Abstract: A method for manufacturing an implant can include receiving at a computing device, patient specific data related to a bone of a patient and implant data related to an implant for the patient, and determining, by the computing device, optimal design parameters for the implant for the patient using the patient specific data and a machine learning model. The method can also include exporting, by the computing device, the optimal design parameters to a manufacturing device of systems for manufacturing the implant. The optimal design parameters can provide for a non-solid implant construction in regions of lower stress within the bone of the patient and a solid implant construction in regions for higher stress within the bone of the patient to bring stress distributions closer to those experienced in a non-implanted bone to, in turn, reduce the likelihood of bone resorption and peri-prosthetic fractures after implantation of the implant.

Abstract: One embodiment provides a shoulder strap system comprising one or more self-adjusting shoulder straps and one or more connectors for interconnecting the shoulder straps to a body garment intended to be worn by a wearer. Each shoulder strap comprises a casing including one or more fabric layers forming an exterior of the casing and an elastic segment interconnected to a webbing segment, where the elastic segment and the webbing segment are disposed inside the casing and concealed by the fabric layers. Each elastic segment inside each casing of each shoulder strap is stretchable to dynamically adjust to a physical build or a movement of the wearer, such that each shoulder strap operates independently to increase mobility and range of motion of the wearer.

Abstract: Multiple sclerosis (MS) is an autoimmune, neurodegenerative disease affecting at least 400,000 individuals in the United States and 2.3 million persons worldwide. Its counterpart in the peripheral nervous system, chronic Inflammatory demyelinating polyradiculoneuropathy (CIPD), affects approximately 40,000 patients In the United States. Both diseases have a relatively young age at diagnosis and require lifelong therapy to slow progression. These two diseases both result from the immune system attacking the integrity of the myelin sheath, the protective coating of neurons. The therapies common to these two diseases are corticosteroids, and plasma exchange/IVIG therapy for the treatment of symptoms, and they are generally immunosuppressive. Hence, there is a need to develop a therapy that would selectively inhibit the specific pathological entities like autoantibodies that bind to the myelin sheath.

Abstract: A user equipment (UE) is connected to a wireless network and operates in a carrier aggregation (CA) state that includes a first connection to a primary cell and a second connection to a secondary cell. The UE determines a beam failure has occurred for one of the first connection or the second connection and initiates a beam failure recovery (BFR) operation. The BFR operation includes transmitting, to the primary cell, a BFR Medium Access Control (MAC) Control Element (CE).

Abstract: The disclosure is of and includes at least an apparatus, system and method for a print head for additive manufacturing. The apparatus, system and method may include at least two proximate hobs suitable to receive and extrude therebetween a print material filament for the additive manufacturing; a motor capable of imparting a rotation to at least one of the two hobs, wherein the extrusion results from the rotation; a dynamic force adjustment capable of exerting force on one of the two hobs to urge the force-receiving hob toward the other of the two hobs; and a controller communicatively connected with the dynamic force adjustment and capable of controlling the force exertion thereof.

Abstract: A method for securing data access by containerized applications includes intercepting, by a first container executing on a first computing device and associated with a containerized application in a second container executing on the first computing device, a first Internet Protocol (IP) request from the containerized application. The first container determines that the IP request is addressed to a second computing device executing a resource that the containerized application is authorized to access. The first container encrypts a payload portion of the IP request and transmits, to the resource, a second IP request with the encrypted payload portion. The first container receives, from the resource, a response. The first container requests, from a third computing device, a cryptographic key for decrypting the response. The first container decrypts, with the cryptographic key, a payload portion of the response and transmits, to the containerized application, the decrypted payload portion of the response.

Abstract: A medical device comprising an implantable subcutaneous access port having a septum penetrable by a needle; the septum having a cavity located between an outer wall and an inner wall, the cavity containing a flowable media comprising a plurality of displaceable particles arranged to move in response to the needle being inserted through the outer wall and into the cavity and reposition around the needle.

Abstract: The disclosure relates to methods of using selective inhibitors of VEGFR2 and FGFR1 to promote lipid storage and fat increase, and for treatment of a wasting syndrome.

Abstract: The present invention includes one or more nanopores in a SixNy membrane comprising a monoprotic surface termination, methods of making, and methods of using the one or more nanopores, where the one or more nanopores are a chemically-tuned controlled dielectric breakdown (CT-CDB) nanopore membrane, wherein the CT-CDB allows for long-term stability of measurements in the presence of only electrolyte (open pore current stability) and ability to support many molecular detection events. In addition, the CT-CBD has pore that unclog spontaneously, in response to voltage cessation or application, or both.

Abstract: Apparatus, system, and method for separating gas from a composite fluid. The apparatus includes a main body defining a flow path formed from a separations chamber at an upstream end of the flow path and a head space chamber at the downstream end of the flow path. The main body includes a first set of apertures disposed about the separations chamber and a second set of apertures disposed about the head space chamber. An agitator is housed within the main body at an upstream end of the separations chamber and is configured to generate a vortex that conveys the composite fluid through the flow path. The vortex expels a liquid fraction and a solids fraction of the composite fluid from the first set of apertures, and the vortex conveys a gaseous fraction of the composite fluid into the head space chamber for extraction from the second set of apertures.

