Patents by Inventor Robert Yuan
Robert Yuan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240124934Abstract: The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DAS-59122-7 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.Type: ApplicationFiled: December 7, 2023Publication date: April 18, 2024Inventors: James Wayne Bing, Robert F. Cressman, Manju Gupta, Salim M. Hakimi, David Hondred, Todd L. Krone, Mary E. Hartnett Locke, Abigail K. Luckring, Sandra E. Meyer, Daniel Moellenbeck, Kenneth Edwin Narva, Paul D. Olson, Craig D. Sanders, Jimei Wang, Jian Zhang, Gan-Yuan Zhong
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Publication number: 20240111101Abstract: The present disclosure relates to laser treatment of an optical fiber to secure the optical fiber within a ferrule bore. In particular, the laser treatment modifies the physical structure of the optical fiber to aid in securing the optical fiber within the ferrule bore and to correct core-to-ferrule eccentricity errors.Type: ApplicationFiled: September 1, 2023Publication date: April 4, 2024Inventors: Robert Bruce Elkins, II, Ming-Jun Li, Ying Liu, Lei Yuan
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Patent number: 11947802Abstract: The present disclosure relates to utilizing a buffer management system to efficiently manage and deallocate memory buffers utilized by multiple processing roles on computer hardware devices. For example, the buffer management system utilizes distributed decentralized memory buffer monitoring in connection with augmented buffer pointers to deallocate memory buffers accurately and efficiently. In this manner, the buffer management system provides an efficient approach for multiple processing roles to consume source data stored in a memory buffer and to deallocate the buffer only after all roles have finished using it.Type: GrantFiled: September 13, 2022Date of Patent: April 2, 2024Assignee: Microsoft Technology Licensing, LLCInventors: Yi Yuan, Narayanan Ravichandran, Robert Groza, Jr., Yevgeny Yankilevich, Hari Daas Angepat
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Patent number: 11933941Abstract: The invention is related to contact lenses that not only comprise the much desired water gradient structural configurations, but also have a minimized uptakes of polycationic antimicrobials and a long-lasting surface hydrophilicity and wettability even after going through a 30-days lens care regime. Because of the water gradient structural configuration and a relatively-thick, extremely-soft and water-rich hydrogel surface layer, a contact lens of the invention can provide superior wearing comfort. Further, a contact lens of the invention is compatible with multipurpose lens care solutions present in the market and can endure the harsh lens care handling conditions (e.g., digital rubbings, accidental inversion of contact lenses, etc.) encountered in a daily lens care regime. As such, they are suitable to be used as weekly- or monthly-disposable water gradient contact lenses.Type: GrantFiled: January 11, 2022Date of Patent: March 19, 2024Assignee: Alcon Inc.Inventors: Yongxing Qiu, John Dallas Pruitt, Newton T. Samuel, Chung-Yuan Chiang, Robert Carey Tucker, Yuan Chang, Ethan Leveillee
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Publication number: 20240086072Abstract: The present disclosure relates to utilizing a buffer management system to efficiently manage and deallocate memory buffers utilized by multiple processing roles on computer hardware devices. For example, the buffer management system utilizes distributed decentralized memory buffer monitoring in connection with augmented buffer pointers to deallocate memory buffers accurately and efficiently. In this manner, the buffer management system provides an efficient approach for multiple processing roles to consume source data stored in a memory buffer and to deallocate the buffer only after all roles have finished using it.Type: ApplicationFiled: September 13, 2022Publication date: March 14, 2024Inventors: Yi YUAN, Narayanan RAVICHANDRAN, Robert GROZA, JR., Yevgeny YANKILEVICH, Hari Daas ANGEPAT
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Patent number: 11919194Abstract: A method of plugging channels of a honeycomb body and a honeycomb body including plugged channels. The method includes applying a shear force to a plugging mixture including a plurality of inorganic particles, clay, and a liquid vehicle to alter the viscosity of the plugging mixture from a first viscosity prior to the vibrating to a second viscosity which is less than the first viscosity. A honeycomb body is placed into contact with the plugging mixture such that a portion of the plugging mixture having the second viscosity flows into the plurality of channels. Application of the shear force is stopped or reduced to increase the viscosity of the portion of the plugging mixture in the plurality of channels to greater than the first viscosity.Type: GrantFiled: January 29, 2021Date of Patent: March 5, 2024Assignee: Corning IncorporatedInventors: Keith Norman Bubb, Theresa Chang, Joseph Henry Citriniti, Kevin Eugene Elliott, Xinyuan Liu, Robert John Locker, Prashanth Abraham Vanniamparambil, Kevin Lee Wasson, Shu Yuan
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Patent number: 11846281Abstract: A delivery system for a sensor chip includes a plurality of selectable ports and a two-way pump port selectively connectable to each of the selectable ports. The two-way pump port is configured to allow material to be drawn or delivered from or to the two-way pump port. The delivery system also includes a chamber and a bypass waste channel that is selectively connectable to the two-way pump port. The plurality of selectable ports includes a selectable chamber port connected to the chamber and the chamber has a chamber waste exit. Material may selectively flow through the chamber to a waste collection via the chamber waste exit or flow to the waste collection via the bypass waste channel that bypasses the chamber waste exit.Type: GrantFiled: November 12, 2020Date of Patent: December 19, 2023Assignee: Roche Sequencing Solutions, Inc.Inventor: Robert A Yuan
