Abstract: A well plate seal includes a matt having a plurality of spaced apart wells for engaging and sealing a plurality of exit ports in a multi-well extraction plate. Unidirectional flow control valves are disposed in each of the plurality of matt wells for enabling liquid flow out of each of the exit ports only upon application of a pressure differential across each exit port.

Abstract: A multi-well filtration or solid phase extraction apparatus is provided which generally includes a vacuum collar adapted to be interconnected between a conventional 96-well sample application plate, or separation plate, and a 96-well collection plate. The vacuum collar provides an interface chamber between these plates through which a vacuum can be applied to assist in the filtration process. The collection plate may include a vent opening providing a direct communication between the interface chamber and a vacuum assembly air intake, when the collection plate is disposed on top of the vacuum assembly in a stacked configuration, thereby eliminating any need for separate vacuum manifolds or connectors.

Abstract: A multi-well filtration or solid phase extraction apparatus is provided which generally includes a vacuum collar adapted to be interconnected between a conventional 96-well sample application plate, or separation plate, and a 96-well collection plate. The vacuum collar provides an interface chamber between these plates through which a vacuum can be applied to assist in the filtration process. The collection plate may include a vent opening providing a direct communication between the interface chamber and a vacuum assembly air intake, when the collection plate is disposed on top of the vacuum assembly in a stacked configuration, thereby eliminating any need for separate vacuum manifolds or connectors.

Abstract: A seal is provided for a well plate having a plurality of wells with each well having an opening in one end therein for influxing a fluid and another end thereof for effluxing the fluid. The seal includes a planar member having a top and bottom and a plurality of recess formed in the top and a plurality of cups formed in the bottom. A plurality of recesses are uniformly spaced apart from one another and each recess is sized for sealably engaging a corresponding well tip. The plurality of cups are uniformly spaced apart from another and sized for sealably engaging a corresponding well opening in order to enable the member to effect a sealed engagement with all of the well openings or all of the well tips.