Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand with open ends around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The preferred embodiment of the catheter includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.

Abstract: A series of substituted imidazo[1,2-b]pyridazine derivatives as defined herein, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.

Abstract: A vehicle include an interior cabin including a plurality of structural components, a plurality of electrical devices within the interior cabin, a power supply, and an electrical signal distribution system mounted to at least one of the plurality of structural components and electrically coupled to the power supply and the plurality of electrical devices. The electrical signal distribution system includes a printed circuit board (PCB), and a plurality of outlets coupled to the PCB. The plurality of outlets electrically couple to the plurality of electrical devices. The electrical signal distribution system provides electrical signals to the plurality of electrical devices.

Abstract: An electrical multi-connector feedthrough panel comprising a frame configured to couple with a structure and to seal, at least in part, a penetration in the structure across a pressure differential, wherein a first pressurized environment is disposed on one side of the sealed penetration, and wherein a second pressurized environment, different than the first pressurized environment, is disposed on an opposite side of the sealed penetration a plurality of electrical connector insert shells monolithically formed with the frame, each of the plurality of electrical connector insert shells protruding from opposite sides of the frame to form a respective passage through the frame and being configured to sealingly couple with at least one electrical butt connector to thereby seal the respective passage; and an electrically conductive coating disposed on the frame and on each of the plurality of electrical connector insert shells to thereby form an electrical bonding surface.

Abstract: A vehicle include an interior cabin including a plurality of structural components, a plurality of electrical devices within the interior cabin, a power supply, and an electrical signal distribution system mounted to at least one of the plurality of structural components and electrically coupled to the power supply and the plurality of electrical devices. The electrical signal distribution system includes a printed circuit board (PCB), and a plurality of outlets coupled to the PCB. The plurality of outlets electrically couple to the plurality of electrical devices. The electrical signal distribution system provides electrical signals to the plurality of electrical devices.

Abstract: An electrical multi-connector feedthrough panel comprising a frame configured to couple with a structure and to seal, at least in part, a penetration in the structure across a pressure differential, wherein a first pressurized environment is disposed on one side of the sealed penetration, and wherein a second pressurized environment, different than the first pressurized environment, is disposed on an opposite side of the sealed penetration a plurality of electrical connector insert shells monolithically formed with the frame, each of the plurality of electrical connector insert shells protruding from opposite sides of the frame to form a respective passage through the frame and being configured to sealingly couple with at least one electrical butt connector to thereby seal the respective passage; and an electrically conductive coating disposed on the frame and on each of the plurality of electrical connector insert shells to thereby form an electrical bonding surface.

Abstract: An electrical multi-connector feedthrough panel for sealing a penetration in a structure across a pressure differential, the panel including a frame having a first environmental interface surface and a second environmental interface surface configured to couple with the structure so that the first environmental interface surface and the second environmental interface surface span the penetration so as to at least in part seal the penetration, and a plurality of electrical connector insert shells monolithically formed with the frame, each of the plurality of electrical connector insert shells being configured to sealingly couple with at least one electrical connector, where the first environmental interface surface is disposed between the plurality of connector shells so as to be in fluid communication with a first pressurized environment, and the second environmental interface surface is disposed between the plurality of connector shells so as to be in fluid communication with a second pressurized environment

Abstract: A vehicle include an interior cabin including a plurality of structural components, a plurality of electrical devices within the interior cabin, a power supply, and an electrical signal distribution system mounted to at least one of the plurality of structural components and electrically coupled to the power supply and the plurality of electrical devices. The electrical signal distribution system includes a printed circuit board (PCB), and a plurality of outlets coupled to the PCB. The plurality of outlets electrically couple to the plurality of electrical devices. The electrical signal distribution system provides electrical signals to the plurality of electrical devices.