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Publication number: 20230280308Abstract: A nanopore based sequencing system includes a plurality of nanopore sensors. Each nanopore sensor has a portion for receiving a fluid. The nanopore based sequencing system includes a fluid chamber configured to guide the fluid over the plurality of nanopore sensors and an inlet configured to deliver the fluid into the fluid chamber. At least a portion of the fluid chamber is made of a material that has been molded around at least a portion of an electrode.Type: ApplicationFiled: May 12, 2023Publication date: September 7, 2023Inventors: Edward Liu, Kenneth M. Stothers, Markus Wallgren, Janusz B. Wojtowicz, Robert A. Yuan
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Patent number: 11686706Abstract: A nanopore based sequencing system includes a plurality of nanopore sensors. Each nanopore sensor has a portion for receiving a fluid. The nanopore based sequencing system includes a fluid chamber configured to guide the fluid over the plurality of nanopore sensors and an inlet configured to deliver the fluid into the fluid chamber. At least a portion of the fluid chamber is made of a material that has been molded around at least a portion of an electrode.Type: GrantFiled: July 15, 2020Date of Patent: June 27, 2023Assignee: Roche Sequencing Solutions, Inc.Inventors: Edward Liu, Kenneth M. Stothers, Markus Wallgren, Janusz B. Wojtowicz, Robert A. Yuan
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Publication number: 20220299472Abstract: A nanopore based sequencing chip package is disclosed. The nanopore based sequencing chip package includes a reservoir defined by a plurality of surfaces. The chip package includes a nanopore cell array comprising a plurality of nanopore sensor cells enclosed by the reservoir. Each nanopore sensor cell has a working electrode. At least one surface of the reservoir is configured to be in contact with a conducting fluid when the conducting fluid is flowing through the reservoir. The chip package further includes a counter electrode disposed on the at least one surface of the reservoir.Type: ApplicationFiled: June 2, 2022Publication date: September 22, 2022Inventors: J. William Maney, JR., David Bruce Robinson, Markus Wallgren, Robert A. Yuan
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Publication number: 20220291192Abstract: A consumable device used in a nanopore based sequencing system can include a nanopore chip, a flow cell with one or more flow channels, and a flow cell cover. A fluidic interface can be used to deliver fluid to the flow cell. The fluid interface can include a flow cell boss and the flow cell cover can include a receptacle for receiving the flow cell boss. A dispense tip can be used to introduce fluid into the flow cell through the flow cell boss.Type: ApplicationFiled: September 22, 2020Publication date: September 15, 2022Inventors: Matthew DiPietro, Damion Engelbart, Andrew Liu, William Nielsen, Janusz B. Wojtowicz, Robert A. Yuan
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Publication number: 20210115915Abstract: A delivery system for a sensor chip includes a plurality of selectable ports and a two-way pump port selectively connectable to each of the selectable ports. The two-way pump port is configured to allow material to be drawn or delivered from or to the two-way pump port. The delivery system also includes a chamber and a bypass waste channel that is selectively connectable to the two-way pump port. The plurality of selectable ports includes a selectable chamber port connected to the chamber and the chamber has a chamber waste exit. Material may selectively flow through the chamber to a waste collection via the chamber waste exit or flow to the waste collection via the bypass waste channel that bypasses the chamber waste exit.Type: ApplicationFiled: November 12, 2020Publication date: April 22, 2021Inventor: Robert A. Yuan
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Patent number: 10837440Abstract: A delivery system for a sensor chip includes a plurality of selectable ports and a two-way pump port selectively connectable to each of the selectable ports. The two-way pump port is configured to allow material to be drawn or delivered from or to the two-way pump port. The delivery system also includes a chamber and a bypass waste channel that is selectively connectable to the two-way pump port. The plurality of selectable ports includes a selectable chamber port connected to the chamber and the chamber has a chamber waste exit. Material may selectively flow through the chamber to a waste collection via the chamber waste exit or flow to the waste collection via the bypass waste channel that bypasses the chamber waste exit.Type: GrantFiled: April 17, 2018Date of Patent: November 17, 2020Assignee: Roche Sequencing Solutions, Inc.Inventor: Robert A. Yuan
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Publication number: 20200348261Abstract: A nanopore based sequencing system includes a plurality of nanopore sensors. Each nanopore sensor has a portion for receiving a fluid. The nanopore based sequencing system includes a fluid chamber configured to guide the fluid over the plurality of nanopore sensors and an inlet configured to deliver the fluid into the fluid chamber. At least a portion of the fluid chamber is made of a material that has been molded around at least a portion of an electrode.Type: ApplicationFiled: July 15, 2020Publication date: November 5, 2020Inventors: Edward Liu, Kenneth M. Stothers, Markus Wallgren, Janusz B. Wojtowicz, Robert A. Yuan
