Patents by Inventor Robert Westwood
Robert Westwood has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240087142Abstract: A method of tracking a user's toothcare activity comprises receiving video images of a user's face during, e.g. a toothbrushing session, and identifying, in each of a plurality of frames of the video images, predetermined features of the user's face. The features include at least two invariant landmarks associated with the user's face and one or more landmarks selected from at least mouth feature positions and eye feature positions. Predetermined marker features of a toothcare appliance, e.g. a brush in use are identified in each of the plurality of frames of the video images. From the at least two invariant landmarks associated with the user's nose, a measure of inter-landmark distance is determined. An appliance length normalised by the inter-landmark distance is determined. From the one or more landmarks selected from at least mouth feature positions and eye feature positions, one or more appliance-to-facial feature distances each normalised by the inter-landmark distance is determined.Type: ApplicationFiled: March 12, 2021Publication date: March 14, 2024Applicant: Conopco, Inc., d/b/a UNILEVERInventors: Timur ALMAEV, Anthony BROWN, William Westwood PRESTON, Robert Lindsay TRELOAR, Michel François VALSTAR, Ruediger Zillmer
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Patent number: 10927113Abstract: The present invention relates to a process for preparing a compound of formula [I], said process comprising the steps of: formula [II]+formula [III]?formula [I] (i) forming a reaction mixture comprising (a) a compound of formula [II], (b) a compound of formula [III] and (c) 1,2-propanediol or polyethylene glycol, or a mixture thereof, and optionally (d) a base; (ii) heating said reaction mixture to a temperature of at least about 150° C.Type: GrantFiled: January 25, 2018Date of Patent: February 23, 2021Assignee: Cyclacel LimitedInventors: Benjamin Mark Skead, Robert Westwood, Derek Londesbrough, Julian Scott Northen, Jonathan Charles Christian Atherton
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Publication number: 20190389863Abstract: The present invention relates to a process for preparing a compound of formula [I], said process comprising the steps of: formula [II]+formula [III]->formula [I] (i) forming a reaction mixture comprising (a) a compound of formula [II], (b) a compound of formula [III] and (c) 1,2-propanediol or polyethylene glycol, or a mixture thereof, and optionally (d) a base; (ii) heating said reaction mixture to a temperature of at least about 150° C.Type: ApplicationFiled: January 25, 2018Publication date: December 26, 2019Inventors: Ben SKEAD, Robert WESTWOOD, Derek LONDESBROUGH, Julian NORTHERN, Chris ATHERTON
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Patent number: 8881443Abstract: A lock for a firearm is disclosed. The firearm has a grip safety and a sear engageable to a biased hammer in a cocked position and releasable by a trigger. The lock includes a housing defining a bore within which a mainspring biasing the hammer is revived. A latch is rotatably mounted to the housing and has a grip safety arm and a cam follower, and has a first rotational excursion with the grip safety arm in engagement with and restricting the grip safety to block movement of the trigger, and an opposed second rotational excursion with the grip safety arm in disengagement from the grip safety to unblock depression of the grip safety and movement of the trigger. An actuator is mounted to the housing and cooperatively linked to the latch, and provides motive force for positioning the larch in the first rotational excursion and the second rotational excursion.Type: GrantFiled: January 14, 2013Date of Patent: November 11, 2014Assignee: Intelligun, LLCInventors: William Robert Westwood, Yishai Mendelsohn, Jason Kemmerer
