Patents by Inventor Roderick O'Connor

Roderick O'Connor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Activation and Expansion of T Cell Subsets Using Biocompatible Solid Substrates with Tunable Rigidity
    Publication number: 20230137331
    Abstract: The present invention provides compositions and methods for activation and expansion of T cells using a biocompatible solid substrate with tunable rigidity. Rigidity of a substrate is an important parameter that can be used to control the overall expansion and differentiation of T cells.
    Type: Application
    Filed: June 13, 2022
    Publication date: May 4, 2023
    Inventors: Michael C. Milone, Lance C. Kam, Keyue Shen, Xueli Hao, Roderick O'Connor, Geraldine Goebrecht
  • METHODS OF MAKING CHIMERIC ANTIGEN RECEPTOR-EXPRESSING CELLS
    Publication number: 20220168389
    Abstract: The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), and compositions and reaction mixtures comprising the same.
    Type: Application
    Filed: April 10, 2020
    Publication date: June 2, 2022
    Applicants: Novartis AG, The Trustees of the University of Pennsylvania
    Inventors: Saba Ghassemi, Michael C. Milone, Roderick O'Connor
  • IMMUNOTHERAPY WITH METABOLIC ENZYME EXPRESSION
    Publication number: 20210379109
    Abstract: The present invention provides, in some embodiments, methods of promoting an immune response in a subject in need thereof, comprising administering to the subject a population of immune cells that express an enzyme that facilitates immune cell function in a nutrient-poor environment. The invention also provides, in other embodiments, compositions comprising an ex vivo population of immune cells expressing an enzyme that enhances immune cell function in a nutrient-poor environment.
    Type: Application
    Filed: August 23, 2019
    Publication date: December 9, 2021
    Inventors: Joshua D. Rabinowitz, Roderick O'Connor
  • METHODS OF MAKING CHIMERIC ANTIGEN RECEPTOR-EXPRESSING CELLS
    Publication number: 20200370012
    Abstract: The disclosure provides methods of making CAR-expressing immune effector cells (e.g., T cells, or NK cells), and compositions and reaction mixtures comprising the same. The disclosure further provides methods of using said CAR-expressing immune effector cells.
    Type: Application
    Filed: October 25, 2018
    Publication date: November 26, 2020
    Inventors: Joseph A. Fraietta, Jan J. Melenhorst, Elena Orlando, Roderick O'Connor, Carl H. June
  • Activation and Expansion of T Cell Subsets Using Biocompatible Solid Substrates with Tunable Rigidity
    Publication number: 20150030619
    Abstract: The present invention provides compositions and methods for activation and expansion of T cells using a biocompatible solid substrate with tunable rigidity. Rigidity of a substrate is an important parameter that can be used to control the overall expansion and differentiation of T cells.
    Type: Application
    Filed: September 6, 2012
    Publication date: January 29, 2015
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Michael C. Milone, Lance C. Kam, Keyue Shen, Hueli Hao, Roderick O'Connor, Geraldine Goebrecht