Abstract: The present disclosure relates to an online platform for out of home advertising. The online platform may allow various advertisers to search for advertising panels (e.g., digital billboards), select available time periods for an advertising panel, upload an advertisement (“ad”), and have the ad displayed on the advertising panel. An advertiser can search for advertising panels using one or more search parameters (e.g., geographical location and demography of target audience). The online platform may also allow advertising panel owners to publish their advertising panels, manage availability, and approve or reject ads for display. The online platform may generate reports relating to the advertising panels.

Abstract: The present invention relates to a new use of compounds that are angiotensin II (Ang II) agonists, more particularly agonists of the Ang II type 2 receptor (the AT2 receptor), and especially agonists that bind selectively to the AT2 receptor, for the prevention or treatment of muscular dystrophy or complications associated with muscular dystrophy.

Abstract: It relates to a pharmaceutical combination comprising a KRAS G12C inhibitor, in particular 1-{6-[(4M)-4-(5-Chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl]-2-azaspiro [3.3] heptan-2-yl} prop-2-en-1-one (Compound A) and one or more therapeutically active agents selected from a SHP2 inhibitor (e.g. TNO155) and a PD-1 inhibitor, pharmaceutical compositions comprising the same; and methods of using such combinations and compositions in the treatment or prevention of a cancer or a tumor, in particular wherein the cancer or tumor is KRAS G12C mutated.

Abstract: The present application relates to an aluminum alloy, in particular a cast aluminum alloy, a method for producing an engine component, in particular a piston for an internal combustion engine, in which an aluminum alloy is cast using the gravity die casting method, and an engine component, in particular a piston for an internal combustion engine, consisting at least partially of an aluminum alloy. The aluminum alloy consists of the following alloy elements: silicon: 10% by weight to <13% by weight, nickel: up to <0.6% by weight, copper: 1.5% by weight to <3.6% by weight, magnesium: 0.5% by weight to 1.5% by weight, iron: 0.1% by weight to 0.7% by weight, manganese: 0.1 to 0.4% by weight, zirconium: >0.1 to <0.3% by weight, vanadium: >0.08 to <0.2% by weight, titanium: 0.05 to <0.2% by weight, phosphorus: 0.0025 to 0.008% by weight, and the remainder being aluminum and unavoidable impurities. Furthermore, the microstructure of the alloy has spheroidized primary precipitates.

Abstract: The invention relates to a method for determining the absolute value of the flow velocity (v) of a particle-transporting medium. At least two measurement laser beams (L_i) with linearly independent, non-orthogonal measurement directions (b_i) are emitted. The measurement laser beams (L_i) scattered at particles are detected and one measurement signal (m_i) is generated in each case for each measurement laser beam (L_i).

Abstract: A treatment system and process includes a ribbon beam ion source that is configured to implant ions into a product to modify a portion of the product; multiple means of controlling the temperature of the product; the means including radiative conduction, gas conduction to a heatsink by means of a gas cushion, adjustment of the ion beam density at the product, adjustment of the ion beam intensity at the product and ion beam acceleration parameters, and adjustment of the ion dose to the product b; and a product movement system configured to move the product through the treatment system past the ribbon beam ion source. The treatment system further includes a system controller configured to control at least one the following: the gas cushion system, the ribbon beam ion source, the temperature control system, the heatsink, and the product movement system.

Abstract: A laser sensor module includes a laser diode configured emit a laser beam, an electrical driver configured to supply the laser diode with a driving current to stimulate emission of the laser beam, a detector, and an optical arrangement configured to focus the laser beam to a focus region. The laser diode is arranged to emit the laser beam through the optical arrangement to the focus region. The optical arrangement comprises an emission window. The detector is arranged to determine an interference signal. The laser sensor module comprises a soiling detection unit configured to vary a wavelength of the laser beam with a variation amplitude over a predetermined time period to provide a soiling detection signal indicative of a soiling of the emission window based on an interference signal during the wavelength variation of the laser beam.

Abstract: In one or more embodiments, the present invention provides a novel approach to the addition of plasticizers for softening TPUs, i.e., lowering the durometer and the melt viscosity. This approach involves incorporating bonded sulfonate groups with quaternary ammonium counterions into the TPU. In one or more embodiments of the present invention, the softening of TPU is achieved by incorporating an ionic diol, such as N,N-bis (2-hydroxyethyl)-2-aminoethane-sulfonic acid (BES), coupled with various bulky alkyl ammonium cations, during the chain extension step of the TPU synthesis. It is believed that that steric hindrance of the bulky quaternary ammonium groups weakens the dipole-dipole interactions of the sulfonate groups and/or lowers the crystallinity of the hard block, thereby creating additional free volume that softens the polymer and lowers the melt viscosity.

Abstract: In one or more embodiments, the present invention provides a novel approach to the addition of plasticizers for softening TPUs, i.e., lowering the durometer and the melt viscosity. This approach involves incorporating bonded sulfonate groups with quaternary ammonium counterions into the TPU. In one or more embodiments of the present invention, the softening of TPU is achieved by incorporating an ionic diol, such as N,N-bis (2-hydroxyethyl)-2-aminoethane-sulfonic acid (BES), coupled with various bulky alkyl ammonium cations, during the chain extension step of the TPU synthesis. It is believed that that steric hindrance of the bulky quaternary ammonium groups weakens the dipole-dipole interactions of the sulfonate groups and/or lowers the crystallinity of the hard block, thereby creating additional free volume that softens the polymer and lowers the melt viscosity.