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Patent number: 8884001Abstract: The present invention relates to a process for preparing a compound of formula 682-4, said process comprising the steps of: (i) converting a compound of formula 682-1 into a compound of formula 682-2; (ii) converting said compound of formula 682-2? into a compound of formula 682-3; and (iii) converting said compound of formula 682-3 into a compound of formula 682-4. Further aspects of the invention relate to the use of the above process in the preparation of 2?-cyano-2?-deoxy-N4-palmitoyl-1-?-D-arabmofuranosylcytosine, a pyrimidine nucleoside which is therapeutically useful in the treatment and/or prevention of cancer.Type: GrantFiled: May 8, 2009Date of Patent: November 11, 2014Assignee: Cyclacel LimitedInventors: Gavin Wood, Robert Westwood, Tsuyoshi Murofushi, Eiji Numagami, Takashi Takita
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Patent number: 8497291Abstract: The present invention relates to a pharmaceutical formulation which comprises (i) a capsule, and (ii) a core comprising crystalline 2?-cyano-2?-deoxy-N4-palmitoyl-1-?-D-arabinofuranosylcytosine and a liquid carrier.Type: GrantFiled: December 22, 2006Date of Patent: July 30, 2013Assignee: Cyclacel LimitedInventors: Robert Westwood, Alistair Selkirk
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Patent number: 8404692Abstract: The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts thereof, wherein Z is NR11, NHCO, NHSO2, NHCH2, CH2, CH2CH2, or CH?CH; X is a hydrocarbyl group optionally substituted by one or more R12 groups; R10 and R11 are each independently II or alkyl; R1-R4 are each independently II or (CII2)mR12, where m is O, 1, 2, or 3; each R12 is independently (CH2)aR16, where each R16 is independently selected from O(CH2)bR13, R13, COR13, COOR13, CN, CONR13R14, NR13R14, NR13COR14, SR13, SOR13, SO2R13, NR13SO2R14, SO2OR13, SO2NR13R14, halogen, CF3, and NO2, and wherein each a is 0, 1, 2, or 3 and b is 0, 1, 2, or 3; R13 and R14 are each independently H or (CH2)aR15, where n is 0, 1, 2, or 3; and each R15 is independently selected from alkyl, cycloalkyl, heteroaryl, aralkyl, aryl and heterocycloalkyl, each of which may be optionally substituted by one or more substituents selected from halogen, OH, CN, COO-alkyl, aralkyl, SO2-alkyl, SO2-aryl, COOH, CO-alkyl, CO-aryl, NH2, NH-alkyl, N(Type: GrantFiled: October 9, 2006Date of Patent: March 26, 2013Assignee: Cyclacel LimitedInventors: Stuart Jones, Robert Westwood, Mark Thomas, Janice McLachlan, Kenneth Duncan, Fred Scaerou, Daniella I. Zheleva
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Publication number: 20110224421Abstract: The present invention relates to a process for preparing a compound of formula 682-4, said process comprising the steps of: (i) converting a compound of formula 682-1 into a compound of formula 682-2; (ii) converting said compound of formula 682-2? into a compound of formula 682-3; and (iii) converting said compound of formula 682-3 into a compound of formula 682-4. Further aspects of the invention relate to the use of the above process in the preparation of 2?-cyano-2?-deoxy-N4-palmitoyl-1-?-D-arabmofuranosylcytosine, a pyrimidine nucleoside which is therapeutically useful in the treatment and/or prevention of cancer.Type: ApplicationFiled: May 8, 2009Publication date: September 15, 2011Applicant: CYCLACEL LIMITEDInventors: Gavin Wood, Robert Westwood
