Patents by Inventor Robertus Antonius Mijndert Van Der Hoeven
Robertus Antonius Mijndert Van Der Hoeven has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11540544Abstract: The present invention relates to a steviol glycoside having the formula of (I) wherein at least 3 sugar moieties are present at positions R1 and at least three sugar moieties are present at position R2 and wherein the steviol glycoside comprises at least seven sugar moieties all of which are linked, directly or indirectly, to the steviol aglycon by ?-linkages.Type: GrantFiled: April 22, 2022Date of Patent: January 3, 2023Assignee: DSM IP ASSETS B.V.Inventors: Robertus Antonius Mijndert Van Der Hoeven, Peter Philip Lankhorst, Silvia Gosiewska
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Publication number: 20220256903Abstract: The present invention relates to a steviol glycoside having the formula of (I) wherein at least 3 sugar moieties are present at positions R1 and at least three sugar moieties are present at position R2 and wherein the steviol glycoside comprises at least seven sugar moieties all of which are linked, directly or indirectly, to the steviol aglycon by p-linkages.Type: ApplicationFiled: April 22, 2022Publication date: August 18, 2022Inventors: Robertus Antonius Mijndert VAN DER HOEVEN, Peter Philip LANKHORST, Silvia GOSIEWSKA
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Patent number: 11344051Abstract: The present invention relates to a steviol glycoside having the formula of (I) wherein at least 3 sugar moieties are present at positions R1 and at least three sugar moieties are present at position R2 and wherein the steviol glycoside comprises at least seven sugar moieties all of which are linked, directly or indirectly, to the steviol aglycon by ?-linkages.Type: GrantFiled: April 4, 2016Date of Patent: May 31, 2022Assignee: DSM IP ASSETS B.V.Inventors: Robertus Antonius Mijndert Van Der Hoeven, Peter Philip Lankhorst, Silvia Gosiewska
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Publication number: 20180070622Abstract: The present invention relates to a steviol glycoside having the formula of (I) wherein at least 3 sugar moieties are present at positions R1 and at least three sugar moieties are present at position R2 and wherein the steviol glycoside comprises at least seven sugar moieties all of which are linked, directly or indirectly, to the steviol aglycon by ?-linkages.Type: ApplicationFiled: April 4, 2016Publication date: March 15, 2018Inventors: Robertus Antonius Mijndert VAN DER HOEVEN, Peter Philip LANKHORST, Silvia GOSIEWSKA
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Publication number: 20170191091Abstract: The present invention relates to a recombinant cell which is capable of producing one or more of itaconic acid, 4-methyl itaconate or 1-methyl itaconate, wherein the said recombinant microorganism has been modified in its genome such that it results in a deficiency in the production of a trans-aconitate methyltransferase. A recombinant yeast cell which is capable of producing itaconic acid and which overexpresses: —a nucleic acid encoding a polypeptide having cis-aconitate decarboxylase activity; and —one or more nucleic acids encoding polypeptides which separately or together catalyze a reaction towards acetyl CoA, wherein the said recombinant microorganism has been modified in its genome such that it results in a deficiency in the production of a trans-aconitate methyltransferase. These recombinant yeast cells may be used in processes for the production of itaconic acid, 4-methyl itaconate or 1-methyl itaconate.Type: ApplicationFiled: May 28, 2015Publication date: July 6, 2017Inventors: Zheng ZHAO, Bernard MEIJRINK, Robertus Antonius Mijndert VAN DER HOEVEN, Liang WU, Johannes Andries ROUBOS, Marina VAN GELDER
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Publication number: 20160153017Abstract: The present invention relates to a recombinant microorganism whereby expression of nucleotide sequence(s) confer(s) on the microorganism the ability to produce at least rebaudioside M. Such a recombinant microorganism may be used in a method of production of rebaudioside M.Type: ApplicationFiled: July 15, 2014Publication date: June 2, 2016Inventors: Robertus Antonius Mijndert VAN DER HOEVEN, Igor GALAEV, Viktor Marius BOER
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Publication number: 20150291986Abstract: The present invention relates to a recombinant yeast cell which is capable of producing one or more of 4-methyl itaconate or 1-methyl itaconate. The invention also relates to a recombinant yeast cell which is capable of producing itaconic acid and which overexpresses: a nucleic acid encoding a polypeptide having cis-aconitate decarboxylase activity; and a nucleic acid encoding a polypeptide which catalyzes a reaction towards acetyl CoA. These recombinant yeast cells may be used in processes for the production of itaconic acid, 4-methyl itaconate or 1-methyl itaconate.Type: ApplicationFiled: November 25, 2013Publication date: October 15, 2015Inventors: Zheng Zhao, Bernard Meijrink, Robertus Antonius Mijndert Van Der Hoeven, Liang Wu, Johannes Andries Roubos
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Patent number: 8945898Abstract: The present invention relates to a method for the production of a compound of interest by microbial fermentation, wherein the microbial host cell used has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The present invention further relates to a microbial host cell that has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The invention further relates to a compound of interest.Type: GrantFiled: July 1, 2011Date of Patent: February 3, 2015Assignee: DSM IP Assets B.V.Inventors: Noel Nicolaas Maria Elisabeth Van Peij, Marcus Hans, Martina Beishuizen, Dick Schipper, Robertus Antonius Mijndert Van Der Hoeven, Olaf Leonardus Schouten
