Patents by Inventor Roberto Brescello

Roberto Brescello has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of detecting polymorphs using synchrotron radiation
    Patent number: 9513237
    Abstract: A method of detecting polymorphs using X-ray produced by a synchrotron source is described. In particular, the method allows to detect particular polymorphs present in small amounts in mixtures of polymorphic compounds present in a prevailing amount. The method offers a powerful resolution of mixtures of polymorph and finds application particularly in the pharmaceutical field.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: December 6, 2016
    Assignee: ZETACUBE S.R.L.
    Inventors: Roberto Brescello, Livius Cotarca, Anna Smaniotto, Massimo Verzini, Maurizio Polentarutti, Giorgio Bais, Jasper Rikkert Plaisier
  • Process for preparing enantiomerically enriched oxamides
    Patent number: 9481686
    Abstract: The present invention relates to a chiral oxamide of formula (I) useful as an intermediate in the preparation of dorzolamide, and to the preparation thereof. The invention also relates to the preparation of dorzolamide, to the hydrochloride salt thereof, and to the active ingredient contained in a drug useful in the treatment of glaucoma, by means of the intermediate of formula (I).
    Type: Grant
    Filed: June 28, 2013
    Date of Patent: November 1, 2016
    Assignee: ZACH SYSTEM S.P.A.
    Inventors: Raffaella Volpicelli, Antonio Nardi, Mauro Andretto, Ilaria Munari, Roberto Brescello, Anna Smaniotto, Livius Cotarca, Massimo Verzini
  • Process for Preparing Enantiomerically Enriched Oxamides
    Publication number: 20150191485
    Abstract: The present invention relates to a chiral oxamide of formula (I) useful as an intermediate in the preparation of dorzolamide, and to the preparation thereof. The invention also relates to the preparation of dorzolamide, to the hydrochloride salt thereof, and to the active ingredient contained in a drug useful in the treatment of glaucoma, by means of the intermediate of formula (I).
    Type: Application
    Filed: June 28, 2013
    Publication date: July 9, 2015
    Inventors: Raffaella Volpicelli, Antonio Nardi, Mauro Andretto, Ilaria Munari, Roberto Brescello, Anna Smaniotto, Livius Cotarca, Massimo Verzini
  • METHOD OF DETECTING POLYMORPHS USING SYNCHROTRON RADIATION
    Publication number: 20140185767
    Abstract: A method of detecting polymorphs using X-ray produced by a synchrotron source is described. In particular, the method allows to detect particular polymorphs present in small amounts in mixtures of polymorphic compounds present in a prevailing amount. The method offers a powerful resolution of mixtures of polymorph and finds application particularly in the pharmaceutical field.
    Type: Application
    Filed: May 16, 2012
    Publication date: July 3, 2014
    Applicant: Zach System S.P.A.
    Inventors: Roberto Brescello, Livius Cotarca, Anna Smaniotta, Massimo Verzini, Maurizio Polentarutti, Giorgio Bais, Jasper Rikkert Plaisier
  • Methods of preparing polymorphic form A of bazedoxifene acetate
    Patent number: 8618284
    Abstract: The present invention relates to methods of preparing polymorphic Form A of bazedoxifene acetate and polymorphic Form A prepared by such methods.
    Type: Grant
    Filed: April 23, 2012
    Date of Patent: December 31, 2013
    Assignee: Wyeth LLC
    Inventors: Paolo Andreella, Giuseppe Barreca, Francesco Tasinato, Massimo Verzini, Marco Demo, Fabio Bassan, Vincenzo Cannata, Giorgio Soriato, Roberto Brescello, Pietro Allegrini, Livius Cotarca
  • METHODS OF PREPARING POLYMORPHIC FORM A OF BAZEDOXIFENE ACETATE
    Publication number: 20130018184
    Abstract: The present invention relates to methods of preparing polymorphic Form A of bazedoxifene acetate and polymorphic Form A prepared by such methods.
