Abstract: This invention relates to the use of NKG2A-targeting agents for the treatment of cancers, notably head and neck cancers, in a patient having received prior treatment with cetuximab. This invention also provides advantageous combination regimens for use with NKG2A-targeting agents for the treatment of cancers.

Abstract: A cell balancing circuit monitors the voltage between serially connected cells and compares it to a reference voltage. From that comparison, the cell balancing circuit sources or sinks current into a midpoint node between rechargeable cells to keep the cells balanced during the charging process. In one preferred embodiment, the cell balancing circuit includes an op-amp, connected in a unity gain configuration. A voltage divider establishes a reference voltage equal to the average of the two cell voltages. The op-amp compares this average to the measured voltage at the midpoint node. When the average voltage exceeds the voltage at the midpoint node, the op-amp sources current into the midpoint node. When the average voltage falls below the voltage at the midpoint node, the op-amp sinks current from the midpoint node. By sourcing or sinking current, the cell balancing circuit allows the lesser charged cell to catch up with the more fully charged cell.

Abstract: A battery protection circuit is provided that includes a safety circuit and an overpower circuit. The safety circuit monitors the voltage and current of at least one rechargeable cell within the battery pack, and disconnects the cell(s) from the external terminals of the battery pack when either the voltage becomes too high or low, or when excessive current is being drawn from the battery pack. The overpower circuit monitors the power being delivered to or sourced from the battery pack to the load. The overpower circuit actuates when the power exceeds a predetermined threshold, thereby simulating an overcurrent condition in the safety circuit. The overcurrent condition causes a disconnect means, like a transistor, to open, thereby disconnecting the cell(s) from the external terminals. The battery protection circuit then latches in this disconnected state until a load is removed from the terminals of the battery pack.