Patents by Inventor RODOLPHE HAJJ

RODOLPHE HAJJ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EARLY TREATMENT OF CMT DISEASE
    Publication number: 20210260053
    Abstract: The present invention provides methods for treating, preventing, or delaying the onset of Charcot-Marie-Tooth Disease type 1A (CMT1A), by administering to a subject in need thereof a combination comprising baclofen, sorbitol and naltrexone, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: March 8, 2021
    Publication date: August 26, 2021
    Inventors: Daniel Cohen, Ilya Chumakov, Rodolphe Hajj, Aude Milet, Serguei Nabirochkin, Klaus-Armin Nave, Thomas Prukop, Michael Sereda
  • BACLOFEN AND ACAMPROSATE BASED THERAPY OF ALZHEIMER'S DISEASE IN PATIENTS HAVING LOST RESPONSIVENESS TO ACETYLCHOLINESTERASE INHIBITOR THERAPY
    Publication number: 20210236445
    Abstract: The present invention relates to combinations and methods based on Baclofen and Acamprosate for the treatment of Alzheimer's disease or Alzheimer's related disorders in patients who do not respond to an inhibitor of acetylcholinesterase, typically in patients treated with an inhibitor of acetylcholinesterase and who have lost responsiveness to said inhibitor of acetylcholinesterase.
    Type: Application
    Filed: January 28, 2019
    Publication date: August 5, 2021
    Inventors: ANTHONY BRUREAU, NATHALIE CHOLET, DANIEL COHEN, RODOLPHE HAJJ, SERGUEI NABIROCHKIN
  • Early treatment of CMT disease
    Patent number: 10940147
    Abstract: The present invention provides methods for treating, preventing, or delaying the onset of Charcot-Marie-Tooth Disease type 1A (CMT1A), by administering to a subject in need thereof a combination comprising baclofen, sorbitol and naltrexone, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: July 8, 2019
    Date of Patent: March 9, 2021
    Assignee: Pharnext
    Inventors: Daniel Cohen, Ilya Chumakov, Rodolphe Hajj, Aude Milet, Serguei Nabirochkin, Klaus-Armin Nave, Thomas Prukop, Michael Sereda
  • Combination of baclofen, acamprosate and medium chain triglycerides for the treatment of neurological disorders
    Patent number: 10905672
    Abstract: The present invention relates to combinations and methods for the treatment of neurological disorders related to amyloid beta toxicity and/or neuronal death and/or glucose-impaired neuronal metabolism. More specifically, the present invention relates to novel combinatorial therapies of Alzheimer's disease, Alzheimer's disease-related disorders, frontotemporal dementia, Parkinson's disease, Lewy body dementia, Huntington's disease, peripheral neuropathies, alcoholism or alcohol withdrawal, neurological manifestations of drug abuse or drug abuse withdrawal, amyotrophic lateral sclerosis, multiple sclerosis, spinal cord injury, epilepsy, traumatic brain injury or brain ischemic events based on baclofen, acamprosate and at least one medium chain triglyceride.
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: February 2, 2021
    Assignee: PHARNEXT
    Inventors: Daniel Cohen, Ilya Chumakov, Serguei Nabirochkin, Rodolphe Hajj
  • Combinatorial therapies of neurological disorders
    Patent number: 10799499
    Abstract: The present invention relates to combinations and methods for the treatment of neurological disorders related Amyloid beta toxicity and/or neuronal death. More specifically, the present invention relates to novel combinatorial therapies of Alzheimer's disease, Alzheimer's disease related disorders, Parkinson's disease, Lewy body dementia, multiple system atrophy and other related synucleinopathies, Huntington's disease, peripheral neuropathies, alcoholism or alcohol withdrawal, neurological manifestations of drug abuse or drug abuse withdrawal, amyotrophic lateral sclerosis, multiple sclerosis, spinal cord injury, epilepsy, traumatic brain injury or brain ischemic events based on 3-phenylsulfonyl-8-(piperazin-1-yl) quinoline and baclofen and/or acamprosate.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: October 13, 2020
    Assignee: PHARNEXT
    Inventors: Daniel Cohen, Serguei Nabirotchkin, Rodolphe Hajj
  • METHOD FOR ADAPTING DOSES OF COMBINATION THERAPIES
    Publication number: 20200306211
    Abstract: The present invention relates to methods for improving dose finding process for combinations of several drugs and/or adapting the dosage of combinatorial treatment. More particularly the invention relates to methods for identifying more efficient dose of active pharmaceutical ingredients (APIs) within combination therapies. This invention also relates to methods for optimizing a therapeutic efficiency of combined therapies.