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Publication number: 20100035870Abstract: The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts thereof, wherein Z is NR11, NHCO, NHSO2, NHCH2, CH2, CH2CH2, or CH?CH; X is a hydrocarbyl group optionally substituted by one or more R12 groups; R10 and R11 are each independently II or alkyl; R1-R4 are each independently II or (CII2)mR12, where m is O, 1, 2, or 3; each R12 is independently (CH2)aR16, where each R16 is independently selected from O(CH2)bR13, R13, COR13, COOR13, CN, CONR13R14, NR13R14, NR13COR14, SR13, SOR13, SO2R13, NR13SO2R14, SO2OR13, SO2NR13R14, halogen, CF3, and NO2, and wherein each a is 0, 1, 2, or 3 and b is 0, 1, 2, or 3; R13 and R14 are each independently H or (CH2)nR15, where n is 0, 1, 2, or 3; and each R15 is independently selected from alkyl, cycloalkyl, heteroaryl, aralkyl, aryl and heterocycloalkyl, each of which may be optionally substituted by one or more substituents selected from halogen, OH, CN, COO-alkyl, aralkyl, SO2-alkyl, SO2-aryl, COOH, CO— alkyl, CO-aryl, NH2, NH-alkyl, NType: ApplicationFiled: October 9, 2006Publication date: February 11, 2010Applicant: Cyclacel LimitedInventors: Stuart Jones, Robert Westwood, Mark Thomas, Janice McLachlan, Kenneth Duncan, Fred Scaerou, Daniella I. Zheleva
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Publication number: 20090074856Abstract: The present invention relates to a pharmaceutical formulation which comprises (i) a capsule, and (ii) a core comprising crystalline 2?-cyano-2?-deoxy-N4-palmitoyl-1-?-D-arabinofuranosylcytosine and a liquid carrier.Type: ApplicationFiled: December 22, 2006Publication date: March 19, 2009Applicant: Cyclacel LimitedInventors: Robert Westwood, Alastair Selkirk
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Patent number: 5506249Abstract: A compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 is hydrogen or alkyl of 1 to 3 carbon atoms; R.sub.2 is cycloalkyl of 3 to 6 carbon atoms; R.sub.4 is selected from the group consisting of halogen, nitrile, nitro, --SCH.sub.3, -alkylcarbonyl of 1 to 6 carbon atoms, cycloalkylcarbonyl of 3 to 6 carbon atoms, --CX.sub.3, 'WCX.sub.3, --(CH.sub.2).sub.n CX.sub.3, --(CX.sub.2).sub.n CX.sub.3, --W(CX.sub.2).sub.n CX.sub.3 and a --W(CH.sub.2).sub.n CX.sub.3, in which X is halogen, W is oxygen or sulfur, and n is 1, 2 or 3; and R.sub.5 is selected from the group consisting of hydrogen, alkyl of 1 to 3 carbon atoms and cycloalkyl of 3 to 6 carbon atoms; with the proviso that if R.sub.5 is hydrogen, R.sub.4 is not --SCH.sub.3 or --CF.sub.3 and their non-toxic pharmaceutically acceptable salts having anti-prolifera-tive, anti-inflammatory and anti-tumor activity.Type: GrantFiled: December 5, 1994Date of Patent: April 9, 1996Assignee: Roussel UCLAFInventors: Elizabeth A. Kuo, Robert Westwood
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Patent number: 5476866Abstract: A compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 is hydrogen or alkyl of 1 to 3 carbon atoms; R.sub.2 is cycloalkyl of 3 to 6 carbon atoms; R.sub.4 is selected from the group consisting of halogen, nitrile, nitro, --SCH.sub.3, -alkylcarbonyl of 1 to 6 carbon atoms, cycloalkylcarbonyl of 3 to 6 carbon atoms, --CX.sub.3, --WCX.sub.3, --(CH.sub.2).sub.n CX.sub.3, --(CX.sub.2).sub.n CX.sub.3, --W(CX.sub.2).sub.n CX.sub.3 and a --W(CH.sub.2).sub.n CX.sub.3, in which X is halogen, W is oxygen or sulfur, and n is 1, 2 or 3; and R.sub.5 is selected from the group consisting of hydrogen, alkyl of 1 to 3 carbon atoms and cycloalkyl of 3 to 6 carbon atoms; with the proviso that if R.sub.5 is hydrogen, R.sub.4 is not --SCH.sub.3 or --CF.sub.3 and their non-toxic pharmaceutically acceptable salts having anti-prolifera-tive, anti-inflammatory and anti-tumor activity.Type: GrantFiled: August 22, 1994Date of Patent: December 19, 1995Assignee: Roussel UclafInventors: Elizabeth A. Kuo, Robert Westwood