    Type: Application
    Filed: April 23, 2012
    Publication date: January 17, 2013
    Applicant: Wyeth LLC
    Inventors: Paolo Andreella, Giuseppe Barreca, Francesco Tasinato, Massimo Verzini, Marco Demo, Fabio Bassan, Vincenzo Cannata, Giorgio Soriato, Roberto Brescello, Pietro Allegrini, Livius Cotarca
  • Methods of preparing polymorphic form A of bazedoxifene acetate
    Patent number: 8183367
    Abstract: The present invention relates to methods of preparing polymorphic Form A of bazedoxifene acetate and polymorphic Form A prepared by such methods.
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: May 22, 2012
    Assignee: Wyeth LLC
    Inventors: Paolo Andreella, Giuseppe Barreca, Francesco Tasinato, Massimo Verzini, Marco Demo, Fabio Bassan, Vincenzo Cannata, Giorgio Soriato, Roberto Brescello, Pietro Allegrini, Livius Cotarca
  • Polymorphic Form D of bazedoxifene acetate and methods of preparing same
    Patent number: 8063041
    Abstract: The present disclosure relates to polymorphic Form D of bazedoxifene acetate, pharmaceutical compositions and methods of treatment using the same, and methods of preparing the same.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: November 22, 2011
    Assignee: Wyeth LLC
    Inventors: Paolo Andreella, Roberto Brescello, Ivan Michieletto, Mauro Maffini, Nicola Catozzi, Andrea Nicoli, Paolo Fornasari, Massimo Verzini, Livius Cotarca, Franco Brazzarola
  • Crystalline forms of macrolide compounds endowed with antiinflammatory activity
    Patent number: 7956042
    Abstract: The present invention relates to macrolide compounds endowed with antiinflammatory activity and more particularly relates to new stable crystalline forms of a macrolide derivative with antiinflammatory activity, processes for the preparation of such forms, pharmaceutical compositions containing them as active ingredient and the use of said crystalline forms for the treatment of inflammatory diseases.
    Type: Grant
    Filed: July 5, 2006
    Date of Patent: June 7, 2011
    Assignee: Zambon S.p.A.
    Inventors: Paolo Maragni, Dario Braga, Roberto Brescello, Livius Cotarca, Alessandro Di Maria, Franco Massaccesi, Elisa Melotto, Ivan Michieletto, Gabriele Morazzoni, Mauro Napoletano, Franco Pellacini, Angelo Restelli, Massimo Verzini
  • PROCESS FOR THE PREPARATION OF CLOPIDOGREL HYDROGEN SULFATE CRYSTALLINE FORM I
    Publication number: 20110118467
    Abstract: The present invention relates to a process for the preparation of clopidogrel and, more particularly, to an improved process for the preparation of clopidogrel hydrogen sulfate crystalline Form I by addition of dilute sulfuric acid to a solution of clopidogrel free base in butyl acetate.
    Type: Application
    Filed: June 11, 2009
    Publication date: May 19, 2011
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Giorgio Soriato, Roberto Brescello, Daniele Urbani, Livius Cotarca
  • POLYMORPHIC FORM D OF BAZEDOXIFENE ACETATE AND METHODS OF PREPARING SAME
    Publication number: 20110021504
    Abstract: The present disclosure relates to polymorphic Form D of bazedoxifene acetate, pharmaceutical compositions and methods of treatment using the same, and methods of preparing the same.
    Type: Application
    Filed: June 22, 2010
    Publication date: January 27, 2011
    Inventors: Paolo Andreella, Roberto Brescello, Ivan Michieletto, Mauro Maffini, Nicola Catozzi, Andrea Nicoli, Paolo Fornasari, Massimo Verzini, Livius Cotarca, Franco Brazzarola
  • Crystalline polymorph of bazedoxifene acetate
    Patent number: 7683052
    Abstract: The present invention is directed to a crystalline polymorph of bazedoxifene acetate, compositions containing the same, preparations thereof, and uses thereof.
