a door, and another article to be attached to a door frame. One article is attached to the door, including a hook element adapted to receive a latch member of the door guard and attached to an inside surface of the door; and a damping element, composed of a sound dampening material, attached to an outside surface of the door. Another article is attached to the door frame, including a hinge element for connecting the article to the door frame; and a latch member pivotally connected to the hinge element. Another sound damping element, also composed of a sound dampening material, is disposed between the hinge element and the latch member. When the door guard is released and the door closes, the attached articles reduce the sound and/or vibrations, which are disturbing to hotel/motel guests, that occur when the closing door impacts the door guard and door frame.

Abstract: A door guard for hotel/motel doors comprises two articles, one article to be attached to a door, and another article to be attached to a door frame. One article is attached to the door, including a hook element adapted to receive a latch member of the door guard and attached to an inside surface of the door; and a damping element, composed of a sound dampening material, attached to an outside surface of the door. Another article is attached to the door frame, including a hinge element for connecting the article to the door frame; and a latch member pivotally connected to the hinge element. Another sound damping element, also composed of a sound dampening material, is disposed between the hinge element and the latch member. When the door guard is released and the door closes, the attached articles reduce the sound and/or vibrations, which are disturbing to hotel/motel guests, that occur when the closing door impacts the door guard and door frame.

Abstract: The invention concerns a 4-aryl-imidazole derivative having the formula I ##STR1## wherein X is 0 or NOH,Y is NR.sub.3,Ar is a group selected from phenyl, naphthyl, tetrahydronaphthyl, and biphenyl,R is one to four substituents independently selected from hydrogen, hydroxy, lower alkyl, lower alkoxy, lower thioalkyl, cycloalkyl, halogen, CF.sub.3, NO.sub.2, and O--ALK--NR.sub.1 R.sub.2, in which ALK is a saturated aliphatic hydrocarbon group having 2-6 carbon atoms, and R.sub.1 and R.sub.2 are independently hydrogen or lower alkyl, or form, together with the nitrogen atom to which they are bonded, a heterocyclic ring, andR.sub.3 is hydrogen or a lower alkyl; or a pharmaceutically acceptable salt thereof, with the proviso that 4-(4-chlorophenyl)-thiazole-2-carboxamide is excluded.

Abstract: The invention relates to the use of the benzo[b]-thiophene-2-carboximidamide derivative having formula I ##STR1## or pharmaceutically acceptable salts thereof, for the preparation of a medicament which is suitable for the treatment of heart failure, having high bioavailability without inducing nausea, vomiting and/or restlessness.

Abstract: The invention concerns a 4-aryl-thiazole or imidazole derivative having the formula I ##STR1## wherein X is 0 or NOH,Y is S or NR.sub.3,Ar is a group selected from phenyl, naphthyl, tetrahydronaphthyl, and biphenyl,R is one to four substituents independently selected from hydrogen, hydroxy, lower alkyl, lower alkoxy, lower thioalkyl, cycloalkyl, halogen, CF.sub.3, NO.sub.2, and O-ALK-NR.sub.1 R.sub.2, in which ALK is a saturated aliphatic hydrocarbon group having 2-6 carbon atoms, and R.sub.1 and R.sub.2 are independently hydrogen or lower alkyl, or form, together with the nitrogen atom to which they are bonded, a heterocyclic ring, andR.sub.3 is hydrogen or a lower alkyl; or a pharmaceutically acceptable salt thereof, with the proviso that 4-(4-chlorophenyl)-thiazole-2-carboxamide is excluded.

Abstract: The invention provides novel pregnane derivatives having the formula: ##STR1## wherein X=F, Cl or Br; R.sub.1 =F or Cl; R.sub.2 =H(.beta.OH) or O; R.sub.3 =alkyl(1-4 C); R.sub.4 =alkyl(1-4 C); and the dotted line indicates the optional presence of a double bond.The novel compounds have been found to possess immunomodulating properties.

Abstract: A method is provided for treating patients suffering from or susceptible to bronchoconstriction, particularly for patients suffering from an asthmatic attach which comprises the use of benzothiophene, benzofuran, dihydronaphthalene or indene derivatives represented by formula I ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 is independently H, (1-4C) alkyl, (1-4C) halogen substituted alkyl, OH, (1-4C) alkoxy, (1-4C) halogen substituted alkoxy, NO.sub.2, CN, halogen, an unsubstituted or (1-4C) alkyl substituted amino group, or wherein two adjacent groups R.sup.1, R.sup.2, R.sup.3 or R.sup.4 together form methylenedioxy;X is S, O or (CH.sub.2).sub.m in which m is 1 or 2;R.sup.5 is H or (1-4C) alkyl;R.sup.6 is H, NH.sub.2 or (1-4C) alkyl;R.sup.7 is H, (1-4C) alkyl or OR.sup.8 in whichR.sup.8 is H, (1-4C) alkyl or (1-8C) acyl;and its pharmaceutically acceptable salts for the preparation of a medicament with bronchodilator activity.