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Patent number: 10718737Abstract: A nanopore based sequencing system includes a plurality of nanopore sensors. Each nanopore sensor has a portion for receiving a fluid. The nanopore based sequencing system includes a fluid chamber configured to guide the fluid over the plurality of nanopore sensors and an inlet configured to deliver the fluid into the fluid chamber. At least a portion of the fluid chamber is made of a material that has been molded around at least a portion of an electrode.Type: GrantFiled: January 19, 2017Date of Patent: July 21, 2020Assignee: Roche Sequencing Solutions, Inc.Inventors: Robert A. Yuan, Janusz B. Wojtowicz, Edward Liu, Kenneth M. Stothers, Markus Wallgren
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Patent number: 10371664Abstract: A nanopore cell includes a titanium nitride (TiN) counter electrode configured to be at a first electric potential. The nanopore cell also include a working electrode configured to be at a second electric potential and an insulating wall. The insulating wall and the working electrode form at least a portion of a well configured to contain an electrolyte at a voltage that is at least a portion of an electric potential difference between the first electric potential of the titanium nitride counter electrode and the second electric potential of the working electrode.Type: GrantFiled: January 19, 2017Date of Patent: August 6, 2019Assignee: Roche Molecular Systems, Inc.Inventors: Markus Wallgren, Janusz B. Wójtowicz, Robert A. Yuan, John Foster, Jason Komadina
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Patent number: 10273536Abstract: A biochip for molecular detection and sensing is disclosed. The biochip includes a substrate. The biochip includes a plurality of discrete sites formed on the substrate having a density of greater than five hundred wells per square millimeter. Each discrete site includes sidewalls disposed on the substrate to form a well. Each discrete site includes an electrode disposed at the bottom of the well. In some embodiments, the wells are formed such that cross-talk between the wells is reduced. In some embodiments, the electrodes disposed at the bottom of the wells are organized into groups of electrodes, wherein each group of electrodes shares a common counter electrode. In some embodiments, the electrode disposed at the bottom of the well has a dedicated counter electrode. In some embodiments, surfaces of the sidewalls are silanized such that the surfaces facilitate the forming of a membrane in or adjacent to the well.Type: GrantFiled: March 10, 2016Date of Patent: April 30, 2019Assignees: GENIA TECHNOLOGIES, INC., ROCHE MOLECULAR SYSTEMS, INC.Inventors: Randall W. Davis, Edward Shian Liu, Eric Takeshi Harada, Anne Aguirre, Andrew Trans, James Pollard, Cynthia Cech, Hui Tian, Robert Yuan, John Foster, Roger Chen
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Patent number: 10234446Abstract: A nanopore based sequencing system is disclosed. The system includes a plurality of nanopore sensors, each nanopore sensor having a top portion for receiving a fluid. The system further includes an inlet delivering the fluid into the nanopore based sequencing system and an outlet delivering the fluid out of the nanopore based sequencing system. The system includes a fluid chamber that comprises one or more fluid flow channels above top portions of the nanopore sensors; wherein the fluid chamber includes at least one divider that limits the width of the one or more fluid flow channels. In some embodiments, the at least one divider limits the width of the one or more fluid flow channel based on whether the surface tension and adhesive forces between the fluid and the fluid flow channel surfaces are sufficient to prevent the fluid from collapsing within the fluid flow channel.Type: GrantFiled: September 8, 2017Date of Patent: March 19, 2019Assignee: Genia Technologies, Inc.Inventor: Robert A. Yuan
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Publication number: 20180306181Abstract: A delivery system for a sensor chip includes a plurality of selectable ports and a two-way pump port selectively connectable to each of the selectable ports. The two-way pump port is configured to allow material to be drawn or delivered from or to the two-way pump port. The delivery system also includes a chamber and a bypass waste channel that is selectively connectable to the two-way pump port. The plurality of selectable ports includes a selectable chamber port connected to the chamber and the chamber has a chamber waste exit. Material may selectively flow through the chamber to a waste collection via the chamber waste exit or flow to the waste collection via the bypass waste channel that bypasses the chamber waste exit.Type: ApplicationFiled: April 17, 2018Publication date: October 25, 2018Inventor: Robert A. Yuan
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Patent number: 10008037Abstract: An augmented reality environment allows interaction between virtual and real objects. By monitoring user actions with the augmented reality environment various functions are provided to users. Users may buy or sell items with a gesture, check inventory of objects in the augmented reality environment, view advertisements, and so forth.Type: GrantFiled: June 10, 2011Date of Patent: June 26, 2018Assignee: Amazon Technologies, Inc.Inventors: William Spencer Worley, III, Edward Dietz Crump, Robert A. Yuan, Christopher Coley, Colter E. Cederlof