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Publication number: 20140206036Abstract: The present invention relates to a process for the proteolytic hydrolysis of a peptide or a polypeptide, said peptide or polypeptide comprising 4 to 40, preferably 5 to 35, amino acid residues and said peptide or polypeptide is not hydrolysable by subtilisin whereby said peptide or polypeptide is hydrolysed by a proline specific endo protease at a pH of 6.5 or lower, preferably 5.5 or lower and more preferably 5.0 or lower to hydrolyse said peptide or polypeptide.Type: ApplicationFiled: September 9, 2013Publication date: July 24, 2014Applicant: DSM IP ASSETS B.V.Inventors: Luppo EDENS, Robertus Antonius Mijndert VAN DER HOEVEN, Andre Leonardus DE ROOS, Melissa HARVEY
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Patent number: 8524225Abstract: The present invention relates to a process for the proteolytic hydrolysis of a peptide or a polypeptide, said peptide or polypeptide comprising 4 to 40, preferably 5 to 35, amino acid residues and said peptide or polypeptide is not hydrolysable by subtilisin whereby said peptide or polypeptide is hydrolysed by a proline specific endo protease at a pH of 6.5 or lower, preferably 5.5 or lower and more preferably 5.0 or lower to hydrolyse said peptide or polypeptide.Type: GrantFiled: September 23, 2004Date of Patent: September 3, 2013Assignee: DSM IP Assets B.V.Inventors: Luppo Edens, Melissa Harvey, Robertus Antonius Mijndert Van Der Hoeven, Andre Leonardus De Roos
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Publication number: 20130144034Abstract: The present invention relates to a method for the production of a compound of interest by microbial fermentation, wherein the microbial host cell used has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The present invention further relates to a microbial host cell that has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The invention further relates to a compound of interest.Type: ApplicationFiled: July 1, 2011Publication date: June 6, 2013Applicant: DSM IP ASSETS B.V.Inventors: Noel Nicolaas Maria Elisabeth Van Peij, Marcus Hans, Martina Beishuizen, Dick Schipper, Robertus Antonius Mijndert Van Der Hoeven, Olaf Leonardus Schouten
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Publication number: 20110142987Abstract: The present invention relates to a process for the proteolytic hydrolysis of a peptide or a polypeptide, said peptide or polypeptide comprising 4 to 40, preferably 5 to 35, amino acid residues and said peptide or polypeptide is not hydrolysable by subtilisin whereby said peptide or polypeptide is hydrolysed by a proline specific endo protease at a pH of 6.5 or lower, preferably 5.5 or lower and more preferably 5.0 or lower to hydrolyse said peptide or polypeptide.Type: ApplicationFiled: October 18, 2010Publication date: June 16, 2011Applicant: DSM IP Assets B.V.Inventors: Luppo Edens, Robertus Antonius Mijndert Van Der Hoeven, Andre Leonardus De Roos, Melissa Harvey
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Patent number: 7608697Abstract: A method of enzymatically producing a protein hydrolysate from a protein substrate is described, wherein a proline-specific endoprotease or a composition containing a proline-specific endoprotease and optionally a subtilisin or a metallo endoprotease, and other enzymes such as carboxypeptidases, is used to produce a protein hydrolysate enriched in peptide fragments having a carboxy terminal proline residue. Such protein hydrolysates may be used as such or to reduce bitterness in foods nutritionally supplemented by protein hydrolysates, as well as to produce hydrolysate containing foodstuffs having low antigenicity.Type: GrantFiled: December 6, 2001Date of Patent: October 27, 2009Assignee: DSM IP Assets B.V.Inventors: Luppo Edens, Robertus Antonius Mijndert Van Der Hoeven, Veronique Delest
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Patent number: 7309595Abstract: The present invention provides An isolated polypeptide which has proline specific endoprotease activity, selected from the group consisting of:(a) a polypeptide which has an amino acid sequence which has at least 40% amino acid sequence identity with amino acids 1 to 526 of SEQ ID NO:2 or a fragment thereof;(b) a polypeptide which is encoded by a polynucleotide which hybridizes under low stringency conditions with (i) the nucleic acid sequence of SEQ ID NO:1 or a fragment thereof which is at least 80% or 90% identical over 60, preferably over 100 nucleotides, more preferably at least 90% identical over 200 nucleotides, or (ii) a nucleic acid sequence complementary to the nucleic acid sequence of SEQ ID NO:1.Type: GrantFiled: December 6, 2001Date of Patent: December 18, 2007Assignee: DSM IP Assets B.V.Inventors: Petrus Jacobus Theodorus Dekker, Luppo Edens, Robertus Antonius Mijndert Van Der Hoeven, Linda De Lange
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Publication number: 20070207944Abstract: The present invention describes a process to produce IPP from a protein source whereby the ratio of IPP and VPP produced from the protein is at least 5, preferably at least 10 and more preferably at least 20, which comprises the use of a proline specific endoprotease.Type: ApplicationFiled: July 12, 2005Publication date: September 6, 2007Inventors: Luppo Edens, Andre Leonardus De Roos, Robertus Antonius Mijndert Van Der Hoeven, Philippus Antonius Deen
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Publication number: 20040241664Abstract: The present invention provides An isolated polypeptide which has proline specific endoprotease activity, selected from the group consisting of:(a) a polypeptide which has an amino acid sequence which has at least 40% amino acid sequence identity with amino acids 1 to 526 of SEQ ID NO:2 or a fragment thereof;(b) a polypeptide which is encoded by a polynucleotide which hybridizes under low stringency conditions with (i) the nucleic acid sequence of SEQ ID NO:1 or a fragment thereof which is at least 80% or 90% identical over 60, preferably over 100 nucleotides, more preferably at least 90% identical over 200 nucleotides, or (ii) a nucleic acid sequence complementary to the nucleic acid sequence of SEQ ID NO:1.Type: ApplicationFiled: November 10, 2003Publication date: December 2, 2004Inventors: Petrus Jacobus Theodorus Dekker, Luppo Edens, Robertus Antonius Mijndert Van Der Hoeven, Linda De Lange