Abstract: Provided herein modified dehalogenases have extended surface loop regions that provide a location for internal fusion insertions and modulate binding interaction and activation of environmentally-sensitive chemistries.

Abstract: A method for configuring a system having a wearable optical unit is disclosed. The method includes powering on the system, and in response to the system being powered on, using one or more processors to control the system to: determine whether to cause the system to run a configuration workflow, and in response to determining to cause the system to run the configuration workflow, (a) control the system in connection with configuring an interpupillary distance (IPD) for a user of the system, (b) determine whether the IPD is configured for the user, and (c) in response to determining that the IPD is configured for the user, control the system in connection with configuring a focus of the optical unit.

Abstract: A trepanning apparatus, including a shaft portion extending along a longitudinal axis; an annular cutter portion; and a connecting portion extending axially between the shaft portion and the cutter portion, the connecting portion including a pair of arms each having a front end connected to the cutter portion and a rear end connected to the shaft portion, the arms circumferentially spaced from one another about the longitudinal axis to provide diametrically opposed first and second openings, a first plug retaining surface defined by a first portion of the rearward end of the cutter portion having a first circumferential extent bounded by the front ends of the arms, and a second plug retaining surface defined by a second portion of the rearward end of the cutter portion having a second circumferential extent bounded by the front ends of the arms, the first circumferential extent greater than the second circumferential extent.

Abstract: A trepanning apparatus, including a shaft portion extending along a longitudinal axis; an annular cutter portion; and a connecting portion extending axially between the shaft portion and the cutter portion, the connecting portion including a pair of arms each having a front end connected to the cutter portion and a rear end connected to the shaft portion, the arms circumferentially spaced from one another about the longitudinal axis to provide diametrically opposed first and second openings, a first plug retaining surface defined by a first portion of the rearward end of the cutter portion having a first circumferential extent bounded by the front ends of the arms, and a second plug retaining surface defined by a second portion of the rearward end of the cutter portion having a second circumferential extent bounded by the front ends of the arms, the first circumferential extent greater than the second circumferential extent.

Abstract: A downhole cutting tool is operable, when deployed, to create a cut through a wall of a tubular member, for example a downhole casing, tubing or drill pipe. The downhole cutting tool comprises a tool head assembly, comprising a tubular body, which provides a housing, which houses a cutting member, a first anchor located downstream of the cutting member and a second anchor member located upstream of the cutting member.

Abstract: A downhole cutting tool is operable, when deployed, to create a cut through a wall of a tubular member, for example a downhole casing, tubing or drill pipe. The downhole cutting tool comprises a tool head assembly, comprising a tubular body, which provides a housing, which houses a cutting member, a first anchor located downstream of the cutting member and a second anchor member located upstream of the cutting member.