Abstract: The invention relates to pyridazinone compounds of the general formula I: ##STR1## wherein R.sup.1 represents one to four substituents, which may be the same or different and are selected from H, OH, halogen, NO.sub.2, unsubstituted or C1-C4 alkyl substituted amino, C1-C4 alkyl, C1-C4 halogen substituted alkyl, O--ALK--NR.sup.4 R.sup.5, C1-C4 alkoxy, whereby two substituents taken together may also represent a methylenedioxy group;R.sup.2 and R.sup.3 represent independently H or C1-C4 alkyl;R.sup.4 and R.sup.5 represent independently H or C1-C4 alkyl, or form together with the nitrogen a 5- or 6- membered ring;X represents S or O;the dotted line represents an optional bond;and their pharmaceutically acceptable salts.

Abstract: The invention relates to compounds of the general formula I ##STR1## wherein R.sub.1 represents one up to and including four, the same or different substituents selected from alkyl(1-6 C), alkoxy(1-6 C), hydroxy, halogen, NO.sub.2, CF.sub.3 or the group --NR.sub.5 R.sub.6, whereby two substituents taken together may also represent a methylene-dioxy group,X represents nitrogen or the group ##STR2## n has the value 0, 1 or 2, R.sub.3 represents one of the moieties: ##STR3## the latter meaning of R.sub.3 (amide) only under the condition that for X is nitrogen the meaning of R.sub.1 is limited to substituents selected from hydroxy, alkoxy(1-6 C) and methylenedioxy, and R.sub.4, R.sub.5 and R.sub.6 represent hydrogen or alkyl(1-6 C), and pharmaceutically acceptable salts thereof, suitable in the treatment of heart failure.

Abstract: The invention relates to compounds of the general formula I ##STR1## wherein R.sub.1 represents one up to and including four, the same or different substituents selected from alkyl(1-6 C), alkoxy(1-6 C), hydroxy, halogen, NO.sub.2, CF.sub.3 or the group --NR.sub.5 R.sub.6,whereby two substituents taken together may also represent a methylene-dioxy group,X represents a member selected from ##STR2## --CH.sub.2 --CH.sub.2 -- and --CH.dbd.CH--, n has the value 0, 1 or 2,R.sub.3 represents one of the moieties: ##STR3## and R.sub.2, R.sub.4, R.sub.5 and R.sub.6 represent hydrogen or alkyl(1-6 C),and pharmaceutically acceptable salts thereof, suitable in the treatment of heartfailure.

Abstract: The invention relates to compounds of the general formula I ##STR1## wherein R.sub.1 represents one up to and including four, the same or different substituents selected from alkyl(1-6 C), alkoxy(1-6 C), hydroxy, halogen, NO.sub.2 CF.sub.3 or the group --NR.sub.5 R.sub.6, whereby two substituents taken together may also represent a methylene-dioxy group,X represents nitrogen or the group ##STR2## n has the value 0, 1 or 2, R.sub.3 represents one of the moieties: ##STR3## the latter meaning of R.sub.3 (amide) only under the condition that for X is nitrogen the meaning of R.sub.1 is limited to substituents selected from hydroxy, alkoxy(1-6 C) and methylenedioxy, and R.sub.4, R.sub.5 and R.sub.6 represent hydrogen or alkyl(1-6 C), and pharmaceutically acceptable salts thereof, suitable in the treatment of heart failure.

Abstract: The present invention relates to novel 21-alkylated steroids of the pregnane series having the formula: ##STR1## wherein R.sub.1 =alkyl (1-4 C); R.sub.2 =carboxyacyl (1-18 C); X=H, F or Cl; Y=O, H(OH), H(lower acyloxy), H(F) or H(Cl) with the proviso that Y is not H(F) when X is F; and the dotted line indicates the optional presence of a double bond, to processes for their preparation and to pharmaceutical compositions containing same.The novel compounds possess strong anti-inflammatory properties, when applied locally and cause little or systemic, thymolytic, adrenolytic and salt-retaining effects.