Abstract: Embodiments of the invention are directed to a method for creating a secure volume. A method includes adhering a flexible circuit to a surface of an enclosure. A first portion of the flexible circuit extends outward from the perimeter of the enclosure. A second portion of the flexible circuit is adhered to the center portion of the enclosure. Pressure is applied to the flexible circuit to ensure that it is affixed to the enclosure. The flexible circuit and the enclosure are then subjected to an annealing temperature. The duration and temperature are based on the adhesive and flexible circuit material. The extended portion of the flexible circuit is coated with an adhesive and folded over the second portion of the flexible circuit. Pressure is applied to the folded flexible circuit. The folded flexible circuit is then subjected to an annealing temperature.

Abstract: A method reduces false-positive particle counts detected by an interference particle sensor module, which has a laser and a light detector. The method including: emitting laser light; providing a high-frequency signal during the emission of the laser light, a modulation frequency of the high-frequency signal being between 10-500 MHz; detecting an optical response by the light detector in reaction to the emitted laser light while providing the high-frequency signal, which is arranged such that a detection signal caused by a macroscopic object positioned between a first and second distance is reduced in comparison to a detection signal caused by the macroscopic object at the same position without providing the high-frequency signal. The high-frequency signal is provided to a tuning structure of the particle sensor module which is arranged to modify a resonance frequency of an optical resonator comprised by the laser sensor module upon reception of the high-frequency signal.

Abstract: An optical particle sensor device comprises an optical emitter device for emitting a multitude of measurement laser beams; a detector device for detecting the measurement laser beams scattered on particles in the vicinity of the optical particle sensor device and for generating a single measuring signal assigned to this for each measurement laser beam; and an evaluation device for determining at least one estimated particle value for the number of particles per volume using at least one single measurement signal, wherein the evaluation device determines at least two estimated particle values for the number of particles per volume, which are based on at least partially different single measurement signals and/or a different number of single measurement signals, and on the basis of at least part of the estimated particle values, determines at least one output value for the particle load.

Abstract: A process for deforming a flex circuit using a fixture assembly including a base plate having a recess, a wrinkle reducer plate, a stiffening block and a punch. The process including heating the fixture assembly; applying a force to the punch deforming the flex circuit into the recess in the base plate; holding the punch in contact with the flex circuit while heating the fixture assembly; cooling the fixture assembly with the punch in contact with the flex circuit; subsequent to cooling the fixture assembly, removing the force of the punch; and removing the flex circuit from the fixture assembly. The flex circuit having a recessed portion resulting from deforming the flex circuit into the recess in the base plate and a flat portion surrounding the recessed portion.

Abstract: The present invention relates to a new use of compounds that are angiotensin II (Ang II) agonists, more particularly agonists of the Ang II type 2 receptor (the AT2 receptor), and especially agonists that bind selectively to the AT2 receptor, for the prevention or treatment of muscular dystrophy or complications associated with muscular dystrophy.

Abstract: A system for determining a particle contamination and a method for determining a particle contamination in a measurement environment is provided in which individual particles in the measurement environment are detected (S1), wherein a) an estimate of the number of particles per volume in the measurement environment is ascertained (S2), b) an estimate of the number of particles per volume and characterization information describing the particle source in the measurement information are taken as a basis for ascertaining an output value for the particle contamination in the measurement environment (S3), and c) context-related data are made available and the characterization information is estimated on the basis of the available context-related data (S4).

Abstract: Embodiments of the invention are directed to a method for creating a secure volume. A method includes adhering a flexible circuit to a surface of an enclosure. A first portion of the flexible circuit extends outward from the perimeter of the enclosure. A second portion of the flexible circuit is adhered to the center portion of the enclosure. Pressure is applied to the flexible circuit to ensure that it is affixed to the enclosure. The flexible circuit and the enclosure are then subjected to an annealing temperature. The duration and temperature are based on the adhesive and flexible circuit material. The extended portion of the flexible circuit is coated with an adhesive and folded over the second portion of the flexible circuit. Pressure is applied to the folded flexible circuit. The folded flexible circuit is then subjected to an annealing temperature.

Abstract: The invention relates to a method for determining the absolute value of the flow velocity (v) of a particle-transporting medium. At least two measurement laser beams (L_i) with linearly independent, non-orthogonal measurement directions (b_i) are emitted. The measurement laser beams (L_i) scattered at particles are detected and one measurement signal (m_i) is generated in each case for each measurement laser beam (L_i).

Abstract: A process for deforming a flex circuit using a fixture assembly including a base plate having a recess, a wrinkle reducer plate, a stiffening block and a punch. The process including heating the fixture assembly; applying a force to the punch deforming the flex circuit into the recess in the base plate; holding the punch in contact with the flex circuit while heating the fixture assembly; cooling the fixture assembly with the punch in contact with the flex circuit; subsequent to cooling the fixture assembly, removing the force of the punch; and removing the flex circuit from the fixture assembly. The flex circuit having a recessed portion resulting from deforming the flex circuit into the recess in the base plate and a flat portion surrounding the recessed portion.

Abstract: A system for determining a particle contamination and a method for determining a particle contamination in a measurement environment, is provided in which individual particles in the measurement environment are detected (S1), wherein a) an estimate of the number of particles per volume in the measurement environment is ascertained (S2), b) an estimate of the number of particles per volume and characterization information describing the particle source in the measurement information are taken as a basis for ascertaining an output value for the particle contamination in the measurement environment (S3), and c) context-related data are made available and the characterization information is estimated on the basis of the available context-related data (S4).