Patents by Inventor Roger M. Freidinger

Roger M. Freidinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cholecystokinin antagonists
    Patent number: 5220017
    Abstract: Benzodiazepine analogs of the formula: ##STR1## are disclosed which are antagonists of gastrin and cholecystokinin (CCK).
    Type: Grant
    Filed: March 10, 1992
    Date of Patent: June 15, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Mark G. Bock, Roger M. Freidinger
  • Cholecystokinin antagonists
    Patent number: 5218114
    Abstract: Benzodiazepine analogs of the formula: ##STR1## are disclosed which are antagonists of gastrin and cholecystokinin (CCK).
    Type: Grant
    Filed: March 10, 1992
    Date of Patent: June 8, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Mark G. Bock, Roger M. Freidinger, Robert M. DiPardo
  • Cholecystokinin antagonists
    Patent number: 5218115
    Abstract: Benzodiazepine analogs of the formula: ##STR1## are disclosed which are antagonists of gastrin and cholecystokinin (CCK).
    Type: Grant
    Filed: March 10, 1992
    Date of Patent: June 8, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Mark Bock, Roger M. Freidinger
  • 2-benzazepines with 5- and 6-membered heterocyclic rings to treat pain and anxiety disorders
    Patent number: 5210082
    Abstract: Pharmaceutical compositions containing aromatic 2-benzazepines with fused 5- or 6-membered heterocyclic rings are disclosed which are useful in the treatment of panic disorder or anxiety disorder.
    Type: Grant
    Filed: May 16, 1991
    Date of Patent: May 11, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Mark G. Bock, Ben E. Evans, Roger M. Freidinger
  • Benzolactam analogs as antagonists of CCK
    Patent number: 5206234
    Abstract: Benzolactam analogs of the formula: ##STR1## are disclosed which are antagonists of gastrin and cholecystokinin (CCK).
    Type: Grant
    Filed: June 20, 1991
    Date of Patent: April 27, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Mark G. Bock, Roger M. Freidinger, Ben E. Evans
  • Cholecystokinin antagonists
    Patent number: 5206238
    Abstract: Compounds of the formula: ##STR1## are disclosed which are antagonists of gastrin and cholecycstokinin (CCK) and have properties useful for treating panic disorder and for directly inducing anlagesia.
    Type: Grant
    Filed: April 15, 1992
    Date of Patent: April 27, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Mark G. Bock, Roger M. Freidinger
  • Benzodiazepine analogs
    Patent number: 5206237
    Abstract: Pharmaceutical compositions containing benzodiazepines of the formula: ##STR1## are disclosed which are useful in the treatment of panic disorder or anxiety disorder.
    Type: Grant
    Filed: May 14, 1991
    Date of Patent: April 27, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Roger M. Freidinger, Mark G. Bock, Ben E. Evans
  • Amide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists
    Patent number: 5204349
    Abstract: Compounds of the formula: ##STR1## where R.sup.1 is hydrogen or hydroxy and R.sup.2 is a substituted amino group, a substituted heterocyclic ring or a substituted alkyl. These compounds are oxytocin and vasopressin antagonists useful in the treatment of preterm labor, dysmenorrhea and for the stoppage of labor preparatory to cesarean delivery, timing of parturition, uterine hyperactivity, endometriosis, hypertension, congestive heart failure, hyponatremia and cognitive disorders. Also disclosed are pharmaceutical compositions containing these compounds, methods of their use and methods of their preparation.
    Type: Grant
    Filed: September 16, 1991
    Date of Patent: April 20, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Mark G. Bock, Ben E. Evans, Roger M. Freidinger, Kevin Gilbert, Doug W. Hobbs, James B. Hoffman, George F. Lundell, Douglas J. Pettibone
  • Fermentation analogs of Virginiamycin M.sub.1 to treat panic and anxiety disorder
    Patent number: 5189050
    Abstract: Pharmaceutical compositions containing Virginiamycin M.sub.1 having the Formula: ##STR1## and Virginiamycin M.sub.1 analogs having the Formulae I-IV: ##STR2## are disclosed which are useful in the treatment of panic disorder or anxiety disorder.
    Type: Grant
    Filed: June 3, 1991
    Date of Patent: February 23, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Roger M. Freidinger, Mark G. Bock, Yiu-Kuen T. Lam, Raymond S. Chang, Otto D. Hensens, Cheryl D. Schwartz, Deborah L. Zink
  • Triazolobenzodiazepines
    Patent number: 5185331
    Abstract: Pharmaceutical compositions containing Triazolobenzodiazepines of the formula: ##STR1## are disclosed which are useful in the treatment of panic disorder or anxiety disorder.
    Type: Grant
    Filed: May 14, 1991
    Date of Patent: February 9, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Roger M. Freidinger, Mark G. Bock, Ben E. Evans
  • 1,4-benzodiazepines with 6-membered heterocyclic rings to treat panic and anxiety disorder
    Patent number: 5177071
    Abstract: Pharmaceutical compositions containing 6-membered heterocyclic rings are disclosed which are useful in the treatment of panic disorder or anxiety disorder.