Abstract: Gaming systems, gaming devices and methods that provide games that control volatility. In one embodiment, the gaming system disclosed herein enables a player to select values, or cells associated with values, that are displayed in a particular arrangement. The player selected values are distributed to other values or cells according to one or more predefined rules. In one embodiment, one or more of the player selectable values are progressive award values. At some point during the game, the gaming system randomly picks one of the remaining values that have not been selected and provides an award to the player based at least in part on the selected value.

Abstract: The disclosure is of and includes at least an apparatus, system and method for a print head for additive manufacturing. The apparatus, system and method may include at least two proximate hobs suitable to receive and extrude therebetween a print material filament for the additive manufacturing; a motor capable of imparting a rotation to at least one of the two hobs, wherein the extrusion results from the rotation; a dynamic force adjustment capable of exerting force on one of the two hobs to urge the force-receiving hob toward the other of the two hobs; and a controller communicatively connected with the dynamic force adjustment and capable of controlling the force exertion thereof.

Abstract: The present disclosure, in some aspects, is directed to nucleic acid purification methods using a water-immiscible solvent wash. In other aspects, the present disclosure is directed to kits, components, and compositions (such as consumables) useful for the nucleic acid purification methods described herein.

Abstract: The system can include: a vehicle 100 and a stabilizer 200. However, the system can additionally or alternatively include any other suitable set of components. The system functions to facilitate vehicular transport (e.g., via a cabin). Additionally, the system can provide impact attenuation and/or mitigate rebound of the vehicle during a water landing. Additionally or alternatively, the system can function to provide aquatic stabilization of the vehicle and/or cabin thereof. However, the system 100 can provide any other suitable functionalities.

Abstract: A downhole tool includes a housing; a first piston arranged within the housing such that it can move axially under the action of fluid flowing through the tool; and an indexer configured to control axial movement of the first piston between a first, second and third axial position. The indexer is configured such that the first piston can be selectively moved into the third position in accordance with a variation of a flow of fluid through the tool. A second piston is movable between a closed position in which fluid flowing through the tool is restricted from communicating with an activation chamber and an open position in which fluid flowing through the tool is permitted to communicate with the activation chamber; wherein the second piston is configured to move between the closed position and the open position in response to the first piston moving to the third axial position.

Abstract: A method of manufacturing a hydrogen fuel cell hose and component parts is disclosed herein, including blending a formaldehyde-based, semi-crystalline engineering thermoplastic with graphene, wherein the graphene has a thickness of less than about 3.2 nm, a particle size of between about 50 nm and about 10 ?m, and contains greater than about 95% carbon, exfoliating the graphene into plates, wherein the graphene plates having substantially no carboxylic acid, alcohols, ketones, aldehydes, or hydroxyl groups on the graphene plate surface or graphene plate edges, and aligning the graphene plates into perpendicular alignment, such that the graphene plates provide a barrier to migration of oxygen, nitrogen, moisture, or water vapor molecules.

Abstract: An electronic motor drive for powering permanent magnet air core synchronous motors having sinusoidal back emf includes a switchmode power converter coupled to a connection of an input power supply. The power converter converts power from the input power supply with a current-mode control output and regulates current to a variable voltage link that supplies the regulated current to a non-modulating commutation inverter that energizes multi-phase air core armature windings of the air core motor. The motor drive employs 6-step position sensorless commutation exciting only two phase legs at a time controlled through measurement of the back emf. The switchmode power converter includes a low pass inductance and capacitance filter ahead of a power supply of the commutation inverter. The regulated current is switched at a regulation frequency high enough to preclude significant switching-induced harmonic ripple currents to the air core armature windings.

Abstract: An interactive object control system includes one or more processors and memory storing instructions, that when executed by the one or more processors cause the one or more processors to determine a respective signal strength of respective signals received at communication circuitry from respective interactive objects of multiple of interactive objects in an interactive environment. The instructions, when executed by the one or more processors, cause the one or more processors to select a best candidate interactive object from the multiple of interactive objects based on the respective signal strength of the respective signals and send instructions to the best candidate interactive object to activate one or more object emitters of the best candidate interactive object.

Abstract: An attraction system for entertaining guests includes a millimeter wave (mmWave) sensor configured to transmit a signal within the attraction system and to receive a reflection of the signal and a control system communicatively coupled to the mmWave sensor. The mmWave sensor is configured to transmit data to the control system based on the reflection of the signal, and the control system is configured to perform operations that include determining a target operation of the attraction system based on the data received from the mmWave sensor and operating the attraction system based on the target operation.

Abstract: Baseball caps to be worn on a person's head are provided. According to one embodiment, a baseball cap includes a dome configured to be placed on the wearer's head, wherein the dome includes one or more panels and one or more cooling channels. The baseball cap also includes a hub positioned at a top of the dome. The hub comprises a central cavity and one or more conduits in gaseous communication with the one or more cooling channels of the dome. A coolant output port is provided in gaseous communication with the central cavity of the hub. The coolant output port is configured to supply a coolant gas to the one or more cooling channels of the dome via the central cavity of the hub.