    Type: Application
    Filed: November 30, 2015
    Publication date: October 1, 2020
    Inventors: Daniel Cohen, Ilya Chumakov, Mickael Guedj, Rodolphe Hajj
  • Idalopirdine-based combinatorial therapies of Alzheimer's disease
    Patent number: 10736876
    Abstract: The present invention relates to combinatorial therapies and methods for the treatment of Alzheimer's disease or an Alzheimer's disease related disorder based on idalopirdine, baclofen and acamprosate, wherein idalopirdine is provided as suboptimal doses.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: August 11, 2020
    Assignee: PHARNEXT
    Inventors: Daniel Cohen, Serguei Nabirochkin, Rodolphe Hajj, Anthony Brureau
  • COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL
    Publication number: 20200222409
    Abstract: The present invention relates to compositions and methods for controlling glycaemia in a mammalian in need thereof. The present invention relates to compositions and methods for the treatment of diabetes disease and related disorders. More specifically, the present invention relates to novel therapies or combinatorial therapies of diabetes and related disorders, based on compositions controlling the blood glucose level.
    Type: Application
    Filed: March 26, 2020
    Publication date: July 16, 2020
    Inventors: DANIEL COHEN, ILYA CHUMAKOV, SERGUEI NABIROCHKIN, RODOLPHE HAJJ
  • Compositions for treating amyotrophic lateral sclerosis
    Patent number: 10682342
    Abstract: The present invention relates to compositions and methods for the treatment of amyotrophic lateral sclerosis. More specifically, the present invention relates to novel combinatorial therapies for treating amyotrophic lateral sclerosis or a related disorder.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: June 16, 2020
    Assignee: PHARNEXT
    Inventors: Daniel Cohen, Serguei Nabirochkin, Ilya Chumakov, Rodolphe Hajj
  • IDALOPIRDINE-BASED COMBINATORIAL THERAPIES OF ALZHEIMER'S DISEASE
    Publication number: 20200129479
    Abstract: The present invention relates to combinatorial therapies and methods for the treatment of Alzheimer's disease or an Alzheimer's disease related disorder based on idalopirdine, baclofen and acamprosate, wherein idalopirdine is provided as suboptimal doses.
    Type: Application
    Filed: April 23, 2018
    Publication date: April 30, 2020
    Inventors: DANIEL COHEN, SERGUEI NABIROCHKIN, RODOLPHE HAJJ, ANTHONY BRUREAU
  • Compositions, methods and uses for the treatment of diabetes and related conditions by controlling blood glucose level
    Patent number: 10617689
    Abstract: The present invention relates to compositions and methods for controlling glycaemia in a mammalian in need thereof. The present invention relates to compositions and methods for the treatment of diabetes disease and related disorders. More specifically, the present invention relates to novel therapies or combinatorial therapies of diabetes and related disorders, based on compositions controlling the blood glucose level.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: April 14, 2020
    Assignee: PHARNEXT
    Inventors: Daniel Cohen, Ilya Chumakov, Serguei Nabirochkin, Rodolphe Hajj
  • Compositions, methods and uses for the treatment of diabetes and related conditions by controlling blood glucose level
    Patent number: 10596160
    Abstract: The present invention relates to compositions and methods for controlling glycemia in a mammalian in need thereof. The present invention relates to compositions and methods for the treatment of diabetes and related disorders. More specifically, the present invention relates to novel therapies or combinatorial therapies for diabetes and related disorders, based on compositions controlling the blood glucose level.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: March 24, 2020
    Assignee: PHARNEXT
    Inventors: Daniel Cohen, Ilya Chumakov, Serguei Nabirochkin, Rodolphe Hajj
  • EARLY TREATMENT OF CMT DISEASE
    Publication number: 20200030314
    Abstract: The present invention provides methods for treating, preventing, or delaying the onset of Charcot-Marie-Tooth Disease type 1A (CMT1A), by administering to a subject in need thereof a combination comprising baclofen, sorbitol and naltrexone, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: July 8, 2019
    Publication date: January 30, 2020
    Inventors: Daniel Cohen, Ilya Chumakov, Rodolphe Hajj, Aude Milet, Serguei Nabirochkin, Klaus-Armin Nave, Thomas Prukop, Michael Sereda
  • Early treatment of CMT disease
    Patent number: 10383870
