Abstract: Novel LHRH antagonist peptides, pharmaceutical compositions thereof, and methods of use thereof, are disclosed. The LHRH antagonist comprise a peptide compound, wherein a residue of the peptide compound corresponding to the amino acid at position 6 of natural mammalian LHRH comprises a hydrophilic N-acyl moiety, a dipolar moiety, a sulfonium moiety, a receptor-modifying moiety or a small polar moiety.

Abstract: Novel LHRH antagonist peptides, pharmaceutical compositions thereof, and methods of use thereof, are disclosed. The LHRH antagonist comprise a peptide compound, wherein a residue of the peptide compound corresponding to the amino acid at position 6 of natural mammalian LHRH comprises a hydrophilic N-acyl moiety, a dipolar moiety, a sulfonium moiety, a receptor-modifying moiety or a small polar moiety.

Abstract: Novel LHRH antagonist peptides, pharmaceutical compositions thereof, and methods of use thereof, are disclosed. The LHRH antagonist comprise a peptide compound, wherein a residue of the peptide compound corresponding to the amino acid at position 6 of natural mammalian LHRH comprises a hydrophilic N-acyl moiety, a dipolar moiety, a sulfonium moiety, a receptor-modifying moiety or a small polar moiety.

Abstract: Methods of treating a subject having a disorder associated with LHRH activity are disclosed.

Abstract: The present invention is directed to a method for essentially complete oxidation of a concentrated liquor containing oxidizable organic matter. Each step of the method is performed under substantially superatmospheric pressure. Initially, the liquor is preheated to a temperature higher than about 10° C. below the boiling point of water at the substantially superatmospheric pressure. A feed formed of the concentrated liquor is then essentially completely oxidized at a temperature of at least 800° C. in the presence of a gas comprising at least sixty percent by volume of oxygen to form a suspension of a hot gas and a molten slag. The molten slag is separated from the hot gas before the slag is dissolved in water to form a brine. The separated hot gas is then cooled to a temperature below 250° C. by quenching with an aqueous liquid. Finally, the aqueous liquid is separated from the hot gas.

Abstract: Methods of treating a subject having a disorder associated with LHRH activity are disclosed.

Abstract: Novel LHRH antagonist peptides, pharmaceutical compositions thereof, and methods of use thereof, are disclosed.

Abstract: Antagonist analogs of luteinizing hormone-releasing hormone (LHRH) having N-alkylated basic amino acid residues at the 8 position, 8 and 6 positions, 8 and 5 positions, and 8, 6 and 5 positions, having high antiovulatory activity and low histamine release activity, and their use in regulating the release of gonadatropic hormones from the pituitary gland of mannals.

Abstract: Peptides which inhibit the secretion of gonadotropins by the pituitary gland and inhibit the release of steroids by the gonads. Administration of an effective amount prevents ovulation of female mammalian eggs and/or the release of steroids by the gonads, which can be used for therapeutic treatment. The peptides have the structure:X-R.sub.1 -R.sub.2 -R.sub.3 -Ser-Arg-R.sub.6 -R.sub.7 -Arg-Pro-R.sub.10 wherein X is hydrogen, Acr or Ac; R.sub.1 is .beta.-D-2NAL, dehydroPro or 4Cl-D-Phe; R.sub.2 is Cl-D-Phe, F-D-Phe, NO.sub.2 -D-Phe, Br-D-Phe or C.sup.a Me/Cl-D-Phe; R.sub.3 is D-Trp or .beta.-D-2NAL; R.sub.6 is D-Tyr, .beta.-D-2NAL or D-Arg; R.sub.7 is Leu or NML; and R.sub.10 is Gly-NH.sub.2, NHCH.sub.2 CH.sub.3 or D-Ala-NH.sub.2 ; provided however that R.sub.1 or R.sub.3 or both are .beta.-D-2NAL.

Abstract: Peptides which inhibit the secretion of gonadotropins by the pituitary gland and inhibit the release of steroids by the gonads. Administration of an effective amount prevents ovulation of female mammalian eggs and/or the release of steroids by the gonads. The peptides have the structure:X-.beta.-D-2NAL-R.sub.2 -D-Trp-Ser-Arg-R.sub.6 -R.sub.7 -Arg-Pro-R.sub.10 wherein X is hydrogen or Ac; R.sub.2 is Cl-D-Phe, F-D-Phe or C.sup..alpha. Me-Cl-D-Phe; R.sub.6 is D-Tyr, .beta.-D-2NAL or D-Arg; R.sub.7 is Leu or N.sup..alpha. Me-Leu; and R.sub.10 is Gly-NH.sub.2, NHCH.sub.2 CH.sub.3 or D-Ala-NH.sub.2.