    Type: Grant
    Filed: April 6, 2005
    Date of Patent: March 23, 2010
    Assignee: Wyeth
    Inventors: Kadum A. Ali, Pietro Allegrini, Aldo Belli, Roberto Brescello, Vincenzo Cannata, Malama K. Chibwe, Livius Cotarca, Shridhar G. Gangolli, Carl E. Longfellow, Giorgio Soriato, Massimo Verzini
  • AMORPHOUS POLYMORPH OF BAZEDOXIFENE ACETATE
    Publication number: 20100016290
    Abstract: The invention provides a novel polymorphic form C of bazedoxifene acetate, methods of preparing the polymorphic form, and compositions and methods of treatment using the polymorphic form.
    Type: Application
    Filed: February 11, 2009
    Publication date: January 21, 2010
    Inventors: Livius Cotarca, Ivan Michieletto, Paolo Maragni, Roberto Brescello
  • METHODS OF PREPARING POLYMORPHIC FORM A OF BAZEDOXIFENE ACETATE
    Publication number: 20100016581
    Abstract: The present invention relates to methods of preparing polymorphic Form A of bazedoxifene acetate and polymorphic Form A prepared by such methods.
    Type: Application
    Filed: February 11, 2009
    Publication date: January 21, 2010
    Applicant: Wyeth
    Inventors: Paolo Andreella, Giuseppe Barreca, Francesco Tasinato, Massimo Verzini, Marco Demo, Fabio Bassan, Vincenzo Cannata, Giorgio Soriato, Roberto Brescello, Pietro Allegrini, Livius Cotarca
  • METHODS OF CONVERTING POLYMORPHIC FORM B OF BAZEDOXIFENE ACETATE TO POLYMORPHIC FORM A OF BAZEDOXIFENE ACETATE
    Publication number: 20100016582
    Abstract: The present invention relates to methods of preparing polymorphic Form A of bazedoxifene acetate and polymorphic Form A prepared by such methods.
    Type: Application
    Filed: February 11, 2009
    Publication date: January 21, 2010
    Applicant: Wyeth
    Inventors: Giorgio SORIATO, Livius COTARCA, Roberto BRESCELLO
  • CRYSTALLINE FORMS OF MACROLIDE COMPOUNDS ENDOWED WITH ANTIINFLAMMATORY ACTIVITY
    Publication number: 20090018089
    Abstract: the present invention relates to macrolide compounds endowed with antiinflammatory activity and more particularly relates to new stable crystalline forms of a macrolide derivative with antiinflammatory activity, processes for the preparation of such forms, pharmaceutical compositions containing them as active ingredient and the use of said crystalline forms for the treatment of inflammatory diseases.
    Type: Application
    Filed: July 5, 2006
    Publication date: January 15, 2009
    Applicant: ZAMBON S.p.A.
    Inventors: Paolo Maragni, Dario Braga, Roberto Brescello, Livius Cotarca, Alessandro Di Maria, Franco Massaccesi, Elisa Melotto, Ivan Michieletto, Gabriele Morazzoni, Mauro Napoletano, Franco Pellacini, Angelo Restelli, Massimo Verzini
  • Crystalline polymorph of bazedoxifene acetate
    Publication number: 20050250762
    Abstract: The present invention is directed to a crystalline polymorph of bazedoxifene acetate, compositions containing the same, preparations thereof, and uses thereof.
    Type: Application
    Filed: April 6, 2005
    Publication date: November 10, 2005
    Applicant: Wyeth
    Inventors: Kadum Ali, Pietro Allegrini, Aldo Belli, Roberto Brescello, Vincenzo Cannata, Malama Chibwe, Livius Cotarca, Shridhar Gangolli, Carl Longfellow, Giorgio Soriato, Massimo Verzini