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Patent number: 5371099Abstract: A compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 is hydrogen or alkyl of 1 to 3 carbon atoms, R.sub.2 is alkyl of 1 to 3 carbon atoms or cycloalkyl of 3 to 6 carbon atoms, R.sub.3 is --COOR.sub.6, R.sub.6 is hydrogen or alkyl of 1 to 3 carbon atoms, R.sub.4 is selected from the group consisting of halogen, --CN, --NO.sub.2, --SCH.sub.3, alkylcarbonyl of 1 to 6 alkyl carbon atoms, --CX.sub.3, --WCX.sub.3, --(CH.sub.2).sub.n --CX.sub.3, --(CX.sub.2).sub.n --CX.sub.3, --W--(CX.sub.2).sub.n --CX.sub.3, and --W--(CH.sub.2).sub.n --CX.sub.3, X is halogen, W is --O-- or --S--, n is 1, 2 or 3, R.sub.5 is selected from the group consisting of hydrogen, alkyl of 1 to 3 carbon atoms and cycloalkyl of 3 to 6 carbon atoms and their salts with non-toxic pharmaceutically acceptable bases with the proviso that if R.sub.2 is alkyl of 1 to 3 carbon atoms, R.sub.1 is hydrogen and R.sub.4 is selected from the group consisting of halogen, --CX.sub.3, --(CH.sub.2).sub.n --CX.sub.Type: GrantFiled: April 28, 1993Date of Patent: December 6, 1994Assignee: Roussel-UclafInventors: Robert R. Bartlett, Matharu S. Singh, Elizabeth A. Kuo, Rudolf Schleyerbach, Robert Westwood
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Patent number: 5086170Abstract: A compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen, alkyl and hydroxyalkyl of 1 to 5 carbon atoms and amino, n is an integer from 1 to 3, X and X.sub.1 are individually selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms or taken together with the carbon atom to which they are attached are ##STR2## Y is --O-- or --S--, R.sub.3 is alkyl of 1 to 3 carbon atoms or aryl of 6 to 8 carbon atoms, ##STR3## is selected from the group consisting of ##STR4## R.sub.4 and R.sub.5 are individually aryl unsubstituted or substituted with at least one member of the group consisting of halogen, --NO.sub.2 and alkyl and alkoxy of 1 to 3 carbon atoms and non-toxic, pharmaceutically acceptable salts thereof with acids and bases having cyclooxygenase inhibiting and antibiotic acitvity.Type: GrantFiled: December 24, 1990Date of Patent: February 4, 1992Assignee: Roussel UclafInventors: Abdul B. N. Luheshi, Robert K. Smalley, Peter D. Kennewell, Robert Westwood
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Patent number: 5059596Abstract: A compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen, alkyl and hydroxyalkyl of 1 to 5 carbon atoms and amino, n is an integer from 1 to 3, X and X.sub.1 are individually selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms or taken together with the carbon atom to which they are attached are >C.dbd.O Y is --O-- or --S--, R.sub.3 is alkyl of 1 to 3 carbon atoms or aryl of 6 to 8 carbon atoms, ##STR2## is selected from the group consisting of ##STR3## R.sub.4 and R.sub.5 are individually aryl unsubstituted or substituted with at least one member of the group consisting of halogen, --NO.sub.2 and alkyl and alkoxy of 1 to 3 carbon atoms and non-toxic, pharmaceutically acceptable salts thereof with acids and bases having cyclooxygenase inhibiting and antibiotic activity.Type: GrantFiled: January 16, 1990Date of Patent: October 22, 1991Assignee: Roussel UclafInventors: Abdul B. N. Luheshi, Robert K. Smalley, Peter D. Kennewell, Robert Westwood
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Patent number: 4847268Abstract: A compound selected from the group consisting of 8-phenylthio-tetrahydroquinolines of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen, halogen, alkyl of 1 to 6 carbon atoms optionally substituted with hydroxy, alkoxy of 1 to 6 carbon atoms, alkanoyloxy of 1 to 6 carbon atoms, alkoxycarbonyl of 2 to 6 carbon atoms, --OH, --NO.sub.2, --NH.sub.2, --COOH, --CN and aminosulfonyl or when R.sub.1 and R.sub.2 are on adjacent carbon atoms form with the said carbon atoms phenyl and their non-toxic, pharmaceutically acceptable acid addition salts having anti-allergic activity.Type: GrantFiled: June 16, 1987Date of Patent: July 11, 1989Assignee: Roussel UclafInventors: Stephen Clements-Jewery, Peter D. Kennewell, Robert Westwood
