Patents by Inventor Roberto Pellicciari

Roberto Pellicciari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Steroids as Agonists for FXR
    Publication number: 20160152657
    Abstract: The invention relates to compounds of formula (I): wherein R is ethyl, propyl or allyl, and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof. The compounds of formula (I) are useful as FXR agonists.
    Type: Application
    Filed: February 5, 2016
    Publication date: June 2, 2016
    Inventor: Roberto Pellicciari
  • TGR5 Modulators and Methods of Use Thereof
    Publication number: 20160096862
    Abstract: The invention relates to compounds of Formula A: or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof. The compounds of Formula A are TGR5 modulators useful for the treatment of various diseases, including obesity, insulin sensitivity, inflammation, cholestasis, and bile desaturation.
    Type: Application
    Filed: December 11, 2015
    Publication date: April 7, 2016
    Inventor: Roberto Pellicciari
  • INHIBITORS OF ALPHA-AMINO-BETA-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE
    Publication number: 20160060226
    Abstract: The present disclosure discloses compounds capable of modulating the activity of ?-amino-?-carboxymuconic acid semialdehyde decarboxylase (ACMSD), which are useful for the prevention and/or the treatment of diseases and disorders associated with defects in NAD+ biosynthesis, e.g., metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, kidney diseases, and diseases associated with ageing. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament.
    Type: Application
    Filed: August 28, 2015
    Publication date: March 3, 2016
    Inventors: Roberto Pellicciari, Johan Auwerx, Nadia Raffaelli
  • TGR5 MODULATORS AND METHODS OF USE THEREOF
    Publication number: 20160052956
    Abstract: The invention relates to compounds of Formula A: or a salt, solvate, or hydrate thereof. The compounds of formula A are TGR5 modulators useful for the treatment of disease.
    Type: Application
    Filed: August 1, 2014
    Publication date: February 25, 2016
    Inventor: Roberto Pellicciari
  • Thiazolyl- and oxazolyl-isoquinolinones and methods for using them
    Patent number: 9265769
    Abstract: The present invention relates to substituted thiazolyl- and oxazolyl-isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thiazolyl- and oxazolyl-isoquinolinones and to their use in treating various diseases and disorders.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: February 23, 2016
    Inventors: Roberto Pellicciari, Flavio Moroni
  • TGR5 modulators and methods of use thereof
    Patent number: 9243027
    Abstract: The invention relates to compounds of Formula A: or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof. The compounds of Formula A are TGR5 modulators useful for the treatment of various diseases, including obesity, insulin sensitivity, inflammation, cholestasis, and bile desaturation.
    Type: Grant
    Filed: April 1, 2013
    Date of Patent: January 26, 2016
    Assignee: INTERCEPT PHARMACEUTICALS, INC.
    Inventor: Roberto Pellicciari
  • Bile Acid Derivatives as FXR Ligands for the Prevention or Treatment of FXR-Mediated Diseases or Conditions
    Publication number: 20150359805
    Abstract: The present invention relates to compounds of formula (I): wherein R is hydrogen or alpha-hydroxy, the hydroxyl group in position 7 is in the alpha or beta position; and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof.
    Type: Application
    Filed: June 18, 2015
    Publication date: December 17, 2015
    Inventors: Roberto Pellicciari, Stefano Fiorucci, Mark Pruzanski
  • PROCESS FOR PREPARING BILE ACID DERIVATIVES
    Publication number: 20150291653
    Abstract: The present invention relates to processes for preparing compounds of formula I: or a pharmaceutically acceptable salt or solvate thereof.
    Type: Application
    Filed: October 25, 2013
    Publication date: October 15, 2015
    Applicant: Intercept Pharmaceuticals, Inc.
    Inventors: Roberto Pellicciari, Antimo Gioiello
  • Bile acid derivatives as FXR ligands for the prevention or treatment of FXR-mediated diseases or conditions
    Patent number: 9090652
    Abstract: The present invention relates to compounds of formula (I): wherein R is hydrogen or alpha-hydroxy, the hydroxyl group in position 7 is in the alpha or beta position; and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: July 28, 2015
    Assignee: INTERCEPT PHARMACEUTICALS, INC.
    Inventors: Roberto Pellicciari, Stefano Fiorucci, Mark Pruzanski
  • Thienyl- and furanyl-isoquinolinones and methods for using them
    Patent number: 9079915
    Abstract: The present invention relates to substituted thienyl- and furanyl-isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thienyl and furanyl-isoquinolinones and to their use in treating various diseases and disorders.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: July 14, 2015
    Inventors: Roberto Pellicciari, Flavio Moroni, Eric Christian Hansen, Adam Matthew Gilbert, Peter John Larkin
  • Steroids as Agonists for FXR
    Publication number: 20150166598
    Abstract: The invention relates to compounds of formula (I): wherein R is ethyl, propyl or allyl, and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof. The compounds of formula (I) are useful as FXR agonists.
