Abstract: In one embodiment, a method includes receiving sensor data associated with an object external to a vehicle. The sensor data includes a sequence of data packets. Each data packet corresponds to a time frame in a sequence of time frames. The method includes determining a classification of the object based at least on the sensor data, determining that a particular data packet corresponding to a particular time frame in the sequence of time frames is corrupt or missing, generating a replacement data packet based on one or more data packets that correspond to one or more time frames adjacent to the particular time frame, generating a sequence of visual representations of the object corresponding to the sequence of time frames. At least one visual representation in the sequence of visual representations corresponding to the particular time frame is generated based on the replacement data packet.

Abstract: The disclosed computer-implemented method may include identifying and notifying requestors that may be candidates for a particular autonomous vehicle in order to find those candidates that may be willing or able to relax their travel constraints to match the autonomous vehicle. A request flow may involve surfacing the potential option of matching to an autonomous vehicle before setting a specific destination. For example, the request flow may involve determining that an autonomous vehicle is sufficiently near an in-session potential requestor. Before the potential requestor enters a specific destination, the request flow may present the possibility of the potential requestor being matched with the autonomous vehicle. In some examples, the request flow may then provide available drop-off locations that are compatible with the autonomous vehicle for selection by the potential requestor. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: Provided herein are recombinant nucleic acids encoding a T cell receptor (TCR) fusion protein (TFP) and an interleukin-15 (IL-15) polypeptide and/or an interleukin-15 receptor alpha (IL-15R?) polypeptide, modified T cells expressing the encoded molecules, and methods of use thereof for the treatment of diseases, including cancer.

Abstract: In one embodiment, a method includes determining a plurality of available locations for a vehicle to pick up or drop off a user in an area based on sensor data that is captured by the vehicle and is associated with physical characteristics of the area. The method includes calculating a viability value for each of the plurality of available locations. The viability value is calculated based on the physical characteristics of the area as determined from the sensor data. The method includes ranking the plurality of available locations according to the viability values of the plurality of available locations. An available location with a higher viability value is ranked above an available location with a lower viability value. The method includes sending instructions to present, on a computing device, one or more selectable locations of the plurality of available locations based on the ranking.

Abstract: Provided herein are recombinant nucleic acids encoding T cell receptor (TCR) fusion proteins (TFPs), modified ?? T cells expressing the encoded molecules, and methods of use thereof for the treatment of diseases, including cancer.

Abstract: Disclosed herein are methods for treatment of a mesothelin (MSLN)-expressing cancer in a human subject comprising administration of, e.g., a plurality of anti-MSLN T cell receptor fusion protein (TFP)-expressing T cells. A ratio of CD4+ to CD8+ T cells in a sample from the human subject may have been determined before the administration of the plurality of anti-MSLN TFP-expressing T cells. The plurality of anti-MSLN TFP-expressing T cells may comprise a pre-determined ratio of CD4+ to CD8+ T cells.

Abstract: The disclosed computer-implemented method may include identifying and notifying requestors that may be candidates for a particular autonomous vehicle in order to find those candidates that may be willing or able to relax their travel constraints to match the autonomous vehicle. A request flow may involve surfacing the potential option of matching to an autonomous vehicle before setting a specific destination. For example, the request flow may involve determining that an autonomous vehicle is sufficiently near an in-session potential requestor. Before the potential requestor enters a specific destination, the request flow may present the possibility of the potential requestor being matched with the autonomous vehicle. In some examples, the request flow may then provide available drop-off locations that are compatible with the autonomous vehicle for selection by the potential requestor. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: The disclosed computer-implemented method may include identifying and notifying requestors that may be candidates for a particular autonomous vehicle in order to find those candidates that may be willing or able to relax their travel constraints to match the autonomous vehicle. A request flow may involve surfacing the potential option of matching to an autonomous vehicle before setting a specific destination. For example, the request flow may involve determining that an autonomous vehicle is sufficiently near an in-session potential requestor. Before the potential requestor enters a specific destination, the request flow may present the possibility of the potential requestor being matched with the autonomous vehicle. In some examples, the request flow may then provide available drop-off locations that are compatible with the autonomous vehicle for selection by the potential requestor. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: The disclosed computer-implemented method may include identifying and notifying requestors that may be candidates for a particular autonomous vehicle in order to find those candidates that may be willing or able to relax their travel constraints to match the autonomous vehicle. A request flow may involve surfacing the potential option of matching to an autonomous vehicle before setting a specific destination. For example, the request flow may involve determining that an autonomous vehicle is sufficiently near an in-session potential requestor. Before the potential requestor enters a specific destination, the request flow may present the possibility of the potential requestor being matched with the autonomous vehicle. In some examples, the request flow may then provide available drop-off locations that are compatible with the autonomous vehicle for selection by the potential requestor. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: The invention relates to polypeptides that block or inhibit the interleukin-1 receptor 1 (IL-1R1), the interaction of IL-1beta with IL-1R1 or the interaction between IL-1R1 and interleukin-1 receptor accessory protein (IL-1RaCP). The invention relates specifically to therapeutic polypeptides that target specifically IL-1R1 present on tumor cells, cancer stem cells, and cancer stem cells which are resistant to chemotherapy or radiotherapy. The invention specifically relates to cancer stem cells (CSC) that express IL-1R1 to which said inhibitors bind. Finally the invention relates to a combination therapy comprising killing tumorigenic differentiating cancer cells by means of standard chemo- or radiotherapy and prior or subsequent to that applying IL-1R1 inhibitors which target specifically CSC and strip the tumor of its capacity to generate cancer cell progeny.

Abstract: A footwear sole assembly (10) for walking with a rolling action is described. An elastically compressible midsole element (33) is provided with a rolling element (40) situated in and extending over a portion of the length and over at least a portion of the width of the midsole element (33). The rolling element (40) consists at least partially of a resilient material and is disposed at least in that region of the midsole (33) which is opposite to the arch of the wearer's foot. This shoe offers the rolling gait advantages of the well known MBT shoe, but has a different construction which enables it to retain the outward appearance of conventional shoes such as trainers.

Abstract: A footwear sole assembly (10) for walking with a rolling action is described. An elastically compressible midsole element (33) is provided with a rolling element (40) situated in and extending over a portion of the length and over at least a portion of the width of the midsole element (33). The rolling element (40) consists at least partially of a resilient material and is disposed at least in that region of the midsole (33) which is opposite to the arch of the wearer's foot. This shoe offers the rolling gait advantages of the well known MBT shoe, but has a different construction which enables it to retain the outward appearance of conventional shoes such as trainers.