Patents by Inventor Rohan Fernandes
Rohan Fernandes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11931465Abstract: Combination treatment with Prussian blue nanoparticles and at least one immunotherapeutic treatment. Stable, functionalized Prussian blue nanoparticles, including those with enhanced stability under alkaline conditions, and methods of cancer, neoplasm, and tumor treatment using them, including photothermal treatment and combination immunotherapeutic treatments.Type: GrantFiled: March 8, 2017Date of Patent: March 19, 2024Assignee: Children's National Medical CenterInventors: Rohan Fernandes, Raymond W. Sze, Conrad Russell Y. Cruz, Anthony D. Sandler, Catherine M. Bollard, Elizabeth E. Sweeney, Juliana Cano-Mejia, Rachel Burga, Matthieu F. Dumont
-
Publication number: 20240026294Abstract: The present disclosure generally relates target cancer cell specific immunotherapy compositions, methods of making and use thereof. Also provided in the disclosure are methods of treating a cancer in a subject in need thereof.Type: ApplicationFiled: July 10, 2023Publication date: January 25, 2024Inventors: ELIZABETH SWEENEY, ROHAN FERNANDES, MATTHEW TOVAR, PALAK SEKHRI, PREETHI BALA BALAKRISHNAN, CONRAD RUSSELL CRUZ
-
Publication number: 20230190663Abstract: Embodiments of the instant disclosure relate to novel compositions and methods for the treatment of retroviruses (e.g., HIV) and the reduction and/or eradication of latent HIV reservoirs. Compositions herein may include biofunctionalized nanocomposites comprised of a core nanoparticle formed of Prussian blue materials, a shell obtained by partially or completely encapsulating the Prussian blue core with at least one biocompatible coating, and at least one biomolecule attached to, or absorbed to, the biocompatible coating and uses thereof.Type: ApplicationFiled: September 22, 2022Publication date: June 22, 2023Inventors: ROHAN FERNANDES, PREETHI BALA BALAKRISHNAN, CARISSA STOVER, ALBERTO BOSQUE, INDRA SARABIA, ANVITHA SHRI RAMANUJAM
-
Patent number: 11672861Abstract: Biofunctionalized nanocomposites comprised of a core nanoparticle formed of Prussian blue materials, a shell obtained by partially or completely encapsulating the Prussian blue core with a biocompatible coating, and at least one biomolecule attached to, or absorbed to, the biocompatible coating and uses thereof.Type: GrantFiled: March 19, 2019Date of Patent: June 13, 2023Assignee: The George Washington UniversityInventors: Rohan Fernandes, Elizabeth Sweeney, Juliana Cano-Mejia
-
Publication number: 20220323357Abstract: Embodiments of the instant disclosure relate to novel methods and compositions for treating tumors resistant to immune checkpoint inhibitors. In certain embodiments, compositions herein can have at least one nanoparticle formed of Prussian blue materials and, optionally, one or more CD137 agonists. In other embodiments, methods of treating tumors herein can include administering an effective amount of at least photothermal therapy agent in combination with at least one CD137 agonist separately or in a combination therapy/combination composition.Type: ApplicationFiled: April 5, 2022Publication date: October 13, 2022Inventors: Rohan Fernandes, Elizabeth Sweeney, Preethi Bala Balakrishnan, Jacob Medina
-
Publication number: 20200163899Abstract: Combination treatment with Prussian blue nanoparticles and at least one immunotherapeutic treatment. Stable, functionalized Prussian blue nanoparticles, including those with enhanced stability under alkaline conditions, and methods of cancer, neoplasm, and tumor treatment using them, including photothermal treatment and combination immunotherapeutic treatments.Type: ApplicationFiled: March 8, 2017Publication date: May 28, 2020Applicant: Children's National Medical CenterInventors: Rohan FERNANDES, Raymond W. SZE, Conrad Russell Y. CRUZ, Anthony D. SANDLER, Catherine M. BOLLARD, Elizabeth E. SWEENEY, Juliana CANO-MEJIA, Rachel BURGA, Mathieu F. DUMONT
-
Publication number: 20200114005Abstract: Biofunctionalized nanocomposites comprised of a core nanoparticle formed of Prussian blue materials, a shell obtained by partially or completely encapsulating the Prussian blue core with a biocompatible coating, and at least one biomolecule attached to, or absorbed to, the biocompatible coating and uses thereof.Type: ApplicationFiled: March 19, 2019Publication date: April 16, 2020Inventors: Rohan Fernandes, Elizabeth Sweeny, Juliana Cano-Mejia
-