    Abstract: The present invention provides methods for treating, preventing, or delaying the onset of Charcot-Marie-Tooth Disease type 1A (CMT1A), by administering to a subject in need thereof a combination comprising baclofen, sorbitol and naltrexone, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: August 20, 2019
    Assignee: PHARNEXT
    Inventors: Daniel Cohen, Ilya Chumakov, Rodolphe Hajj, Aude Milet, Serguei Nabirochkin, Klaus-Armin Nave, Thomas Prukop, Michael Sereda
  • Therapeutic approaches for treating Parkinson's disease
    Patent number: 10342768
    Abstract: The present invention relates to compositions and methods for the treatment of Parkinson's disease and related disorders. More specifically, the present invention relates to novel combinatorial therapies of Parkinson's disease and related disorders targeting the alpha-synuclein aggregation network. In particular, the invention relates to compounds which, alone or in combination(s), can effectively protect neuronal cells from alpha-synuclein aggregates. The invention also relates to methods of producing a drug or a drug combination for treating Parkinson's disease and to methods of treating Parkinson's disease or a related disorder.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: July 9, 2019
    Assignee: PHARNEXT
    Inventors: Daniel Cohen, Serguei Nabirochkin, Ilya Chumakov, Rodolphe Hajj
  • Compositions for treating amyotrophic lateral sclerosis
    Patent number: 10342784
    Abstract: The present invention relates to compositions and methods for the treatment of amyotrophic lateral sclerosis. More specifically, the present invention relates to novel combinatorial therapies for treating amyotrophic lateral sclerosis or a related disorder.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: July 9, 2019
    Assignee: PHARNEXT
    Inventors: Daniel Cohen, Serguei Nabirochkin, Ilya Chumakov, Rodolphe Hajj
  • COMPOSITIONS FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS
    Publication number: 20190175568
    Abstract: The present invention relates to compositions and methods for the treatment of amyotrophic lateral sclerosis. More specifically, the present invention relates to novel combinatorial therapies for treating amyotrophic lateral sclerosis or a related disorder.
    Type: Application
    Filed: February 15, 2019
    Publication date: June 13, 2019
    Inventors: DANIEL COHEN, SERGUEI NABIROCHKIN, ILYA CHUMAKOV, RODOLPHE HAJJ
  • NOVEL COMBINATORIAL THERAPIES OF NEUROLOGICAL DISORDERS
    Publication number: 20190111054
    Abstract: The present invention relates to combinations and methods for the treatment of neurological disorders related Amyloid beta toxicity and/or neuronal death. More specifically, the present invention relates to novel combinatorial therapies of Alzheimer's disease, Alzheimer's disease related disorders, Parkinson's disease, Lewy body dementia, multiple system atrophy and other related synucleinopathies, Huntington's disease, peripheral neuropathies, alcoholism or alcohol withdrawal, neurological manifestations of drug abuse or drug abuse withdrawal, amyotrophic lateral sclerosis, multiple sclerosis, spinal cord injury, epilepsy, traumatic brain injury or brain ischemic events based on 3-phenylsulfonyl-8-(piperazin-1-yl) quinolone and baclofen and/or acamprosate.
    Type: Application
    Filed: February 3, 2017
    Publication date: April 18, 2019
    Inventors: DANIEL COHEN, SERGUEI NABIROTCHKIN, RODOLPHE HAJJ
  • COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL
    Publication number: 20190008841
    Abstract: The present invention relates to compositions and methods for controlling glycemia in a mammalian in need thereof. The present invention relates to compositions and methods for the treatment of diabetes and related disorders. More specifically, the present invention relates to novel therapies or combinatorial therapies for diabetes and related disorders, based on compositions controlling the blood glucose level.
    Type: Application
    Filed: September 12, 2018
    Publication date: January 10, 2019
    Inventors: Daniel COHEN, Ilya CHUMAKOV, Serguei NABIROCHKIN, Rodolphe HAJJ
  • COMPOSITIONS FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS
    Publication number: 20180344711
    Abstract: The present invention relates to compositions and methods for the treatment of amyotrophic lateral sclerosis. More specifically, the present invention relates to novel combinatorial therapies for treating amyotrophic lateral sclerosis or a related disorder.
    Type: Application
    Filed: August 10, 2018
    Publication date: December 6, 2018
    Inventors: DANIEL COHEN, SERGUEI NABIROCHKIN, ILYA CHUMAKOV, RODOLPHE HAJJ