    Type: Grant
    Filed: June 17, 1991
    Date of Patent: January 5, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Roger M. Freidinger, Ben E. Evans, Mark G. Bock
  • 3-substituted-1,4-benzodiazepines as oxytocin antagonists
    Patent number: 5175159
    Abstract: Compounds of Formula I are antagonists of oxytocin and are useful in the treatment of preterm labor and dysmenorrhea, and for stoppage of labor prepatory to Caesarean delivery.
    Type: Grant
    Filed: December 28, 1990
    Date of Patent: December 29, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Mark G. Bock, Ben E. Evans, Roger M. Freidinger
  • 2-Benzazepines with 5- and 6-membered heterocyclic rings, compositions and medical methods of use thereof
    Patent number: 5166151
    Abstract: Aromatic 2-benzazepines with fused 5- or 6-membered heterocyclic rings which are antagonists of cholecystokinins and/or gastrin, and are useful in the treatment or prevention of CCK-related and/or gastrin-related disorders of the gastrointestinal, central nervous and appetite regulatory systems; compositions comprising these compounds; and methods of treatment of mammals or of increasing food intake of animals employing these compounds.
    Type: Grant
    Filed: March 11, 1991
    Date of Patent: November 24, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Roger M. Freidinger, Ben E. Evans, Mark G. Bock
  • Amino acid analogs as CCK-antagonists
    Patent number: 5089638
    Abstract: Analogs of glutamic acid and related amino acids and pharmaceutically-acceptable salts thereof which antagonize the function of cholecystokinins and gastrin disease states in animals and compositions for and methods of preventing or treating disorders of the gastrointestinal, central nervous and appetite regulatory systems of mammals, especially of humans.
    Type: Grant
    Filed: August 30, 1989
    Date of Patent: February 18, 1992
    Assignee: Merck & Co., Inc.
    Inventor: Roger M. Freidinger
  • Peptide oxytocin antagonists
    Patent number: 5026703
    Abstract: Peptide compounds of formula I are antagonists of oxytocin and are useful in the treatment of preterm labor and dysmenorrhea, and for the stoppage of labor prepatory to Caesarian delivery.
    Type: Grant
    Filed: June 11, 1990
    Date of Patent: June 25, 1991
    Assignee: Merck & Co., Inc.
    Inventors: Mark G. Bock, Roger M. Freidinger, Robert M. DiPardo
  • Methods of antagonizing CCK or gastrin with benzodiazepine analogs
    Patent number: 5004741
    Abstract: Methods of antagonizing gastrin and/or cholecystokinin (CCK) with benzodiazepine analogs are disclosed, as well as related pharmaceutical compositions, which are useful in treating disorders of the gastrointestinal tract, central nervous system, and of the appetite.
    Type: Grant
    Filed: November 9, 1988
    Date of Patent: April 2, 1991
    Assignee: Merck & Co., Inc.
    Inventors: Ben E. Evans, Mark G. Bock, Roger M. Freidinger
  • Amino acid analogs
    Patent number: 4880938
    Abstract: Analogs of glutamic acid and related amino acids and pharmaceutically-acceptable salts thereof which antagonize the function of cholecystokinins and gastrin disease states in animals and compositions for and methods of preventing or treating disorders of the gastrointestinal, central nervous and appetite regulatory systems of mammals, especially of humans.
    Type: Grant
    Filed: June 16, 1986
    Date of Patent: November 14, 1989
    Assignee: Merck & Co., Inc.
    Inventor: Roger M. Freidinger
  • 1,4-Benzodiazepines with 5- and 6-membered heterocyclic rings and their use as cholecystokinins and gastrin antagonists
    Patent number: 4847248
    Abstract: Aromatic 1,4-benzodiazepines with fused 5- or 6-membered heterocyclic rings which are antagonists of cholecystokinins and/or gastrin, and are useful in the treatment or prevention of CCK-related and/or gastrin-related disorders of the gastrointestinal, central nervous and appetite regulatory systems; compositions comprising these compounds; and methods of treatment employing these compounds.
    Type: Grant
    Filed: January 6, 1988
    Date of Patent: July 11, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Roger M. Freidinger, Ben E. Evans, Mark G. Bock
  • Benzodiazepine analogs
    Patent number: 4820834
    Abstract: Benzodiazepine analogs of the formula: ##STR1## are disclosed which are antagonists of gastrin and cholecystokinin (CCK).
    Type: Grant
    Filed: March 16, 1987
    Date of Patent: April 11, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Ben E. Evans, Roger M. Freidinger, Mark G. Bock
  • Benzodiazepine analogs and use as antogonists of gastrin and cholecystokinin
    Patent number: 4755508
    Abstract: Benzodiazepines of the formula: ##STR1## are disclosed which are antagonists of gastrin and cholecystokinin (CCK).
    Type: Grant
    Filed: February 27, 1987
    Date of Patent: July 5, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Mark G. Bock, Ben E. Evans, Roger M. Freidinger