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Patent number: 4794122Abstract: A compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are individually selected from the group consisting of hydrogen, halogen and alkyl and alkoxy of 1 to 6 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having anti-allergic and anti-inflammatory properties.Type: GrantFiled: June 3, 1987Date of Patent: December 27, 1988Assignee: Roussel UclafInventors: Stephen Clements-Jewery, Peter D. Kennewell, Robert Westwood
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Patent number: 4751233Abstract: Novel 8-thiotetrahydroquinolines of the formula ##STR1## wherein X is selected from the group consisting of ##STR2## Alk is alkyl of 1 to 6 carbon atoms, R.sub.1 and R.sub.2 are Alk individually selected from the group consisting of hydrogen and aryl or taken together with the carbon atoms to which they are attached form a phenyl optionally substituted with at least one member of the group consisting of alkyl, alkoxy and alkylthio of 1 to 6 carbon atoms, halogen, ##STR3## and Alk' is alkyl of 1 to 6 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having antiallergic activity and their preparation.Type: GrantFiled: February 26, 1986Date of Patent: June 14, 1988Assignee: Roussel UclafInventors: Stephen Clements-Jewery, Peter D. Kennewell, Robert Westwood
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Patent number: 4510143Abstract: Novel pyrimidines of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of --OH, cation of metals and organic bases, alkoxy of 1 to 5 carbon atoms, hydrazino and 1H-tetrazol-5-yl-amino, A is selected from the group consisting of ##STR2## R.sub.2 is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms and R.sub.3 and R.sub.4 are individually selected from the group consisting of hydrogen, halogen and alkyl and alkoxy of 1 to 5 carbon atoms with the proviso that when R.sub.1 is alkoxy of 1 to 5 carbon atoms, R.sub.2 is not hydrogen and their non-toxic, pharmaceutically acceptable acid addition salts having anti-allergic properties.Type: GrantFiled: February 10, 1983Date of Patent: April 9, 1985Assignee: Roussel UclafInventors: Robert Westwood, Peter Miller, Ian R. Ager, David P. Kay
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Patent number: 4472400Abstract: Novel triazoloquinazolones of the formula ##STR1## wherein R and R' are individually selected from the group consisting of hydrogen, halogen, nitro and alkyl and alkoxy of 1 to 3 carbon atoms, Y is selected from the group consisting of alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 4 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, aryl of 6 to 8 carbon atoms and aralkyl of 7 to 8 carbon atoms, B is an alkylene of 1 to 3 carbon atoms, X is selected from the group consisting of ##STR2## R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, aryl of 6 to 8 carbon atoms, aralkyl of 7 to 8 carbon atoms, aminoalkyl of 2 to 4 carbon atoms, mono- and dialkylaminoalkyl with each alkyl having 2 to 4 carbon atoms, piperidinoalkyl of 1 to 4 alkyl carbon atoms, morpholinoalkyl of 1 to 4 alkyl carbon atoms and piperazinylalkyl of 1 to 4 alkyl carbon atoms or R.sub.1 and R.sub.Type: GrantFiled: September 21, 1982Date of Patent: September 18, 1984Assignee: Roussel UclafInventors: Wilfred R. Tully, Robert Westwood, David A. Rowlands, Stephen Clements-Jewery