Patents by Inventor Rodolfo Pescador

Rodolfo Pescador has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA-based aptamers for human cathepsin G
    Patent number: 7838506
    Abstract: The present research is directed to the identification of non-peptidic inhibitors of cathepsin G characterised by high levels of selectivity and which can be efficaciously used in the treatment and prophylaxis of inflammatory occurrences and procoagulant conditions. The cathepsin G-inhibiting aptamers according to the invention consist of linear DNA or polynucleotide sequences having a chain length of at least 60 nucleotides and being substantially not subjected to undergo efficient base pairing.
    Type: Grant
    Filed: January 17, 2008
    Date of Patent: November 23, 2010
    Assignee: Gentium SpA
    Inventors: Manlio Palumbo, Barbara Gatto, Rodolfo Pescador, Roberto Porta, Laura Iris Ferro
  • DNA-BASED APTAMERS FOR HUMAN CATHEPSIN G
    Publication number: 20080176814
    Abstract: The present research is directed to the identification of non-peptidic inhibitors of cathepsin G characterised by high levels of selectivity and which can be efficaciously used in the treatment and prophylaxis of inflammatory occurrences and procoagulant conditions. The cathepsin G-inhibiting aptamers according to the invention consist of linear DNA or polynucleotide sequences having a chain length of at least 60 nucleotides and being substantially not subjected to undergo efficient base pairing.
    Type: Application
    Filed: January 17, 2008
    Publication date: July 24, 2008
    Applicant: GENTIUM SPA
    Inventors: Manlio PALUMBO, Barbara GATTO, Rodolfo PESCADOR, Roberto PORTA, Laura Iris FERRO
  • DNA-based aptamers for human cathepsin G
    Publication number: 20060148745
    Abstract: The present research is directed to the identification of non-peptidic inhibitors of cathepsin G characterised by high levels of selectivity and which can be efficaciously used in the treatment and prophylaxis of inflammatory occurrences and procoagulant conditions. The cathepsin G-inhibiting aptamers according to the invention consist of linear DNA or polynucleotide sequences having a chain length of at least 60 nucleotides and being substantially not subjected to undergo efficient base pairing.
    Type: Application
    Filed: September 27, 2005
    Publication date: July 6, 2006
    Inventors: Manlio Palumbo, Barbara Gatto, Rodolfo Pescador, Roberto Porta, Laura Ferro
  • Sulfoamino derivatives of chondroitin sulfates of dermatan sulfate and of hyaluronic acid and their pharmacological properties
    Patent number: 5008253
    Abstract: Novel derivatives are disclosed as obtained from chondroitin sulfate, dermatan sulfate and hyaluronic acid, having a molar ratio between sulfate groups and carboxylic groups like that of heparin and furthermore characterized by possessing, as the heparin, the sulfoamino group at the carbon atom at the 6 position of hexosamine.The novel compounds show a very remarkable clearing activity in comparison with the starting mucopolysaccharides, this activity being similar and for some derivatives comparable with that of heparin.Moreover, differently from what normally happens upon sulfating the sulfomucopolysaccharides, the anticoagulating activity of the novel compounds is negligible or anyhow very reduced.The compounds of the present invention find use in the therapy of arteriosclerosis.
    Type: Grant
    Filed: May 2, 1989
    Date of Patent: April 16, 1991
    Assignee: Crinos Industria Farmacobiologica S.p.A.
    Inventors: Benito Casu, Giangiacomo Torri, Annamaria Naggi, Marisa Mantovani, Rodolfo Pescador, Roberto Porta, Giuseppe Prino