Publication number: 20190282307Abstract: System and method for tracking and control in medical procedures. The system including a device that deploys fluorescent material on at least one of an organ under surgery and a surgical tool, a visual light source, a fluorescent light source corresponding to an excitation wavelength of the fluorescent material, an image acquisition and control element that controls the visual light source and the fluorescent light source, and captures and digitizes at least one of resulting visual images and fluorescent images, and an image-based, tracking module that applies image processing to the visual and fluorescent images, the image processing detecting fluorescent markers on at least one of the organ and the surgical tool.Type: ApplicationFiled: March 25, 2019Publication date: September 19, 2019Applicant: Children's National Medical CenterInventors: Mahdi AZIZIAN, Peter Kim, Axel Krieger, Simon Leonard, Azad Shademan, Ryan Decker, Justin Opfermann, Matthieu Dumont, Nick Uebele, Lydia Carroll, Ryan Walter, Rohan Fernandes
-
Patent number: 9987378Abstract: The invention describes a coordination polymer construct for multimodal imaging and therapy. The construct consists of a core particle made of a novel coordination polymer. The core is coated with a biocompatible coating that stabilizes the particles in a physiological environment. The biocompatible coating can contain attached targeting agents, imaging agents and therapeutic agents or combinations one or more of the targeting, imaging and therapeutic agents. When administered to a subject or a subject-derived specimen, the resulting coordination polymer core-shell construct enables multimodal imaging and therapy, which improves the diagnostic and treatment outcomes of the conditions or diseases where it is administered. The invention describes the novel material, base for the construct, methods for the preparation of the said construct and its use as a multimodal imaging and therapy agent.Type: GrantFiled: December 23, 2016Date of Patent: June 5, 2018Assignee: Children's National Medical CenterInventors: Rohan Fernandes, Matthieu F. Dumont, Raymond W. Sze, Laurie S. Conklin, Hilary A. Hoffman, Jyoti K. Jaiswal
-
Publication number: 20170173187Abstract: The invention describes a coordination polymer construct for multimodal imaging and therapy. The construct consists of a core particle made of a novel coordination polymer. The core is coated with a biocompatible coating that stabilizes the particles in a physiological environment. The biocompatible coating can contain attached targeting agents, imaging agents and therapeutic agents or combinations one or more of the targeting, imaging and therapeutic agents. When administered to a subject or a subject-derived specimen, the resulting coordination polymer core-shell construct enables multimodal imaging and therapy, which improves the diagnostic and treatment outcomes of the conditions or diseases where it is administered. The invention describes the novel material, base for the construct, methods for the preparation of the said construct and its use as a multimodal imaging and therapy agent.Type: ApplicationFiled: December 23, 2016Publication date: June 22, 2017Applicant: Children's National Medical CenterInventors: Rohan FERNANDES, Matthieu F. DUMONT, Raymond W. SZE, Laurie CONKLIN, Hilary HOFFMAN, Jyoti JAISWAL
-
Patent number: 9561183Abstract: The invention describes a coordination polymer construct for multimodal imaging and therapy. The construct consists of a core particle made of a novel coordination polymer. The core is coated with a biocompatible coating that stabilizes the particles in a physiological environment. The biocompatible coating can contain attached targeting agents, imaging agents and therapeutic agents or combinations one or more of the targeting, imaging and therapeutic agents. When administered to a subject or a subject-derived specimen, the resulting coordination polymer core-shell construct enables multimodal imaging and therapy, which improves the diagnostic and treatment outcomes of the conditions or diseases where it is administered. The invention describes the novel material, base for the construct, methods for the preparation of the said construct and its use as a multimodal imaging and therapy agent.Type: GrantFiled: March 14, 2014Date of Patent: February 7, 2017Assignee: Children's National Medical CenterInventors: Rohan Fernandes, Matthieu F. Dumont, Raymond W. Sze, Laurie S. Conklin, Hilary A. Hoffman, Jyoti K. Jaiswal
-