    Type: Application
    Filed: February 26, 2015
    Publication date: June 18, 2015
    Inventor: Roberto Pellicciari
  • Thiazolyl- And Oxazolyl-Isoquinolinones And Methods For Using Them
    Publication number: 20150133443
    Abstract: The present invention relates to substituted thiazolyl- and oxazolyl-isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thiazolyl- and oxazolyl-isoquinolinones and to their use in treating various diseases and disorders.
    Type: Application
    Filed: November 7, 2014
    Publication date: May 14, 2015
    Inventors: Roberto Pellicciari, Flavio Moroni
  • TGR5 modulators and methods of use thereof
    Patent number: 8999964
    Abstract: The invention relates to compounds of Formula (A): (A) or a salt, solvate, hydrate, or amino acid conjugate thereof. The compounds of formula A are TGR5 modulators useful for the prevention and treatment of disease.
    Type: Grant
    Filed: November 19, 2009
    Date of Patent: April 7, 2015
    Assignee: Intercept Pharmaceuticals, Inc.
    Inventor: Roberto Pellicciari
  • Steroids as agonists for FXR
    Patent number: 8969330
    Abstract: The invention relates to compounds of formula (I): wherein R is ethyl, propyl or allyl, and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof. The compounds of formula (I) are useful as FXR agonists.
    Type: Grant
    Filed: February 7, 2013
    Date of Patent: March 3, 2015
    Assignee: Intercept Pharmaceuticals, Inc.
    Inventor: Roberto Pellicciari
  • Farnesoid X receptor modulators
    Publication number: 20140371190
    Abstract: The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt, solvate, or amino acid conjugate thereof, wherein R1, R2, R3, R4, R5, and R6 are as described herein. The present invention relates generally to selective FXR agonists and to methods of making and using them.
    Type: Application
    Filed: May 14, 2014
    Publication date: December 18, 2014
    Inventor: Roberto Pellicciari
  • Thiazolyl- and oxazolyl-isoquinolinones and methods for using them
    Patent number: 8906935
    Abstract: The present invention relates to substituted thiazolyl- and oxazolyl-isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thiazolyl- and oxazolyl-isoquinolinones and to their use in treating various diseases and disorders.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: December 9, 2014
    Inventors: Roberto Pellicciari, Flavio Moroni, Adam Gilbert
  • TGR5 modulators and methods of use thereof
    Patent number: 8796249
    Abstract: The invention relates to compounds of Formula A: (A) or a salt, solvate, or hydrate thereof. The compounds of formula A are TGR5 modulators useful for the treatment of disease.
    Type: Grant
    Filed: July 30, 2009
    Date of Patent: August 5, 2014
    Assignee: Intercept Pharmaceuticals, Inc.
    Inventor: Roberto Pellicciari
  • Thienyl- and Furanyl-Isoquinolinones and Methods for Using Them
    Publication number: 20140107117
    Abstract: The present invention relates to substituted thienyl- and furanyl-isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thienyl and furanyl-isoquinolinones and to their use in treating various diseases and disorders.
    Type: Application
    Filed: December 13, 2013
    Publication date: April 17, 2014
    Inventors: Roberto Pellicciari, Flavio Moroni
  • Bile Acid Derivatives as FXR Ligands for the Prevention or Treatment of FXR-Mediated Diseases or Conditions
    Publication number: 20140057886
    Abstract: The present invention relates to compounds of formula (I): wherein R is hydrogen or alpha-hydroxy, the hydroxyl group in position 7 is in the alpha or beta position; and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof.
    Type: Application
    Filed: August 28, 2013
    Publication date: February 27, 2014
    Applicant: INTERCEPT PHARMACEUTICALS, INC.
    Inventors: Roberto Pellicciari, Stefano Fiorucci, Mark Pruzanski
  • Thienyl-and furanyl-isoquinolinones and methods for using them
    Patent number: 8633215
    Abstract: The present invention relates to substituted thienyl- and furanyl-isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thienyl and furanyl-isoquinolinones and to their use in treating various diseases and disorders.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: January 21, 2014
    Inventors: Roberto Pellicciari, Flavio Moroni, Eric Christian Hansen, Adam Matthew Gilbert, Peter John Larkin