Abstract: An electrical multi-connector feedthrough panel for sealing a penetration in a structure across a pressure differential, the panel including a frame having a first environmental interface surface and a second environmental interface surface configured to couple with the structure so that the first environmental interface surface and the second environmental interface surface span the penetration so as to at least in part seal the penetration, and a plurality of electrical connector insert shells monolithically formed with the frame, each of the plurality of electrical connector insert shells being configured to sealingly couple with at least one electrical connector, where the first environmental interface surface is disposed between the plurality of connector shells so as to be in fluid communication with a first pressurized environment, and the second environmental interface surface is disposed between the plurality of connector shells so as to be in fluid communication with a second pressurized environment

Abstract: A vehicle include an interior cabin including a plurality of structural components, a plurality of electrical devices within the interior cabin, a power supply, and an electrical signal distribution system mounted to at least one of the plurality of structural components and electrically coupled to the power supply and the plurality of electrical devices. The electrical signal distribution system includes a printed circuit board (PCB), and a plurality of outlets coupled to the PCB. The plurality of outlets electrically couple to the plurality of electrical devices. The electrical signal distribution system provides electrical signals to the plurality of electrical devices.

Abstract: A method and apparatus for establishing a wire network for a platform. The apparatus for establishing a wire network for an aircraft comprises a wire manager and a layout manager. The wire manager sorts a plurality of wires for the aircraft into a plurality of bundles based on a plurality of categories established for the plurality of wires with respect to operation of the aircraft. The plurality of categories includes an essential category and the plurality of bundles includes a primary bundle corresponding to the essential category. The layout manager generates a primary layout output for the primary bundle based on an available space within the aircraft. Forming and installing a primary wire harness corresponding to the primary bundle in the aircraft based on the primary layout output independently of a remaining portion of the plurality of bundles improves a build efficiency of the aircraft.

Abstract: A method and apparatus for establishing a wire network for a platform. The apparatus for establishing a wire network for an aircraft comprises a wire manager and a layout manager. The wire manager sorts a plurality of wires for the aircraft into a plurality of bundles based on a plurality of categories established for the plurality of wires with respect to operation of the aircraft. The plurality of categories includes an essential category and the plurality of bundles includes a primary bundle corresponding to the essential category. The layout manager generates a primary layout output for the primary bundle based on an available space within the aircraft. Forming and installing a primary wire harness corresponding to the primary bundle in the aircraft based on the primary layout output independently of a remaining portion of the plurality of bundles improves a build efficiency of the aircraft.

Abstract: A method for interconnecting electronic equipment within an aircraft includes installing a multi-dimensional backplane within the aircraft across a plurality of frame bays associated with the aircraft, the backplane including a plurality of connectors mounted thereon, contacts associated with the connectors interconnected by electrical conductors formed within the backplane, attaching shipside wiring to a first portion of the connectors on the backplane, and attaching electrical connectors of the electronic equipment to corresponding connectors on the backplane.

Abstract: A method for interconnecting electronic equipment within an aircraft is described. The method includes installing a multi-dimensional backplane within the aircraft, the backplane including a plurality of connectors mounted thereon, contacts associated with the connectors interconnected by electrical conductors formed within the backplane, attaching shipside wiring to a first portion of the connectors on the backplane, and attaching electrical connectors of the electronic equipment to corresponding connectors on the backplane.

Abstract: A measuring system for measuring at a plurality of sampling points, a signal representative of the instantaneous value of a physical parameter, wherein a signal representative of the instantaneous value of the physical parameter being measured is utilized as a reference signal against which the next following signal is compared and so on. The system includes means for passing to an output, signals similar to, or within a predetermined limit of, the immediately preceding signals. A particular application of this measuring system is in the measurement of the temperature of living bodies wherein the changes in temperature are transmitted via a pulse width modulation telemetry system to a receiver incorporating the measuring system. By means of continually up-dating the reference signal it is possible to reject any signal which due to some reason such as radio interference is unacceptable because it varies too much from the previous reading.

Abstract: A measuring system in which a signal representative of the instantaneous value of a physical parameter being measured is utilized as a reference signal against which the next following signal is compared and so on. The system includes means for passing to an output, signals similar to, or within a predetermined limit of, the immediately preceding signals. A particular application of this measuring system is in the measurement of the temperature of living bodies wherein the changes in temperature are transmitted via a pulse width modulation telemetry system to a receiver incorporating the measuring system. By means of continually up-dating the reference signal it is possible to reject any signal which due to some reason such as radio interference is unacceptable because it varies too much from the previous reading.