Abstract: The present invention relates to processes for obtaining a highly concentrated antibody solution. In particular, to processes for obtaining a highly concentrated therapeutic antibody solution that may be used for highly concentrated therapeutic antibody formulations, e.g. suitable for subcutaneous administration.

Abstract: The present invention relates to a process and apparatus for purifying a molecule of interest from a heterogeneous clarified fluid mixture. The apparatus of the invention generally comprises a continuous perfusion fermentation system, a continuous particle removal system integrated with the perfusion fermentation system; and a continuous purification system integrated with the particle removal system, which is maintained under sterile conditions. The process comprises filtering a heterogeneous clarified fluid mixture by continuous ultrafiltration at a specific flow rate below the transition point of the molecule of interest in the pressure-dependent region of the flux versus TMP curve, wherein the specific flow rate is maintained substantially constant throughout the continuous ultrafiltration.

Abstract: The present invention relates to a process and apparatus for purifying a molecule of interest from a heterogeneous clarified fluid mixture. The apparatus of the invention generally comprises a continuous perfusion fermentation system, a continuous particle removal system integrated with the perfusion fermentation system; and a continuous purification system integrated with the particle removal system, which is maintained under sterile conditions. The process comprises filtering a heterogeneous clarified fluid mixture by continuous ultrafiltration at a specific flow rate below the transition point of the molecule of interest in the pressure-dependent region of the flux versus TMP curve, wherein the specific flow rate is maintained substantially constant throughout the continuous ultrafiltration.

Abstract: A baffle system for guiding fuel stored within a fuel tank is disclosed. The baffle system may include first and second baffle walls. Each of the first and second baffle walls may be formed from inner, intermediate, and outer portions. Each inner portion may extend from the respective intermediate portion. Each outer portion may extend from the respective intermediate portion, with an angle at a junction of the outer and intermediate portions being between approximately 120 degrees and 150 degrees. The first and second baffles walls may form a partially-closed volume with the first and second inner and intermediate portions, where the partially-closed volume may be configured to retain fuel guided into the volume by the first and second outer portions.

Abstract: A baffle system for guiding fuel stored within a fuel tank is disclosed. The baffle system may include first and second baffle walls. Each of the first and second baffle walls may be formed from inner, intermediate, and outer portions. Each inner portion may extend from the respective intermediate portion. Each outer portion may extend from the respective intermediate portion, with an angle at a junction of the outer and intermediate portions being between approximately 120 degrees and 150 degrees. The first and second baffles walls may form a partially-closed volume with the first and second inner and intermediate portions, where the partially-closed volume may be configured to retain fuel guided into the volume by the first and second outer portions.

Abstract: The present invention relates to a process and apparatus for purifying a molecule of interest from a heterogeneous clarified fluid mixture. The apparatus of the invention generally comprises a continuous perfusion fermentation system, a continuous particle removal system integrated with the perfusion fermentation system; and a continuous purification system integrated with the particle removal system, which is maintained under sterile conditions. The process comprises filtering a heterogeneous clarified fluid mixture by continuous ultrafiltration at a specific flow rate below the transition point of the molecule of interest in the pressure-dependent region of the flux versus TMP curve, wherein the specific flow rate is maintained substantially constant throughout the continuous ultrafiltration.