Publication number: 20140271487Abstract: The invention describes a coordination polymer construct for multimodal imaging and therapy. The construct consists of a core particle made of a novel coordination polymer. The core is coated with a biocompatible coating that stabilizes the particles in a physiological environment. The biocompatible coating can contain attached targeting agents, imaging agents and therapeutic agents or combinations one or more of the targeting, imaging and therapeutic agents. When administered to a subject or a subject-derived specimen, the resulting coordination polymer core-shell construct enables multimodal imaging and therapy, which improves the diagnostic and treatment outcomes of the conditions or diseases where it is administered. The invention describes the novel material, base for the construct, methods for the preparation of the said construct and its use as a multimodal imaging and therapy agent.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicant: Children's National Medical CenterInventors: Rohan FERNANDES, Matthieu F. DUMONT, Raymond W. SZE, Laurie CONKLIN, Hilary HOFFMAN, Jyoti JAISWAL
-
Patent number: 7883615Abstract: A method is provided for electrochemically depositing a polysaccharide mass having a selected physical state. According to an embodiment, an electrically conductive support of a substrate is contacted with an aqueous solution including a selectively insolubilizable polysaccharide, and the selectively insolubilizable polysaccharide is electrochemically deposited on the electrically conductive support while controlling deposition conditions to form the polysaccharide mass having the selected physical state, such as that of a hydrogel. Deposition may be performed in a spatially and/or temporally controlled manner.Type: GrantFiled: February 11, 2004Date of Patent: February 8, 2011Assignees: University of Maryland, College Park, University of Maryland, Baltimore CountyInventors: Gregory F. Payne, Li-Qun Wu, Reza Ghodssi, William E. Bentley, Gary W. Rubloff, Hyunmin Yi, Rohan Fernandes, Tianhong Chen, David A. Small
-
Patent number: 7820227Abstract: A method for biolithographical deposition of molecules is provided. According to an embodiment of the method, a reactive layer (e.g., a polysaccharide mass) having a surface region coated with a biologically compatible resist is provided. A portion of the biologically compatible resist is selectively removed to expose an exposed portion of the reactive layer. Molecules, such as biomolecules and/or cellular species, are then conjugated to the exposed portion of the reactive layer. Also provided are materials and devices related to the method.Type: GrantFiled: February 20, 2004Date of Patent: October 26, 2010Assignees: University of Maryland, College Park, University of Maryland, Baltimore CountyInventors: Gregory F. Payne, Gary W. Rubloff, Hyunmin Yi, Rohan Fernandes, Li-Qun Wu, Reza Ghodssi, William E. Bentley
-
Publication number: 20070275246Abstract: A method for biolithographical deposition of molecules is provided. According to an embodiment of the method, a reactive layer (e.g., a polysaccharide mass) having a surface region coated with a biologically compatible resist is provided. A portion of the biologically compatible resist is selectively removed to expose an exposed portion of the reactive layer. Molecules, such as biomolecules and/or cellular species, are then conjugated to the exposed portion of the reactive layer. Also provided are materials and devices related to the method.Type: ApplicationFiled: February 20, 2004Publication date: November 29, 2007Applicant: University of Maryland, College ParkInventors: Gregory Payne, Gary Rubloff, Hyunmin Yi, Rohan Fernandes, Li-Qun Wu, Reza Ghodssi, William Bentley
-
Publication number: 20070068824Abstract: A method is provided for electrochemically depositing a polysaccharide mass having a selected physical state. According to an embodiment, an electrically conductive support of a substrate is contacted with an aqueous solution including a selectively insolubilizable polysaccharide, and the selectively insolubilizable polysaccharide is electrochemically deposited on the electrically conductive support while controlling deposition conditions to form the polysaccharide mass having the selected physical state, such as that of a hydrogel. Deposition may be performed in a spatially and/or temporally controlled manner.Type: ApplicationFiled: February 11, 2004Publication date: March 29, 2007Inventors: Gregory Payne, Li-Qun Wu, Reza Ghodssi, William Bentley, Gary Rubloff, Hyunmin Yi, Rohan Fernandes, Tianhong Chen, David Small